Cellular Disorganization and Extensive Apoptosis in the Developing Heart of Mice that Lack Cardiac Muscle α-Actin: Apparent Cause of Perinatal Death

Pediatric Research

Volumn 55, Issue 2, 2004, Pages 197-204

  Abdelwahid, Eltyeb ^a,b,e   Pelliniemi, Lauri J ^a   Szucsik, John C ^c   Lessard, James L ^c   Jokinen, Eero ^d  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF CINCINNATI   (United States)

^d UNIVERSITY OF HELSINKI   (Finland)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; APOPTOSIS INHIBITOR; ISOPROTEIN; PROTEIN BCL XL; PROTEIN P53;

ACTIN FILAMENT; ACTIN MYOSIN INTERACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CAUSE OF DEATH; CELL ULTRASTRUCTURE; CONTROLLED STUDY; EMBRYO; EMBRYO MORTALITY; FEMALE; FETUS; HEART DEVELOPMENT; HEART MUSCLE CELL; HEART WORK; HISTOPATHOLOGY; HOMOZYGOTE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NEWBORN; NICK END LABELING; NONHUMAN; PERINATAL DEATH; POSTNATAL DEVELOPMENT; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION; WILD TYPE;

ACTINS; ANIMALS; APOPTOSIS; CAUSE OF DEATH; FEMALE; HEART; HEART DEFECTS, CONGENITAL; MALE; MICE; MICE, MUTANT STRAINS; MICROFILAMENTS; MYOCARDIUM; PREGNANCY;

EID: 1642555922     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000100900.56627.E1     Document Type: Article

References (41)

