Synthesis of nitrogen-functionalized cyclohexanes using chemoselective conjugate addition of phenyllithium to linear ω-nitro-α,β, ψ,ω-unsaturated ester and subsequent stereoselective intramolecular nitro-Michael cyclization

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 9, 2004, Pages 1109-1113

  Yasuhara, Tomohisa ^a   Nishimura, Katsumi ^b   Osafune, Emi ^a   Muraoka, Osamu ^a   Tomioka, Kiyoshi ^b  

^a KINKI UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Conjugate addition; Lycorane; Nitro Michael cyclization; Nitroolefin

Indexed keywords

ALKENE DERIVATIVE; ALPHA LYCORANE; BETA LYCORANE; BROMINE DERIVATIVE; CESIUM; CHEMICAL COMPOUND; CYCLOHEXANE DERIVATIVE; ESTER DERIVATIVE; FLUORIDE; GAMMA LYCORANE; LITHIUM DERIVATIVE; NITRO DERIVATIVE; NITROGEN; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG; ESTER; ORGANOMETALLIC COMPOUND; PHENYLLITHIUM;

ADDITION REACTION; ARTICLE; CHIRALITY; CONJUGATE; CYCLIZATION; MICHAEL ADDITION; STEREOCHEMISTRY; SYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION;

CYCLIZATION; CYCLOHEXANES; ESTERS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NITROGEN; ORGANOMETALLIC COMPOUNDS;

EID: 16644398427     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.52.1109     Document Type: Article

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