-
1
-
-
18744375998
-
Regulation and destabilization of HIF-1α by ARD1-mediated acetylation
-
Jeong JW, Bae MK, Ahn MY, Kim SH, Sohn TK, Bae MH, et al. Regulation and destabilization of HIF-1α by ARD1-mediated acetylation. Cell 2002; 111:709-20.
-
(2002)
Cell
, vol.111
, pp. 709-720
-
-
Jeong, J.W.1
Bae, M.K.2
Ahn, M.Y.3
Kim, S.H.4
Sohn, T.K.5
Bae, M.H.6
-
2
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando D, Peet DJ, German JJ, Whelan DA, WHitelaw ML, Bruick RK. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 2002; 16:1466-71.
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
German, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
3
-
-
0034045040
-
Histone deacetylases, transcriptional control, and cancer
-
Cress WD, Seto E. Histone deacetylases, transcriptional control, and cancer. J Cell Physiol 2000; 184(1):1-16.
-
(2000)
J Cell Physiol
, vol.184
, Issue.1
, pp. 1-16
-
-
Cress, W.D.1
Seto, E.2
-
4
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3:721-32.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
5
-
-
0036359548
-
Hypoxia - A key regulatory factor in tumour growth
-
Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2:38-47.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
6
-
-
0036710591
-
Signal transduction to hypoxia-inducible factor 1
-
Semenza G. Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol 2002; 64:993-8.
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 993-998
-
-
Semenza, G.1
-
7
-
-
0032725554
-
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
-
Richard DE, Berra E, Gothie E, Roux D, Pouyssegur J. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J Biol Chem 1999; 274:32631-7.
-
(1999)
J Biol Chem
, vol.274
, pp. 32631-32637
-
-
Richard, D.E.1
Berra, E.2
Gothie, E.3
Roux, D.4
Pouyssegur, J.5
-
8
-
-
0034282553
-
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α
-
Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, et al. The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α. Cancer Res 2000; 60:4873-80.
-
(2000)
Cancer Res
, vol.60
, pp. 4873-4880
-
-
Sodhi, A.1
Montaner, S.2
Patel, V.3
Zohar, M.4
Bais, C.5
Mesri, E.A.6
-
9
-
-
12244267687
-
Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1α in gastric cancer cells
-
Park JH, Kim TY, Jong HS, Chun YS, Park JW, Lee CT, et al. Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1α in gastric cancer cells. Clin Cancer Res 2003; 9:433-40.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 433-440
-
-
Park, J.H.1
Kim, T.Y.2
Jong, H.S.3
Chun, Y.S.4
Park, J.W.5
Lee, C.T.6
-
10
-
-
0037262072
-
The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1α (HIF-1α)
-
Brune B, Zhou J. The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1α (HIF-1α). Curr Med Chem 2003; 10:845-55.
-
(2003)
Curr Med Chem
, vol.10
, pp. 845-855
-
-
Brune, B.1
Zhou, J.2
-
11
-
-
0034682786
-
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia: A mechanism of O2 sensing
-
Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, et al. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia: A mechanism of O2 sensing. J Biol Chem 2000; 275:25130-8.
-
(2000)
J Biol Chem
, vol.275
, pp. 25130-25138
-
-
Chandel, N.S.1
McClintock, D.S.2
Feliciano, C.E.3
Wood, T.M.4
Melendez, J.A.5
Rodriguez, A.M.6
-
12
-
-
0032403263
-
Increased expression of hypoxia inducible factor-1α in rat and human prostate cancer
-
Zhong H, Agani F, Baccala AA, Laughner E, RiosecoCamacho N, Isaacs WB, et al. Increased expression of hypoxia inducible factor-1α in rat and human prostate cancer. Cancer Res 1998; 58:5280-4.
-
(1998)
Cancer Res
, vol.58
, pp. 5280-5284
-
-
Zhong, H.1
Agani, F.2
Baccala, A.A.3
Laughner, E.4
Riosecocamacho, N.5
Isaacs, W.B.6
-
13
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, et al. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res 1999; 59:5830-5.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
-
14
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor- associated macrophages
-
Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, et al. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor- associated macrophages. Am J Pathol 2000; 157:411-21.
