Factor Xa - Protease activated receptor interface: A paradigm for combination pharmacotherapy [2]

Journal of Thrombosis and Thrombolysis

Volumn 18, Issue 2, 2004, Pages 153-155

  Becker, Richard C ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GROWTH FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; PADGEM PROTEIN; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN RECEPTOR ACTIVATING PEPTIDE; THROMBOCYTE ACTIVATING FACTOR; THROMBOPLASTIN; TRYPSIN; VASCULAR CELL ADHESION MOLECULE 1; VON WILLEBRAND FACTOR;

AMINO TERMINAL SEQUENCE; ATHEROGENESIS; CELL ACTIVATION; CYTOKINE RELEASE; ENDOTHELIUM CELL; ENZYME ANALYSIS; ENZYME LOCALIZATION; HISTAMINE RELEASE; HUMAN; INFLAMMATION; LETTER; LEUKOCYTE ACTIVATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; THROMBOGENESIS;

DRUG DELIVERY SYSTEMS; DRUG THERAPY, COMBINATION; FACTOR XA; HUMANS; RECEPTORS, PROTEINASE-ACTIVATED; THROMBOSIS;

EID: 16844386955     PISSN: 09295305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11239-004-0212-x     Document Type: Letter

References (19)

1. Hoffman M, Monroe DM III. A cell-based model of hemostasis. Thromb Haemost 2001;85:958-965.
2. Mann KG, Krishnaswamy S, Lawson JH. Surface-dependent hemostasis. Semin Hematol 1992;29:213-226.
3. Grand RJ, Turnell AS, Grabham PW. Cellular consequences of thrombin-receptor activation. Biochem J 1996;313:353-368.
4. Coughlin SR. How the protease thrombin talks to cells. Proc Natl Acad Sci USA 1999;96:11023-11027.
5. Dery O, Corvera CU, Steinhoff M, Bunnett NW. Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases. Am J Physiol 1998;274:C1429-C1452.
6. Nelken NA, Soifer SJ, O'Keefe J, Vu TK, Charo IF, Coughlin SR. Thrombin receptor expression in normal and atherosclerotic human arteries. J Clin Invest 1992;90:1614-1621.
7. Kaplanski G, Marin V, Fabrigoule M, et al. Thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intercellular adhesion molecule-1 (ICAM-1; CD54) and vascular cell adhesion molecule-1 (VCAM-1; CD106). Blood 1998;92:1259-1267.
8. Lidington EA, Haskard DO, Mason JC. Induction of decay-accelerating factor by thrombin through a protease-activated receptor 1 and protein kinase C-dependent pathway protects vascular endothelial cells from complement-mediated injury. Blood 2000;96:2784-2792.
9. Libby P, Sukhova G, Lee RT, Liao JK. Molecular biology of atherosclerosis. Int J Cardiol 1997;62(Suppl 2):S23-S29.
10. Morris R, Winyard PG, Blake DR, Morris CJ. Thrombin in inflammation and healing: Relevance to rheumatoid arthritis. Ann Rheum Dis 1994;53:72-79.
11. Schini-Kerth VB, Bassus S, Fisslthaler B, Kirchmaier CM, Busse R. Aggregating human platelets stimulate the expression of thrombin receptors in cultured vascular smooth muscle cells via the release of transforming growth factor-beta1 and platelet-derived growth factorAB. Circulation 1997;96:3888-3896.
12. Chambers RC, Leoni P, Blanc-Brude OP, Wembridge DE, Laurent GJ. Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1. J Biol Chem 2000;275:35584-35591.
13. Lova P, Campus F, Lombardi R, et al. Contribution of protease-activated receptors 1 and 4 and glycoprotein 1b-1X-V in the Gi-independent activation of platelet Rap1B by thrombin. J Biol Chem 2004;279:25299-25306.
14. Dubois C, Steiner B, Meyer Reigner SC. Contribution of PAR-1, PAR-4 and GPIbalpha in intracellular signaling leading to the cleavage of the beta3 cytoplasmic domain during thrombin-induced platelet aggregation. Thromb Haemost 2004;91:733-742.
15. Lindner JR, Kahn ML, Coughlin SR, et al. Delayed onset of inflammation in protease-activated receptor-2-deficient mice. J Immunol 2000;165:6504-6510.
16. Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci USA 2000;97:5255-5260.
17. Langer F, Morys-Wortmann C, Kusters B, Storck J. Endothelial protease-activated receptor-2 induces tissue factor expression and von Willebrand factor release. Br J Haematol 1999;105:542-550.
18. Bono F, Schaeffer P, Herault JP, Michaux C, Nestor AL, Guillemot JC, Herbert JM. Factor Xa activates endothelial cells by a receptor cascade between EPR-1 and PAR-2. Arterioscler Thromb Vasc Biol 2000;20:E107-E112.
19. Cunningham MA, Romas P, Hutchinson P, Holdsworth SR, Tipping PG. Tissue factor and factor VIIa receptor/ligand interactions induce proinflammatory effects in macrophages. Blood 1999;94:3413-3420.