Effect of mirtazapine treatment on serotonin transporter in blood peripheral lymphocytes of major depression patients

International Immunopharmacology

Volumn 5, Issue 6, 2005, Pages 1069-1076

  Peña, Solisbella ^b   Baccichet, Edith ^b   Urbina, Mary ^a   Carreira, Isabel ^b   Lima, Lucimey ^a  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b Hosp Ctro de Salud Mental del Este   (Venezuela)

Author keywords

Lymphocytes; Major depression; Mirtazapine; Noradrenaline; Serotonin; Serotonin transporter

Indexed keywords

ANTIDEPRESSANT AGENT; CITALOPRAM; FLUOXETINE; MIRTAZAPINE; PAROXETINE; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRITIUM;

ADULT; ARTICLE; BECK DEPRESSION INVENTORY; BINDING AFFINITY; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITY GRADIENT; DISEASE CLASSIFICATION; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; FEMALE; HAMILTON SCALE; HUMAN; HUMAN CELL; ISOTOPE LABELING; LIGAND BINDING; MAJOR DEPRESSION; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; REDUCTION; SCORING SYSTEM;

EID: 17044410491     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2005.02.005     Document Type: Article

References (46)

1. L. Lima Avances en el conocimiento del transportador de serotonina. Relevancia en Psiquiatría Neuropsicofarmacología 4 2002 23 28
2. D. Marazziti, A. Rossi, I. Masala, A. Rotondo, L. Palego, and M. Mazzoni Regulation of the platelet serotonin transporter by protein kinase C in the young and elderly Biol Psychiatry 45 1999 443 447
3. 3H] paroxetine binding to human peripheral lymphocyte membranes of patients with major depression before and after treatment with fluoxetine Int J Immunopharmacol 21 1999 631 646
4. B. Bottalico, I. Larsson, J. Brodszki, E. Hernández-Andrade, B. Casslen, and K. Marsal Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies Placenta 25 2004 518 529
5. R.T. Malison, L.H. Price, R. Berman, C.H. van Dyck, G.H. Pelton, and L. Carpenter Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3-beta-(4-iodophenyl)tropane and single photon emission computed tomography Biol Psychiatry 44 1998 1090 1098
6. M.J. Owens, and C.B. Nemerdf The serotonin transporter and depression Depress Anxiety 8 Suppl 1 1998 5 12
7. N. Sakai Functional regulation of serotonin transporter, a molecule involved in the pathogenesis of anxiety disorder Nihon Shinkei Seishen Yakurigaku Zasshi 24 2002 101 110
8. R.A. Vaughan Phosphorylation and regulation of psychostimulant-sensitive neurotransmitter transporters J Pharmacol Exp Ther 310 2004 1 7
9. C.E. Glatt, and V.I. Reus Pharmacogenetics of monoamine transporters Pharmacogenetics 4 2003 583 596
10. K. Glatz, R. Mossner, A. Heils, and K.P. Lesch Glucocorticoid-regulated serotonin transporter (5-HTT) expression is modulated by the 5-HTT gene-promotor-linked polymorphic region J Neurochem 86 2003 1072 1078
11. P.Y. Lin, and G. Tsai Association Between Serotonin Transporter Gene Promoter Polymorphism and Suicide: Results of a Meta-analysis Biol Psychiatry 55 2004 1023 1030
12. M. Nellissery, R.S. Feinn, J. Covault, J. Gelernter, R.F. Anton, and H. Pettinati Alleles of a functional serotonin transporter promoter polymorphism are associated with major depression in alcoholics Alcohol, Clin Exp Res 27 2003 1402 1408
13. A. Serretti, and P. Artioli From biology to pharmacogenetics: a review of the literature on antidepressant treatment and suggestions of possible candidate genes Psychopharmacology 174 2004 490 503
14. M. Willeit, N. Praschak-Rieder, A. Neumeister, P. Zill, F. Leisch, and J. Stastny A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder Mol Psychiatry 8 2003 942 946
15. A. Caspi, K. Sugden, T.E. Moffitt, A. Taylor, I.W. Craig, and H. Harrington Influence of life stress on depression: moderation by polymorphism in the 5-HTT gene Science 301 2003 386 389
16. E. Hernández, S. Lastra, M. Urbina, I. Carreira, and L. Lima Serotonin transporter and concentration in blood peripheral lymphocytes of patients with generalized anxiety disorder Int J Immunopharmacol 2 2002 893 900
17. S. Lastra, E. Hernández, M. Urbina, I. Carreira, and L. Lima Comorbilidad del trastorno de ansiedad generalizada con trastornos de personalidad. Niveles de serotonina y de su transportador en linfocitos Neurofarmacología 5 2003 19 27