-
(2000)
Am J Pathol
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
Turley, H.2
Gatter, K.C.3
Maxwell, P.H.4
Pugh, C.W.5
Ratcliffe, P.J.6
-
15
-
-
0037320432
-
2-Methoxyestradiol, a promising anticancer agent
-
Lakhani NJ, Sarkar MA, Venitz J, Figg WD. 2-Methoxyestradiol, a promising anticancer agent. Pharmacotherapy 2003; 23:165-72.
-
(2003)
Pharmacotherapy
, vol.23
, pp. 165-172
-
-
Lakhani, N.J.1
Sarkar, M.A.2
Venitz, J.3
Figg, W.D.4
-
16
-
-
0034528890
-
2-Methoxyestradiol: An endogenous antiangiogenic and antiproliferative drug candidate
-
Pribluda VS, Gubish Jr ER, Lavallee TM, Treston A, Swartz GM, Green SJ. 2-Methoxyestradiol: An endogenous antiangiogenic and antiproliferative drug candidate. Cancer Metastasis Rev 2000; 19:173-9.
-
(2000)
Cancer Metastasis Rev
, vol.19
, pp. 173-179
-
-
Pribluda, V.S.1
Gubish Jr., E.R.2
Lavallee, T.M.3
Treston, A.4
Swartz, G.M.5
Green, S.J.6
-
17
-
-
0036645421
-
2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors α and β
-
LaVallee TM, Zhan XH, Herbstritt CJ, Kough EC, Green SJ, Pribluda VS. 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors α and β. Cancer Res 2002; 62:3691-7.
-
(2002)
Cancer Res
, vol.62
, pp. 3691-3697
-
-
LaVallee, T.M.1
Zhan, X.H.2
Herbstritt, C.J.3
Kough, E.C.4
Green, S.J.5
Pribluda, V.S.6
-
18
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003; 3:363-75.
-
(2003)
Cancer Cell
, vol.3
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
LaVallee, T.M.3
Pribluda, V.S.4
Swartz, G.M.5
Johnson, M.S.6
-
19
-
-
0037470172
-
Microtubule disruption utilizes an NFkappa B-dependent pathway to stabilize HIF-1α protein
-
Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L. Microtubule disruption utilizes an NFkappa B-dependent pathway to stabilize HIF-1α protein. J Biol Chem 2003; 278:7445-52.
-
(2003)
J Biol Chem
, vol.278
, pp. 7445-7452
-
-
Jung, Y.J.1
Isaacs, J.S.2
Lee, S.3
Trepel, J.4
Neckers, L.5
-
20
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
-
Rapisarda A, Uranchimeg B, Scudiero DA, Selby M, Sausville EA, Shoemaker RH, et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res 2002; 62:4316-24.
-
(2002)
Cancer Res
, vol.62
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
Selby, M.4
Sausville, E.A.5
Shoemaker, R.H.6
-
21
-
-
0025171293
-
Synthesis and biological evaluation of quinocarcin derivatives
-
Tokyo
-
Saito H, Kobayashi S, Uosaki Y, Sato A, Fujimoto K, Miyoshi K, et al. Synthesis and biological evaluation of quinocarcin derivatives. Chem Pharm Bull (Tokyo) 1990; 38:1278-85.
-
(1990)
Chem Pharm Bull
, vol.38
, pp. 1278-1285
-
-
Saito, H.1
Kobayashi, S.2
Uosaki, Y.3
Sato, A.4
Fujimoto, K.5
Miyoshi, K.6
-
22
-
-
0028797864
-
Efficacy of the quinocarmycins KW2152 and DX-52-1 against human melanoma lines growing in culture kand in mice
-
Plowman J, Dykes DJ, Narayanan VL, Abbott BJ, Saito H, Hirata T, et al. Efficacy of the quinocarmycins KW2152 and DX-52-1 against human melanoma lines growing in culture kand in mice. Cancer Res 1995; 55:862-7.
