Glutamate taste: Discrimination between the tastes of glutamate agonists and monosodium glutamate in rats

Chemical Senses

Volumn 29, Issue 4, 2004, Pages 291-299

  Delay, Eugene R ^a   Sewczak, G M ^a   Stapleton, J R ^a   Roper, S D ^b  

^a REGIS UNIVERSITY   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Amiloride; Aspartic acid; L AP4; Monosodium glutamate; NMDA; Taste discrimination; Taste thresholds

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; AMILORIDE; ASPARTIC ACID; GLUTAMATE SODIUM; IONOTROPIC RECEPTOR AGONIST; N METHYL DEXTRO ASPARTIC ACID; 2-AMINO-4-PHOSPHONOBUTYRIC ACID; AMINO ACID RECEPTOR STIMULATING AGENT; AMINOBUTYRIC ACID DERIVATIVE; N METHYLASPARTIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; TASTE ACUITY; TASTE AVERSION; TASTE BUD; TASTE DISCRIMINATION; ANIMAL; AVOIDANCE BEHAVIOR; COMPARATIVE STUDY; PERCEPTIVE DISCRIMINATION; PHYSIOLOGY; TASTE;

AMILORIDE; AMINOBUTYRIC ACIDS; ANIMALS; ASPARTIC ACID; AVOIDANCE LEARNING; DISCRIMINATION (PSYCHOLOGY); EXCITATORY AMINO ACID AGONISTS; MALE; N-METHYLASPARTATE; RATS; SODIUM GLUTAMATE; TASTE; TASTE THRESHOLD;

EID: 16644398775     PISSN: 0379864X     EISSN: None     Source Type: Journal    
DOI: 10.1093/chemse/bjh031     Document Type: Article

References (20)

1. Bigiani, A., Delay, R.J., Chaudhari, N., Kinnamon, S.C. and Roper, S.D. (1997) Responses to glutamate in rat taste cells. J. Neurophysiol., 77, 3048-3059.
2. Brand, J.G., Teeter, J.H., Kumazawa, T., Huque, T. and Bayley, D.L. (1991) Transduction mechanisms for the taste of amino acids. Physiol. Behav., 49, 899-904.
3. Brosvic, G.M. and Slotnick, B.M. (1986) Absolute and intensity-difference taste thresholds in the rat: evaluation of an automated multi-channel gustometer. Physiol. Behav., 38, 711-717.
4. Chaudhari, N., Yang, H., Lamp, C., Delay, E., Cartford, C., Than, T. and Roper, S. (1996) The taste of monosodium glutamate: membrane receptors in taste buds. J. Neurosci., 16, 3817-3826.
5. Chaudhari, N., Landin, A.M. and Roper, S.D. (2000) A metabotropic glutamate receptor variant functions as a taste receptor. Nat. Neurosci., 3, 113-119.
6. Damak, S., Rong, M., Yasumatsu, K., Kokrashvili, Z., Varadarajan, V., Zou, S., Jiang, P., Ninomiya, Y. and Margolskee, R.F. (2003) Detection of sweet and umami taste in the absence of taste receptor T1r3. Science, 301, 850-853.
7. Faurion, A. (1991) Are umami taste receptor sites structurally related to glutamate CNS receptor sites? Physiol. Behav., 49, 905-912.
8. Games, P.A. and Howell, J.F. (1976) Pairwise multiple comparison procedures with unequal n's and/or variances: a Monte Carlo study. J. Educ. Stat., 1, 113-125.
9. Geran, L.C. and Spector, A.C. (2000) Amiloride increases sodium chloride taste detection threshold in rats. Behav. Neurosci., 114, 623-634.
10. Li, X., Staszewski, L., Xu, H., Durick, K., Zoller, M. and Adler, E. (2002) Human receptors for sweet and umami taste. Proc. Natl Acad. Sci. USA, 99, 4692-4696.
11. Lin, W. and Kinnamon, S.C. (1999) Physiological evidence for inotropic and metabotropic glutamate receptors in rat taste buds. J. Neurophysiol., 82, 2061-2069.
12. Maga, J.A. (1983) Flavor potentiators. CRC Crit. Rev. Food Sci. Nutr., 18, 231-312.
13. Markison, S. and Spector, A.C. (1995) Amiloride is an ineffective conditioned stimulus in taste aversion learning. Chem. Senses, 20, 559-563.
14. Nakashima, K., Katsukawa, H., Sasamoto, K. and Ninomiya, Y. (2001) Behavioral taste similarities and differences among monosodium L-glutamate and glutamate receptor agonists in C57BL mice. J. Nutr. Sci. Vitaminol., 47, 161-166.
15. Nelson, G., Chandrashekar, J., Hoon, M.A., Feng, L., Zhao, G., Ryba, N.J.P. and Zuker, C.S. (2002) An amino-acid taste receptor. Nature, 416, 199-202.
16. Sako, N., Tokita, K., Sugimura, T. and Yamamoto, T. (2003) Synergistic responses of the chorda tympani to mixtures of umami and sweet substances in rats. Chem. Senses, 28, 261-266.
17. Stapleton, J.R., Roper, S.D. and Delay, E.R. (1999) The taste of monosodium glutamate (MSG), L-aspartic acid, and N-methyl-D aspartate (NMDA) in rats: are NMDA receptors involved in MSG taste? Chem. Senses, 24, 449-457.
18. Stapleton, J.R., Luellig, M., Roper, S.D. and Delay, E.R. (2002) Discrimination between the tastes of sucrose and monosodium glutamate in rats. Chem. Senses, 27, 375-382.
19. Yamaguchi, S. (1967) The synergistic taste effect of monosodium glutamate and disodium 5′ inosinate. J. Food Sci., 32, 473-478.
20. Zhao, G., Zhang, Y., Hoon, M.A., Chandrashekar, J., Erlenbach, I., Ryba, N.J. and Zuker, C.S. (2003) The receptors for mammalian sweet and umami taste. Cell, 115, 255-266.