1. Vandekerckhove J, Weber K 1979 The complete amino acid sequence of actins from bovine aorta, bovine heart, bovine fast skeletal muscle, and rabbit slow skeletal muscle. A protein-chemical analysis of muscle actin differentiation. Differentiation 14:123-133
2. Alonso S, Garner I, Vandekerckhove J, Buckingham M 1990 Genetic analysis of the interaction between cardiac and skeletal actin gene expression in striated muscle of the mouse. J Mol Biol 211:727-738
3. Vandekerckhove J, Bugaisky G, Buckingham M 1986 Simultaneous expression of skeletal muscle and heart actin proteins in various striated muscle tissues and cells. A quantitative determination of the two actin isoforms. J Biol Chem 261:1838-1843
4. Ordahl CP 1986 The skeletal and cardiac alpha-actin genes are coexpressed in early embryonic striated muscle. Dev Biol 117:488-492
5. Ruzicka DL, Schwartz RJ 1988 Sequential activation of alpha-actin genes during avian cardiogenesis: vascular smooth muscle alpha-actin gene transcripts mark the onset of cardiomyocyte differentiation. J Cell Biol 107:2575-2586
6. Sassoon DA, Garner I, Buckingham M 1988 Transcripts of alpha-cardiac and alpha-skeletal actins are early markers for myogenesis in the mouse embryo. Development 104:155-164
7. Lyons GE, Buckingham ME, Mannherz HG 1991 α-Actin proteins and gene transcripts are colocalized in embryonic mouse muscle. Development 111:451-454
8. McHugh KM, Crawford K, Lessard JL 1991 A comprehensive analysis of the developmental and tissue-specific expression of the isoactin multigene family in the rat. Dev Biol 148:442-458
9. Boheler KR, Carrier L, de la Bastie D, Allen PD, Komajda M, Mercadier JJ, Schwartz K 1991 Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts. J Clin Invest 88:323-330
10. Herman IM 1993 Actin isoforms. Curr Opin Cell Biol 5:48-55
11. Lu MH, DiLullo C, Schuhheiss T, Holtzer S, Murray JM, Choi J, Fischman DA, Holtzer H 1992 The vinculin/sarcomeric-alpha-actinin/alpha-actin nexus in cultured cardiac myocytes. J Cell Biol 117:1007-1022
12. Mogensen J, Klausen IC, Pedersen AK, Egeblad H, Bross P, Kruse TA, Gregersen N, Hansen PS, Baandrup U, Borglum AD 1999 Alpha-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy. J Clin Invest 103:R39-R43
13. Bonne G, Carrier L, Richard P, Hainque B, Schwartz K 1998 Familial hypertrophic cardiomyopathy: from mutations to functional defects. Circ Res 83:580-593
14. Marian AJ, Roberts R 1998 Familial hypertrophic cardiomyopathy: a paradigm of the cardiac hypertrophic response to injury. Ann Med 3:24-32
15. Olson TM, Michels VV, Thibodeau SN, Tai YS, Keating MT 1998 Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. Science 280:750-752
16. Rengan R, Ochs HD, Sweet LI, Keil ML, Gunning WT, Lachant NA, Boxer LA, Omann GM 2000 Actin cytoskeletal function is spared, but apoptosis is increased, in WAS patient hematopoietic cells. Blood 95:1283-1292
17. Mashima T, Naito M, Noguchi K, Miller DK, Nicholson DW, Tsuruo T 1997 Actin cleavage by CPP-32/apopain during the development of apoptosis. Oncogene 14:1007-1012
18. White SR, Williams P, Wojcik KR, Sun S, Hiemstra PS, Rabe KF, Dorscheid DR 2001 Initiation of apoptosis by actin cytoskeletal derangement in human airway epithelial cells. Am J Respir Cell Mol Biol 24:282-294
19. Yamazaki Y, Dang Y, Shang X, Tsuruga M, Fujita Y, Tanaka H, Zhou D, Kawasaki K, Oka S 2000 Acceleration of DNA damage-induced apoptosis in leukemia cells by interfering with actin system. Exp Hematol 28:1491
20. Rubtsova SN, Kondratov RV, Kopnin PB, Chumakov PM, Kopnin BP, Vasiliev JM 1998 Disruption of actin microfilaments by cytochalasin D leads to activation of p53. FEBS Lett 430:353-357
21. Suarez-Huerta N, Mosselmans R, Dumont JE, Robaye B 2000 Actin depolymerization and polymerization are required during apoptosis in endothelial cells. J Cell Physiol 184:239-245
22. Brown SB, Bailey K, Savill J 1997 Actin is cleaved during constitutive apoptosis. Biochem J 323:233-237
23. Guenal I, Risler Y, Mignotte B 1997 Down-regulation of actin genes precedes microfilament network disruption and actin cleavage during p53-mediated apoptosis. J Cell Sci 110:489-495
24. Colucci WS 1997 Molecular and cellular mechanisms of myocardial failure. Am J Cardiol 80:15L-25L
25. Narula J, Haider N, Virmani R, DiSalvo TG, Kolodgie FD, Hajjar RJ, Schmidt U, Semigran MJ, Dec W, Khaw BN 1996 Apoptosis in myocytes in end-stage heart failure. N Engl J Med 335:1182-1189
26. Kumar A, Crawford K, Close L, Madison M, Lorenz J, Doetschman T, Pawlowski S, Duffy J, Neumann J, Robbins J, Boivin GP, O'Toole BA, Lessard JL 1997 Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin. Proc Natl Acad Sci U S A 94:4406-4411
27. Billig H, Futura I, Hsueh AJ 1994 Gonadotropin-releasing hormone directly induces apoptotic cell death in the rat ovary: biochemical and in situ detection of deoxyribonucleic acid fragmentation in granulosa cells. Endocrinology 134:245-252
28. Hsu SM, Raine L, Fanger H 1981 The use of antiavidin antibody and avidin-biotin peroxidase complex in immunoperoxidase technics. Am J Clin Pathol 75:816-821
29. Cahir-McFarland ED, Davidson DM, Schauer SL, Duong J, Kieff E 2000 NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells. Proc Natl Acad Sci U S A 97:6055-6060
30. Webb BL, Jimenez E, Martin GS 2000 v-Src generates a p53-independent apoptotic signal. Mol Cell Biol 20:9271-9280
31. Kubalak SW, Miller-Hance WC, O'Brien TX, Dyson E, Chien KR 1994 Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. J Biol Chem 269:16961-16970
32. Fröjdman K, Paranko J, Virtanen I, Pelliniemi LJ 1992 Intermediate filaments and epithelial differentiation of male rat embryonic gonad. Differentiation 50:113-123
33. Abdelwahid E, Pelliniemi LJ, Jokinen E 2002 Cell death and differentiation in the development of the endocardial cushion of the embryonic heart. Microsc Res Tech 58:395-403
34. Poelmann RE, Molin D, Wisse LJ, Gittenberger-de Groot AC 2000 Apoptosis in cardiac development. Cell Tissue Res 301:43-52
35. van den Hoff MJ, van den Eijnde SM, Viragh S, Moorman AF 2000 Programmed cell death in the developing heart. Cardiovase Res 45:603-620
36. Wyllie AH, Kerr JFR, Currie AR 1980 Cell death: the significance of apoptosis. Int Rev Cytol 68:251-306
37. Holmes KC, Popp D, Gebhard W, Kabsch W 1990 Atomic model of the actin filament. Nature 347:44-49
38. Abraham WT, Bristow MR 1997 Specialized centers for heart failure management. Circulation 96:2755-2757
39. Abdelwahid E, Eriksson M, Pelliniemi LJ, Jokinen E 2001 Heat shock proteins, HSP25 and HSP70, and apoptosis in developing endocardial cushion of the mouse heart. Histochem Cell Biol 15:95-104
40. Abdelwahid E, Rice D, Pelliniemi LJ, Jokinen E 2001 Overlapping and differential localization of Bmp-2, Bmp-4, Msx-2 and apoptosis in the endocardial cushion and adjacent tissues of the developing mouse heart. Cell Tissue Res 305:67-78
41. Abdelwahid E, Pelliniemi LJ, Niinikoski H, Simell O, Tuominen J, Rahkonen O, Jokinen E 1999 Apoptosis in the pattern formation of the ventricular wall during mouse heart organogenesis. Anat Rec 256:208-217