18. L. Lima, S. Mata, and M. Urbina ARN mensajero y polimorfismo del transportador de serotonina en linfocitos de pacientes con depresión mayor Rev Soc Vlna Psiq 102 2004 33 40
19. Lima L, Mata S, Urbina M. Allelic isophorms and decrease of serotonin transporter mRNA in lymphocytes of major depression patients. NeuroImmunoModulation in press.
20. P.L. Delgado, and F.A. Moreno Role of norepinephrine in depression J Clin Psychiatry 61 Suppl 1 2000 5 12
21. J.M. Gorman Mirtazapine: clinical overview J Clin Psychiatry 60 Suppl 19 1999 9 13
22. A. Dekeyne, and M.J. Millan Discriminative stimulus properties of antidepressant agents: a review Behav Pharmacol 14 2003 391 407
23. J.M. Kent SNaRIs, NaSSAs, and NaRIs: new agents for the treatment of depression Lancet 355 2000 911 918
24. R.L. Barkin, P.N. Chor, B.G. Braun, and W.A. Schwer A trilogy case review highlighting the clinical and pharmacologic applications of mirtazapine in reducing polypharmacy for anxiety, agitation, insomnia, depression, and sexual dysfunction Prim Care Companion J Clin Psychiat 1 1999 142 145
25. B. Eisensamer, G. Rammes, G. Gimpl, M. Shapa, U. Ferrari, and G. Hapfelmeier Antidepressants are funcional antagonists at the serotonin type 3 (5-HT3) receptor Mol Psychiatry 8 2003 994 1007
26. K. Nakayama, T. Sakurai, and H. Katsu Mirtazapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation Brain Res Bull 63 2004 237 241
27. C.C. Crone, and G.M. Gabriel Treatment of anxiety and depression in transplant patients: pharmacokinetic considerations Clin Pharmacokinet 43 2004 361 394
28. P. Pacher, and V. Kecskemeti Trends in the development of new antidepressants. Is there a light at the end of the tunnel? Curr Med Chem 11 2004 925 943
29. American Psychiatric Association DSM-iV: Diagnostic and Statistical Manual for Mental Disorders 3rd ed. 1994 APA Washington, DC
30. M.A. Hamilton A rating scale of depression J Neurol Neurosurg Psychiatry 23 1960 56 62
31. A.T. Beck, C.H. Ward, and M. Mendelses An inventory for measuring depression Arch Gen Psychiatry 4 1961 561 567
32. 3H]serotonin: modulation by light J Neurochem 62 1994 528 535
33. 1A receptors in the hippocampus and the raphe area of rats treated with clonazepam Prog Neuro-Psychopharmacol Biol Psychiatry 17 1993 663 677
34. H. Moltusky Intuitive Statistics 1995 Oxford University Press New York
35. GraphPad, Prisma, Version 4th; 2003.
36. R.M. Hirschfeld Efficacy of SSRIs and newer antidepressants in severe depression: comparison with TCAs J Clin Psychiatry 60 1999 326 335
37. A. Heiske, J. Jesberg, J.C. Krieg, and H. Vedder Differential effects of antidepressants on glucocorticoid receptors in human primary blood cells and human monocyte U-937 cells Neuropsychopharmacology 28 2003 807 817
38. J. Gordon, and N.M. Barnes Lymphocytes transport serotonin and dopamine: agony or ecstasy? Trends Immunol 24 2003 438 443
39. C. Schule, T. Baghai, M. Bidlingmaier, C. Strasburger, and G. Laakmann Endocrinological effects of mirtazapine in healthy volunteers Prog Neuro-psychopharmacol Biol Psychiatry 26 2002 1253 1261
40. C. Schule, T. Baghai, and G. Laakmann Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects Neuroendocrinology 79 2004 54 62
41. E. Palazidou, A. Papadopoulos, A. Sitsen, S. Stahl, and S. Checkley An alpha 2 adrenoceptor antagonist, org 3770, enhances nocturnal melatonin secretion in man Psychopharmacology 97 1989 115 117
42. C. Schule, T. Baghai, C. Rackwiitz, and G. Laakmann Influence of mirtazapine on urinary free cortisol excretion in depressed patients 79 2003 54 62
43. L.I. Tammela, A. Rissanen, J.T. Kuikka, L.J. Karhunen, K.A. Bergstrom, and E. Repo-Tiihoner Treatment improves serotonin transporter binding and reduces binge eating Psychopharmacology 170 2003 89 93
44. R. Mossner, S. Daniel, A. Schmitt, D. Albert, and K.P. Lesch Modulation of serotonin transporter function by interleukin-4 Life Sci 68 2001 873 880
45. A. Palotás, L.G. Puskás, K. Kitajka, M. Palotás, J. Molnár, and M. Pákáski Altered response to mirtazapine on gene expression profile of lymphocytes from Alzheimer's patients Eur J Pharmacol 497 2004 247 254
46. 1A receptors on activated human T cells: regulation of cAMP levels and T cell proliferation by 5HT J Immunol 16 1993 561 567