-
(1995)
Cancer Res
, vol.55
, pp. 862-867
-
-
Plowman, J.1
Dykes, D.J.2
Narayanan, V.L.3
Abbott, B.J.4
Saito, H.5
Hirata, T.6
-
23
-
-
0030918173
-
Disposition of DX-52-1, a novel anticancer agent, after intravenous administration to mice and dogs
-
Fuse E, Nishiie H, Kobayashi H, Ikeda S, Saito H, Covey J, et al. Disposition of DX-52-1, a novel anticancer agent, after intravenous administration to mice and dogs. Eur J Drug Metab Pharmacokinet 1997; 22:53-63.
-
(1997)
Eur J Drug Metab Pharmacokinet
, vol.22
, pp. 53-63
-
-
Fuse, E.1
Nishiie, H.2
Kobayashi, H.3
Ikeda, S.4
Saito, H.5
Covey, J.6
-
24
-
-
0037365090
-
Toxicity of a quinocarmycin analog, DX-52-1, in rats and dogs in relation to clinical outcome
-
Mirsalis JC, Schindler-Horvat J, Hill JR, Green CE, Mitoma C, Tomaszewski JE, et al. Toxicity of a quinocarmycin analog, DX-52-1, in rats and dogs in relation to clinical outcome. Cancer Chemother Pharmacol 2003; 51:193-201.
-
(2003)
Cancer Chemother Pharmacol
, vol.51
, pp. 193-201
-
-
Mirsalis, J.C.1
Schindler-Horvat, J.2
Hill, J.R.3
Green, C.E.4
Mitoma, C.5
Tomaszewski, J.E.6
-
25
-
-
0038282482
-
The hypoxia-inducible factor-1 α is a negative factor for tumor therapy
-
Unruh A, Ressel A, Mohamed HG, Johnson RS, Nadrowitz R, Richter E, et al. The hypoxia-inducible factor-1 α is a negative factor for tumor therapy. Oncogene 2003; 22:3213-20.
-
(2003)
Oncogene
, vol.22
, pp. 3213-3220
-
-
Unruh, A.1
Ressel, A.2
Mohamed, H.G.3
Johnson, R.S.4
Nadrowitz, R.5
Richter, E.6
-
26
-
-
0034892432
-
Hsp90: Chaperoning signal transduction
-
Richter K, Buchner J. Hsp90: Chaperoning signal transduction. J Cell Physiol 2001; 188:281-90.
-
(2001)
J Cell Physiol
, vol.188
, pp. 281-290
-
-
Richter, K.1
Buchner, J.2
-
27
-
-
0029789568
-
Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the Arnt transcription factor
-
Gradin K, McGuire J, Wenger RH, Kvietikova I, fhitelaw ML, Toftgard R, et al. Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the Arnt transcription factor. Mol Cell Biol 1996; 16:5221-31.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 5221-5231
-
-
Gradin, K.1
McGuire, J.2
Wenger, R.H.3
Kvietikova, I.4
Fhitelaw, M.L.5
Toftgard, R.6
-
28
-
-
0032749463
-
Hypoxia-induced activation of HIF-1: Role of HIF-1α-Hsp90 interaction
-
Minet E, Mottet D, Michel G, Roland I, Raes M, Remacle J, et al. Hypoxia-induced activation of HIF-1: Role of HIF-1α-Hsp90 interaction. FEBS Lett 1999; 460:251-6.
-
(1999)
FEBS Lett
, vol.460
, pp. 251-256
-
-
Minet, E.1
Mottet, D.2
Michel, G.3
Roland, I.4
Raes, M.5
Remacle, J.6
-
29
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 α-degradative pathway
-
Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 α-degradative pathway. J Biol Chem 2002; 277:29936-44.
-
(2002)
J Biol Chem
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
30
-
-
0036569704
-
Geldanamycin induces degradation of hypoxia-inducible factor 1α protein via the proteosome pathway in prostate cancer cells
-
Mabjeesh NJ, Post DE, Willard MT, Kaur B, Van Meir EG, Simons JW, et al. Geldanamycin induces degradation of hypoxia-inducible factor 1α protein via the proteosome pathway in prostate cancer cells. Cancer Res 2002; 62:2478-82.
-
(2002)
Cancer Res
, vol.62
, pp. 2478-2482
-
-
Mabjeesh, N.J.1
Post, D.E.2
Willard, M.T.3
Kaur, B.4
Van Meir, E.G.5
Simons, J.W.6
-
31
-
-
0035871942
-
Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells
-
Chun YS, Yeo EJ, Choi E, Teng CM, Bae JM, Kim MS, et al. Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells. Biochem Pharmacol 2001; 61:947-54.
