Assessing the plasma pharmacokinetics, tissue distribution, excretion and effects on cholesterol pharmacokinetics of a novel hydrophilic compound, FM-VP4, following administration to rats

Journal of Pharmacy and Pharmaceutical Sciences

Volumn 4, Issue 3, 2001, Pages 207-216

  Wasan, Kishor M ^a   Peteherych, Kathy D ^a   Najafi, Soheila ^a   Zamfir, Catalina ^a   Pritchard, P Haydn ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CHOLESTEROL ESTER; FM VP4; INTRALIPID; STANOL ESTER; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DIET RESTRICTION; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EXCRETION; DRUG FECES LEVEL; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG TISSUE LEVEL; DRUG URINE LEVEL; GASTROINTESTINAL TRACT; HYDROPHILICITY; LIPID ABSORPTION; MALE; MASS SPECTROMETRY; NONHUMAN; POSTOPERATIVE PERIOD; RADIATION DETECTION; RAT; THIN LAYER CHROMATOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; DRUG ADMINISTRATION SCHEDULE; INFUSIONS, INTRAVENOUS; MALE; PHYTOSTEROLS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; TISSUE DISTRIBUTION; TRITIUM;

EID: 0035735021     PISSN: 14821826     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. High risk strategies for atherosclerosis
2. Dietary sterols: Their relationships to atherosclerosis
3. Cholesterol, phytosterol and polyunsaturated fatty acid levels in 1982 and 1957 Japanese diets
4. Effects of dietary phytosterols on cholesterol metabolism and atherosclerosis: Clinical and experimental evidence
5. Proatherogenic and antiatherogenic effects of probucol and phytosterols in apoE-deficient mice: Possible mechanisms of action
6. "Tail-Oil"-derived phytosterols reduce atherosclerosis in ApoE-deficient mice
7. Assessing plasma pharmacokinetics of cholesterol following oral coadministration with a novel vegetable stanol mixture to fasting rats
8. Comparison of intestinal absorption of cholesterol with different plant sterols in man
9. Inhibition of cholesterol absorption in rats by plant sterols
10. Comparison between permeability coefficients in rat and human jejunum
11. Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
12. Estimation of oral drug absorption in man based on intestine permeability in rats
13. The validation of the intestinal permeability approach to predict oral fraction of dose absorbed in humans and rats
14. Intestinal absorption and biliary secretion of cholesterol in rats with nephrotic syndrome
15. Assays of Lecithin Cholesterol Acyltransferase (LCAT)
16. Chronic collection of mesenteric lymph from conscious tethered rats
17. Structure, assembly and secretion of lipoproteins
18. LAGRAN program for area and moments in pharmacokinetic analysis
19. Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans
20. Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol
21. Long-term treatment of severe familial hypercholesterolemia in children: Effects of sitosterol and bezafibrate
22. The effects of sitosterol on the metabolism of cholesterol and lipids in rats on a diet low in fat
23. Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine: Women and dietary sitostanol
24. Effects of inhibiting cholesterol absorption and synthesis on cholesterol and lipoprotein metabolism in hypercholesterollemic non-insulin dependent diabetic men
25. Cholesterol reduction by different plant stanol mixtures and with variable fat intake
26. Sitostanol ester margarine in dietary treatment of children with familial hypercholesterolemia
27. Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolemic NIDDM patients before and during sitostanol ester-margarine treatment
28. Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects
29. Reduction of serum cholesterol with sitostanol-ester margarine is a mildly hypercholesterolemic population
30. Histologic, hematologic, and biochemical characteristics of apo E-deficient mice: Effects of dietary cholesterol and phytosterols
31. Lack of regression of atherosclerotic leisions in phytosterol-treated apo E-deficient mice
32. Effects of a "tall-oil"-derived phytosterol mixture on the development of atherosclerotic leisons in apo E-deficient mice
33. Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolemic and mildly hypercholesterolemic subjects
34. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic man
35. Evidence for a nonabsorptive antihypercholesterolemic action of phytosterols in the chicken
36. Effect of soybean sterols in the diet on plasma and liver cholesterol in chicks
37. Serum levels, absorption efficacy, fecal elimination and synthesis of cholesterol during increasing dosing of dietary sitostanol esters in hypercholesterolemic subjects
38. Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apo E phenotypes during dietary sitostanol ester treatment
39. Serum lipoproteins and lecithin: Cholesterol acyltransferase (LCAT) activity in hypercholesterolemic subjects given β-sitosterol
40. Dietary olive oil reduces low-density lipoprotein uptake by macrophages and decreases the susceptibility of the lipoprotein to undergo lipid peroxidation
41. Incorporation of liposomal phytosterols into human cells in culture: A potential in vitro model for investigating pathological effects of phytosterolemia
42. Effects of micellar sitosterol on cholesterol metabolism in Caco-2 cells
43. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
44. Regulation of Absorption and ABC1-mediated efflux of cholesterol of RXR Heterodimers
45. How cells handle cholesterol