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Volumn 44, Issue 11, 2005, Pages 1654-1658

Iron-catalyzed aryl-aryl cross-couplings with magnesium-derived copper reagents

Author keywords

Copper; Cross coupling; Homogeneous catalysis; Iron; Magnesium

Indexed keywords

CATALYSIS; CATALYSTS; COPPER; DERIVATIVES; ESTERS; MAGNESIUM PRINTING PLATES;

EID: 17044409192     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200462013     Document Type: Article
Times cited : (134)

References (75)
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    • note
    • In the absence of the iron catalyst, no reaction was observed for 2-chlorobenzophenone.
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    • note
    • We submitted the substituted iodoesters 3g-i to Pd-and Ni-catalyzed cross-coupling and found that in the case of Pd catalysis, 4-iodoester 3i reacts significantly faster than 3g and 3h, whereas under Ni catalysis, the 3-iodoester 3h is the fastest. These results indicate that the mechanism of Ni-, Pd- and Fe-catalyzed cross-coupling reactions is significantly different, as electronic and steric effects of the substituents affect them differently (see Supporting Information for details).
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    • note
    • Interestingly, copper reagents made from aryl lithium species can also be used. The reaction proceeds at a similar rate (somewhat faster). The occurrence of an I-Cu exchange reaction is minimized with this type of copper species (ArCu(CN)Li).
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    • note
    • A patent application for this and related crossing-coupling reactions has been filed.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.