-
(2001)
Biochem Pharmacol
, vol.61
, pp. 947-954
-
-
Chun, Y.S.1
Yeo, E.J.2
Choi, E.3
Teng, C.M.4
Bae, J.M.5
Kim, M.S.6
-
32
-
-
0038771261
-
YC-1 inhibits proliferation of human vascular endothelial cells through a cyclic GMP-independent pathway
-
Hsu HK, Juan SH, Ho PY, Liang YC, Lin CH, Teng CM, et al. YC-1 inhibits proliferation of human vascular endothelial cells through a cyclic GMP-independent pathway. Biochem Pharmacol 2003; 66:263-71.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 263-271
-
-
Hsu, H.K.1
Juan, S.H.2
Ho, P.Y.3
Liang, Y.C.4
Lin, C.H.5
Teng, C.M.6
-
33
-
-
0037414180
-
YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1
-
Yeo EJ, Chun YS, Cho YS, Kim J, Lee JC, Kim MS, et al. YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst 2003; 95:516-25.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 516-525
-
-
Yeo, E.J.1
Chun, Y.S.2
Cho, Y.S.3
Kim, J.4
Lee, J.C.5
Kim, M.S.6
-
34
-
-
0036481770
-
Von Hippel Lindau tumor suppressor and HIF-1α: New targets of NSAIDs inhibition of hypoxia-induced angiogenesis
-
Jones MK, Szabo IL, Kawanaka H, Husain SS, Tarnawski AS. von Hippel Lindau tumor suppressor and HIF-1α: New targets of NSAIDs inhibition of hypoxia-induced angiogenesis. Faseb J 2002; 16:264-6.
-
(2002)
Faseb J
, vol.16
, pp. 264-266
-
-
Jones, M.K.1
Szabo, I.L.2
Kawanaka, H.3
Husain, S.S.4
Tarnawski, A.S.5
-
35
-
-
0041464531
-
Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1α and HIF-2α in prostate cancer cells
-
Palayoor ST, Tofilon PJ, Coleman CN. Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1α and HIF-2α in prostate cancer cells. Clin Cancer Res 2003; 9:3150-7.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3150-3157
-
-
Palayoor, S.T.1
Tofilon, P.J.2
Coleman, C.N.3
-
36
-
-
0345257217
-
How to overcome (and exploit) tumor hypoxia for targeted gene therapy
-
Greco O, Marples B, Joiner MC, Scott SD. How to overcome (and exploit) tumor hypoxia for targeted gene therapy. J Cell Physiol 2003; 197:312-25.
-
(2003)
J Cell Physiol
, vol.197
, pp. 312-325
-
-
Greco, O.1
Marples, B.2
Joiner, M.C.3
Scott, S.D.4
-
37
-
-
1542464964
-
Oncolytic viruses for the therapy of brain tumors and other solid malignancies: A review
-
Fulci G, Chiocca EA. Oncolytic viruses for the therapy of brain tumors and other solid malignancies: A review. Front Biosci 2003; 8:e346-60.
-
(2003)
Front Biosci
, vol.8
-
-
Fulci, G.1
Chiocca, E.A.2
-
38
-
-
0037509944
-
A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy
-
Post DE, Van Meir EG. A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy. Oncogene 2003; 22:2065-72.
-
(2003)
Oncogene
, vol.22
, pp. 2065-2072
-
-
Post, D.E.1
Van Meir, E.G.2
-
39
-
-
0035003528
-
Gene transfer of antisense hypoxia inducible factor-1 α enhances the therapeutic efficacy of cancer immunotherapy
-
Sun X, Kanwar JR, Leung E, Lehnert K, Wang D, Krissansen GW. Gene transfer of antisense hypoxia inducible factor-1 α enhances the therapeutic efficacy of cancer immunotherapy. Gene Ther 2001; 8:638-45.
-
(2001)
Gene Ther
, vol.8
, pp. 638-645
-
-
Sun, X.1
Kanwar, J.R.2
Leung, E.3
Lehnert, K.4
Wang, D.5
Krissansen, G.W.6
|