Molecular biology of atherosclerosis

International Journal of Cardiology

Volumn 62, Issue SUPPL. 2, 1997, Pages

  Libby, Peter ^a   Sukhova, Galina ^b   Lee, Richard T ^b   Liao, James K ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Arteriosclerosis; Atherogenesis; Leukocytes

Indexed keywords

CATHEPSIN; COLLAGEN; ELASTIN; GROWTH FACTOR; MESSENGER RNA; NITRIC OXIDE; PLATELET DERIVED GROWTH FACTOR; VASCULAR CELL ADHESION MOLECULE 1;

ATHEROGENESIS; ATHEROMA; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; COLLAGEN SYNTHESIS; CONFERENCE PAPER; CORONARY ARTERY ATHEROSCLEROSIS; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; PRIORITY JOURNAL; VASCULAR SMOOTH MUSCLE;

EID: 0031593119     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5273(97)00238-6     Document Type: Conference Paper

References (59)

1. Osler W, McCrea T, editors. Diseases of the arteries. Philadelphia: Lea and Febiger, 1908.
2. Bevilacqua M.P. Endothelial-leukocyte adhesion molecules. Ann Rev Immunol. 11:1993;767-804.
3. Osborn L., Hession C., Tizard R., Vassallo C., Luhowskyj S., Chi-Rosso G., Lobb R. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell. 59:1989;1203-1211.
4. Elices M.J., Osborn L., Takada Y., Crouse C., Luhowskyj S., Hemler M.E., Lobb R. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell. 60:1990;577-584.
5. Cybulsky M.I., Gimbrone M.A. Jr. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science. 251:1991;788-791.
6. Li H., Cybulsky M.I., Gimbrone M.A. Jr., Libby P. An atherogenic diet rapidly induces VCAM-1, a cytokine regulatable mononuclear leukocyte adhesion molecule, in rabbit endothelium. Arterioscler Thromb. 13:1993;197-204.
7. Kume N., Cybulsky M.I., Gimbrone M.A. Jr. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J Clin Invest. 90:1992;1138-1144.
8. Pober J.S., Gimbrone M.A. Jr., Lapierre L.A.et al. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J Immunol. 137:1986;1893-1896.
9. Nagel T., Resnick N., Atkinson W.J., Dewey C. Jr., Gimbrone M.A. Jr. Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells. J Clin Invest. 94:1994;885-891.
10. Kubes P., Suzuki M., Granger D.N. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA. 88:1991;4651-4655.
11. Bath P.M., Hassall D.G., Gladwin A.M., Palmer R.M., Martin J.F. Nitric oxide and prostacyclin. Divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro. Arterioscler Thromb. 11:1991;254-260.
12. Lefer A.M., Ma X.L. Decreased basal nitric oxide release in hypercholesterolemia increases neutrophil adherence to rabbit coronary artery endothelium. Arterioscler Thromb. 13:1993;771-776.
13. Tsao P.S., McEvoy L.M., Drexler H., Butcher E.C., Cooke J.P. Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. Circulation. 89:1994;2176-2182.
14. DeCaterina R., Libby P., Peng H.B.et al. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest. 96:1995;60-68.
15. Khan B.V., Harrison D.G., Olbrych M.T., Alexander R.W., Medford R.M. Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Proc Natl Acad Sci USA. 93:1996;9114-9119.
16. Collins T. Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion. Lab Invest. 68:1993;499-508.
17. Collins T., Read M.A., Neish A.S., Whitley M.Z., Thanos D., Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J. 9:1995;899-909.
18. Peng H.B., Libby P., Liao J.K. Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B. J Biol Chem. 270:1995;14214-14219.
19. Auphan N., DiDonato J.A., Rosette C., Helmberg A., Karin M. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science. 270:1995;286-290.
20. Scheinman R.I., Cogswell P.C., Lofquist A.K., Baldwin A. Jr. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science. 270:1995;283-286.
21. Kodama T., Freeman M., Rohrer L., Zabrecky J., Matsudaira P., Krieger M. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature. 343:1990;531-535.
22. Endemann G., Stanton L.W., Madden K.S., Bryant C.M., White R.T., Protter A.A. CD36 is a receptor for oxidized low density lipoprotein. J Biol Chem. 268:1993;11811-11816.
23. Ramprasad M.P., Fischer W., Witztum J.L., Sambrano G.R., Quehenberger O., Steinberg D. The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosialin, the mouse homologue of human CD68. Proc Natl Acad Sci USA. 92:1995;9580-9584.
24. Ross R., Glomset J.A. The pathogenesis of atherosclerosis I. New Engl J Med. 295:1976;369-377.
25. Ross R., Glomset J.A. The pathogenesis of atherosclerosis II. New Engl J Med. 295:1976;420-425.
26. Joris T., Nunnari J.J., Krolikowski F.J., Majno G. Studies on the pathogenesis of atherosclerosis. I. Adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats. Am J Pathol. 113:1983;341-358.
27. Faggiotto A., Ross R., Harker L. Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation. Arteriosclerosis. 4:1984;323-340.
