Effect of a new β-sitosterol analogue on plasma lipid concentrations in rats

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 5, 2004, Pages 597-601

  Song, Yang Heon ^a   Hong, Soonil ^a   Lim, Hongsan ^a   Seo, Jinmoo ^a   Chung, Sungjoo ^a   No, Insook ^a   Lee, Kyunghee ^a   Yoon, Michung ^a  

^a Mokwon University   (South Korea)

Author keywords

sitosteryl ester derivative; Cholesterol reducing agent; Plasma lipid concentration

Indexed keywords

AMINE; CHLORIDE; DANA 87; DICYCLOHEXYLCARBODIIMIDE; FORMIC ACID DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; N (2,6 DIETHYLPHENYL)SUCCINAMIC ACID 17 (4 ETHYL 1,5 DIMETHYLHEXYL) 10,13 DIMETHYL 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 1H CYCLOPENTA[A]PHENANTHREN 3 YL ESTER; N (3 BROMOPHENYL)SUCCINAMIC ACID 17 (4 ETHYL 1,5 DIMETHYLHEXYL) 10,13 DIMETHYL 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 1H CYCLOPENTA[A]PHENANTHREN 3 YL ESTER; N (3 IODOPHENYL)SUCCINAMIC ACID 17 (4 ETHYL 1,5 DIMETHYLHEXYL) 10,13 DIMETHYL 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 1H CYCLOPENTA[A]PHENANTHREN 3 YL ESTER; N (3,4 DIMETHYLPHENYL)SUCCINAMIC ACID 17 (4 ETHYL 1,5 DIMETHYLHEXYL) 10,13 DIMETHYL 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 1H CYCLOPENTA[A]PHENANTHREN 3 YL ESTER; N (4 CHLOROPHENYL)SUCCINAMIC ACID 17 (4 ETHYL 1,5 DIMETHYLHEXYL) 10,13 DIMETHYL 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 1H CYCLOPENTA[A]PHENANTHREN 3 YL ESTER; N (4 METHOXYPHENYL)SUCCINAMIC ACID 17 (4 ETHYL 1,5 DIMETHYLHEXYL) 10,13 DIMETHYL 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 1H CYCLOPENTA[A]PHENANTHREN 3 YL ESTER; N (FLUOROPHENYL)SUCCINAMIC ACID 17 (4 ETHYL 1,5 DIMETHYLHEXYL) 10,13 DIMETHYL 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 1H CYCLOPENTA[A]PHENANTHREN 3 YL ESTER; N CYCLOHEXYLSUCCINAMIC ACID 17 (4 ETHYL 1,5 DIMETHYLHEXYL) 10,13 DIMETHYL 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 1H CYCLOPENTA[A]PHENANTHREN 3 YL ESTER; N PHENYLSUCCINAMIC ACID 17 (4 ETHYL 1,5 DIMETHYLHEXYL) 10,13 DIMETHYL 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 1H CYCLOPENTA[A]PHENANTHREN 3 YL ESTER; N TOLYLSUCCINAMIC ACID 17 (4 ETHYL 1,5 DIMETHYLHEXYL) 10,13 DIMETHYL 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 1H CYCLOPENTA[A]PHENANTHREN 3 YL ESTER; SITOSTEROL; SITOSTEROL DERIVATIVE; SUCCINIC ACID MONO[17 (4 ETHYL 1,5 DIMETHYLHEXYL) 10,13 DIMETHYL 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 1H CYCLOPENTA[A]PHENANTHREN 3 YL]ESTER; SUCCINIC ANHYDRIDE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

AMINATION; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL REACTION; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; LIPID BLOOD LEVEL; MALE; NONHUMAN; RAT; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; CHEMISTRY; DRUG ANTAGONISM; SPRAGUE DAWLEY RAT;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; MALE; RATS; RATS, SPRAGUE-DAWLEY; SITOSTEROLS;

EID: 16544388398     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.52.597     Document Type: Article

References (24)

1. In memory of the late Professor LeRoy H. Klemm.
2. Jaeger B. R., Seidel D., Herz, 26, 531-544 (2001).
3. Assmann G., Cullen P., Schulte H., Atherosclerosis, 130 (Suppl. 1), S22 (1997).
4. Shepherd J., Lancet, 359, 2271-2273 (2002).
5. Jones P., Kafonek S., Laurora I., Hunniganhake D., Am. J. Cardiol., 81, 582-587 (1998).
6. Miki T., Kori M., Mabuchi H., Tozawa R., Nishimoto T., Sugiyama Y., Teshima K., Yukimasa H., J. Med. Chem., 45, 4571-4580 (2002).
7. Chan C., Andreotti D., Cox B., Kirk B. E., Lester M. G., McCarthy A. D., Procopiou P. A., Ross B. C., J. Med. Chem., 39, 207-216 (1996).
8. Burnett D. A., Caplen M. A., Davis H. R., Jr., Burrier R. E., Clader J. W., J. Med. Chem., 37, 1733-1736 (1994).
9. McCarthy P. A., DeNinno M. P., Morehouse L. A., Chandler C. E., Bangerter F. W., Wilson T. C., Urban F. J., Walinsky S. W., Cosgrove P. G., Duplantier K., Etienne J. B., Fowler M. A., Lambert J. F., O'Donnell J. P., Pezzullo S. L., Watson H. A., Wilkins R. W., Zaccaro L. M., Zawistoski M. P., J. Med. Chem., 39, 1935-1937 (1996).
10. Ling W. H., Jones P. J. H., Atherosclerosis, 118, 319-331 (1995).
11. Becker M., Staab D., von Bergmann K., J. Pediatr., 122, 292-296 (1993).
12. Heinemann T., Axtmann G., von Bergmann K., Eur. J. Clin. Invest., 23, 827-831 (1993).
13. Laraki L., Pelletier X., Debry G., Ann. Nutr. Metab., 35, 221-225 (1991).
14. Wasan K. M., Najafi S., Peteherych K. D., Pritchard P. H., J. Pharm. Sci., 90, 1795-1799 (2001).
15. Habib N. S., Khalil M. A., Arch. Pharm., 323, 401-404 (1990).
16. Heinemann T., Leiss O., von Bergmann K., Atherosclerosis, 61, 219-223 (1986).
17. Wasan K. M., Peteherych K. D., Najafi S., Zamfier C., Pritchard P. H., J. Pharm. Pharmaceut. Sci., 4, 207-216 (2001).
18. Berge K. E., Tian H., Graf G. A., Yu L., Grishin N. V., Schultz J., Kwitwrrovich P., Shan B., Barnes R., Hobbs H. H., Science, 290, 1771-1775 (2000).
19. Simons K., Ikonen E., Science, 290, 1721-1725 (2000).
20. Repa J. J., Turley S. D., Lobaccaro J.-M. A., Medina J., Li L., Lustig K., Shan B., Heyman R. A., Dietschy J. M., Mangelsdorf D. J., Science, 289, 1524-1529 (2000).
21. Malini T., Vanithakumari G., J. Ethnopharm., 36, 51-55 (1992).
22. Moghadasian M. H., MaManus B. M., Godin D. V., Rodrigues B., Frohlich J. J., Circulation, 99, 1733-1739 (1999).
23. Moghadasian M. H., Frohlich J. J., Am. J. Med., 107, 588-594 (1999).
24. Moghadasian M. H., MaManus B. M., Pritchard P. H., Frohlich J. J., Arterioscler. Thromb. Vasc. Biol., 17, 119-126 (1997).