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15
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0038671638
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note
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2, 0 °C, 15 min, 88%.
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-
-
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16
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0038333082
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note
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3, DMF, 23 °C, 1 h, 88%.
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-
-
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17
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1942483938
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For generation of benzyne from a similar substrate in THF, see: Du, C. J. F.; Hart, H.; Ng, K. K. D. J. Org. Chem. 1986, 51, 3162.
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Du, C.J.F.1
Hart, H.2
Ng, K.K.D.3
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20
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0037995208
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note
-
The major byproduct was the corresponding debrominated indoline, obtained in yields of up to 10% (always less in amount than the Pd catalyst used in the reaction).
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-
-
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21
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0036170254
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(a) Yamada, K.; Kubo, T.; Tokuyama, H.; Fukuyama, T. Synlett 2002, 231. For similar copper-catalyzed aminations,
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Synlett
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Yamada, K.1
Kubo, T.2
Tokuyama, H.3
Fukuyama, T.4
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22
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0037178121
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For similar copper-catalyzed aminations see: (b) Klapars, A.; Huang, X.; Buchwald, S. L. J. Am. Chem. Soc. 2002, 124, 7421. (c) Kwong, F. Y.; Klapars, A.; Buchwald, S. L. Org. Lett. 2002, 4, 581.
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Klapars, A.1
Huang, X.2
Buchwald, S.L.3
-
23
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0037149057
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-
For similar copper-catalyzed aminations see: (b) Klapars, A.; Huang, X.; Buchwald, S. L. J. Am. Chem. Soc. 2002, 124, 7421. (c) Kwong, F. Y.; Klapars, A.; Buchwald, S. L. Org. Lett. 2002, 4, 581.
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Kwong, F.Y.1
Klapars, A.2
Buchwald, S.L.3
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24
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0038671640
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note
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3N, EtOAc, 23 °C, 5 min, quant.
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-
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-
25
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0014289825
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Pines, S. H.; Karady, S.; Sletzinger, M. J. Org. Chem. 1968, 33, 1758.
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Pines, S.H.1
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Sletzinger, M.3
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26
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0006977267
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Mitchell, R. H.; Lai, Y. H.; Williams, R. V. J. Org. Chem. 1979, 44, 4733.
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Mitchell, R.H.1
Lai, Y.H.2
Williams, R.V.3
-
27
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37049096674
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For a standard synthesis, see: Bolton, R. E.; Moody, C. J.; Rees, C. W.; Tojo, G. J. Chem. Soc. Chem. Commun. 1985, 1775.
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Bolton, R.E.1
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Tojo, G.4
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28
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0026740967
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Dygos, J. H.; Yonan, E. E.; Scaros, M. G.; Goodmonson, O. J.; German, D. P.; Periana, R. A.; Beck, G. R. Synthesis 1992, 741.
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Dygos, J.H.1
Yonan, E.E.2
Scaros, M.G.3
Goodmonson, O.J.4
German, D.P.5
Periana, R.A.6
Beck, G.R.7
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