28. Barrett T.B., Gajdusek C.M., Schwartz S.M., McDougall J.K., Benditt E.P. Expression of the sis gene by endothelial cells in culture and in vivo. Proc Natl Acad Sci USA. 81:1984;6772-6774.
29. Collins T., Ginsburg D., Boss J.M., Orkin S.H., Pober J.S. Cultured human endothelial cells express platelet-derived growth factor chain 2: cDNA cloning and structural analysis. Nature. 316:1985;748-750.
30. Collins T., Pober J.S., Gimbrone M.A. Jr.et al. Cultured human endothelial cells express platelet-derived growth factor A chain. Am J Pathol. 127:1987;7-12.
31. Libby P., Warner S.J.C., Salomon R.N., Birinyi L.K. Production of platelet-derived growth factor-like mitogen by smooth-muscle cells from human atheromata. New Engl J Med. 318:1988;1493-1498.
32. Ross R. The pathogenesis of atherosclerosis - an update. New Engl J Med. 314:1986;488-500.
33. Libby P, Ross R. Cytokines and growth regulatory molecules. Philadelphia: Lippincott-Raven, 1996.
34. Raines E.W., Dower S.K., Ross R. Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA. Science. 243:1989;393-396.
35. Gay C.G., Winkles J.A. Interleukin 1 regulates heparin-binding growth factor 2 gene expression in vascular smooth muscle cells. Proc Natl Acad Sci USA. 88:1991;296-300.
36. Gibbons G.H., Pratt R.E., Dzau V.J. Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II. J Clin Invest. 90:1992;456-461.
37. Amento E.P., Ehsani N., Palmer H., Libby P. Cytokines positively and negatively regulate intersitial collagen gene expression in human vascular smooth muscle cells. Arteriosclerosis. 11:1991;1223-1230.
38. Virchow R. Cellular pathology. London: Churchill, 1858.
39. Giachelli C.M., Liaw L., Murry C.E., Schwartz S.M., Almeida M. Osteopontin expression in cardiovascular diseases. Ann New York Acad Sci. 760:1995;109-126.
40. Watson K.E., Bostrom K., Ravindranath R., Lam T., Norton B., Demer L.L. TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. J Clin Invest. 93:1994;2106-2113.
41. Watson K.E., Demer L.L. The atherosclerosis-calcification link? Curr Opin Lipidol. 7:1996;101-104.
42. Fuster V., Stein B., Ambrose J.A., Badimon L., Badimon J.J., Chesebro J.H. Atherosclerotic plaque rupture and thrombosis: evolving concepts. Circulation. 82(Suppl II):1990;II47-59.
43. Falk E., Shah P., Fuster V. Coronary plaque disruption. Circulation. 92:1995;657-671.
44. Wilcox J.N., Smith K.M., Schwartz S.M., Gordon D. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Natl Acad Sci USA. 86:1989;2839-2843.
45. Drake T.A., Morrissey J.H., Edgington T.S. Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis. Am J Pathol. 134:1989;1087-1097.
46. Davies M.J., Thomas A.C. Plaque fissuring - the cause of acute myocardial infarction, sudden ischemic death, and crescendo angina. Br Heart J. 53:1985;363-373.
47. Falk E. Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi. Br Heart J. 50:1983;127-134.
48. Libby P. The molecular bases of the acute coronary syndromes. Circulation. 91:1995;2844-2850.
49. Liau G., Chan L.M. Regulation of extracellular matrix RNA levels in cultured smooth muscle cells. Relationship to cellular quiescence. J Biol Chem. 264:1989;10315-10320.
50. van der Wal A.C., Becker A.E., van der Loos C.M., Das P.K. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation. 89:1994;36-44.
51. Rekhter M., Zhang K., Narayanan A., Phan S., Schork M., Gordon D. Type I collagen gene expression in human atherosclerosis. Localization to specific plaque regions. Am J Pathol. 143:1993;1634-1648.
52. Woessner J.J. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 5:1991;2145-2154.
53. Galis Z., Muszynski M., Sukhova G.et al. Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion. Circ Res. 75:1994;181-189.
54. Saren P., Welgus H.G., Kovanen P.T. TNF-alpha and IL-1 beta selectively induce expression of 92-kDa gelatinase by human macrophages. J Immunol. 157:1996;4159-4165.
55. Sukhova G., Simon D., Chapman H., Libby P. Cytokines regulate the expression by vascular smooth muscle cells of cathepsin S, an elastase found in human atheroma. J Invest Med. 43:1995;311A.
56. Geng Y.-J., Libby P. Evidence for apoptosis in advanced human atheroma. Co-localization with interleukin-1 β-converting enzyme. Am J Pathol. 147:1995;251-266.
57. Han D., Haudenschild C., Hong M., Tinkle B., Leon M., Liau G. Evidence for apoptosis in human atherogenesis and in a rat vascular injury model. Am J Pathol. 147:1995;267-277.
58. Isner J.M., Kearney M., Bortman S., Passeri J. Apoptosis in human atherosclerosis and restenosis. Circulation. 91:1995;2703-2711.
59. Geng Y.-J., Wu Q., Muszynski M., Hansson G., Libby P. Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-gamma, tumor necrosis factor-alpha, and interleukin-1-beta. Arterioscler Thromb Vasc Biol. 16:1996;19-27.