Treatment improves serotonin transporter binding and reduces binge eating

Psychopharmacology

Volumn 170, Issue 1, 2003, Pages 89-93

  Tammela, Liisa I ^a   Rissanen, Aila ^b   Kuikka, Jyrki T ^a   Karhunen, Leila J ^a   Bergström, Kim A ^a   Repo Tiihonen, Eila ^c   Naukkarinen, Hannu ^b   Vanninen, Esko ^a   Tiihonen, Jari ^b   Uusitupa, Matti ^a  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Eating disorder; Serotonin transporters; SPECT; Treatment

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; FLUOXETINE; SEROTONIN; SEROTONIN TRANSPORTER; TRACER;

ADULT; ARTICLE; BINGE EATING DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN BINDING; PSYCHOTHERAPY; SEROTONIN UPTAKE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ADULT; BULIMIA; CARRIER PROTEINS; FEMALE; FLUOXETINE; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MESENCEPHALON; NERVE TISSUE PROTEINS; PROTEIN BINDING; PSYCHOTHERAPY; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 10744219622     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-003-1519-6     Document Type: Article

References (15)

1. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association, Washington D.C.
2. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:53-63
3. Fairburn CG, Cooper Z (1993) The Eating Disorder Examination. In: Fairburn CG, Wilson GT (eds) Binge eating: nature, assessment, and treatment. Guilford, New York, pp 317-332
4. Gormally J, Black S, Daston S, Rardin D (1982) The assessment of binge eating severity among obese persons. Addict Behav 7:47-55
5. Henderson M, Freeman CP (1987) A self-rating scale for bulimia. The BITE. Br J Psychiatry 150:18-24
6. Kaye WH, Greeno CG, Moss H, Fernstrom J, Fernstrom M, Lilenfeld LR, Weltzin TE, Mann JJ (1998) Alterations in serotonin activity and psychiatric symptoms after recovery from bulimia nervosa. Arch Gen Psychiatry 55:927-935
7. Kuikka JT, Tammela L, Bergstrom KA, Karhunen L, Uusitupa M, Tiihonen J (2001a) Effects of ageing on serotonin transporters in healthy females. Eur J Nucl Med 28:911-913
8. Kuikka JT, Tammela L, Karhunen L, Rissanen A, Bergstrom KA, Naukkarinen H, Vanninen E, Karhu J, Lappalainen R, RepoTiihonen E, Tiihonen J, Uusitupa M (2001b) Reduced serotonin transporter binding in binge eating women. Psychopharmacology 155:310-314
9. Leibowitz SF, Alexander JT (1998) Hypothalamic serotonin in control of eating behavior, meal size, and body weight. Biol Psychiatry 44:851-864
10. 123I-beta-CIT SPECT: binding kinetics and effects of normal aging. J Nucl Med 41:36-44
11. Spitzer RL, Yanovski S, Wadden T, Wing R, Marcus MD, Stunkard A, Devlin M, Mitchell J, Hasin D, Horne RL (1993) Binge eating disorder: its further validation in a multisite study. Int J Eat Disord 13:137-153
12. Steiger H, Young SN, Kin NM, Koerner N, Israel M, Lageix P, Paris J (2001) Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa. Psychol Med 31:85-95
13. Tauscher J, Pirker W, de Zwaan M, Asenbaum S, Brucke T, Kasper S (1999) In vivo visualization of serotonin transporters in the human brain during fluoxetine treatment. Eur Neuropsychopharmacol 9:177-179
14. 123I] beta-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa. Biol Psychiatry 49:326-332
15. 123I] beta-CIT SPECT. Neurobiol Aging 21:497-501