Effects of Fluoranthene, a Polycyclic Aromatic Hydrocarbon, on cAMP-Dependent Anion Secretion in Human Airway Epithelia

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 2, 2004, Pages 651-657

  Ito, Yasushi ^a   Son, Masami ^a   Sato, Shinji ^a   Ohashi, Takamasa ^a   Kondo, Masashi ^a   Shimokata, Kaoru ^a   Kume, Hiroaki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; ANION; ANTHRACENE; BENZO[A]PYRENE; BICARBONATE; CALCIUM; CHARYBDOTOXIN; CHLORIDE; CHLORIDE CHANNEL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENZYME INHIBITOR; FLUORANTHENE; FLUORENE DERIVATIVE; FORSKOLIN; ISOPRENALINE; KCA4 CHANNEL; ORGANIC ANION TRANSPORTER; POLYCYCLIC AROMATIC HYDROCARBON; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

AIR POLLUTANT; ARTICLE; BASOLATERAL MEMBRANE; CALCIUM CELL LEVEL; CELL CULTURE; CELL STRAIN; CELL STRAIN CALU 3; CHEMISTRY; CHLORIDE TRANSPORT; CONTROLLED STUDY; CYTOLOGY; CYTOSOL; DRUG EFFECT; EPITHELIUM; HUMAN; HUMAN CELL; ION TRANSPORT; METABOLISM; POTASSIUM CURRENT; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RESPIRATORY SYSTEM; UPREGULATION;

ANIONS; CALCIUM; CELLS, CULTURED; CHLORIDE CHANNELS; CYCLIC AMP; ENZYME INHIBITORS; EPITHELIUM; FLUORENES; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; ORGANIC ANION TRANSPORTERS; POLYCYCLIC HYDROCARBONS, AROMATIC; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RESPIRATORY SYSTEM;

EID: 1642498173     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.059089     Document Type: Article

References (38)

1. Devor DC, Singh AK, Lambert LC, Deluca A, Frizzell RA, and Bridges RJ (1999) Bicarbonate and chloride secretion in Calu-3 human airway epithelial cells. J Gen Physiol 113:743-760.
2. Diaz-Sanchez D, Penichet-Garcia M, and Saxon A (2000) Diesel exhaust particles directly induce activated mast cells to degranulate and increase histamine levels and symptom severity. J Allergy Clin Immunol 106:1140-1146.
3. Fromme H, Oddoy A, Piloty M, Krause M, and Lahrz T (1998) Polycyclic aromatic hydrocarbons (PAH) and diesel engine emission (elemental carbon) inside a car and a subway train. Sci Total Environ 217:165-173.
4. Gasiewicz TA, Kende AS, Rucci G, Whitney B, and Willey JJ (1996) Analysis of structural requirements for Ah receptor antagonist activity: ellipticines, flavones and related compounds. Biochem Pharmacol 52:1787-1803.
5. Gerlach AC, Gangopadhyay NN, and Devor DC (2000) Kinase-dependent regulation of the intermediate conductance, calcium-dependent potassium channel, hIK1. J Biol Chem 275:585-598.
6. Goldman R, Enewold L, Pellizzari E, Beach JB, Bowman ED, Krishnan SS, and Shields PG (2001) Smoking increases carcinogenic polycyclic aromatic hydrocarbons in human lung tissue. Cancer Res 61:6367-6371.
7. Gross E, Fedotoff O, Pushkin A, Abuladze N, Newman D, and Kurtz I (2003) Phosphorylation-induced modulation of pNBC1 function: distinct roles for the amino- and carboxy-termini. J Physiol 549:673-682.
8. - conductance. Am J Physiol 266:L502-L512.
9. Hoffmann D and Hoffmann I (1997) The changing cigarette, 1950-1995. J Toxicol Environ Health 50:307-364.
10. Hunt JF, Fang K, Malik R, Snyder A, Malhotra N, Platts-Mills TA, and Gaston B (2000) Endogenous airway acidification. Implications for asthma pathophysiology. Am J Respir Crit Care Med 161:694-699.
11. Inglis SK, Finlay L, Ramminger SJ, Richard K, Ward MR, Wilson SM, and Olver RE (2002) Regulation of intracellular pH in Calu-3 human airway cells. J Physiol 538:527-539.
12. Inglis SK, Wilson SM, and Olver RE (2003) Secretion of acid and base equivalents by intact distal airways. Am J Physiol 284:L855-L862.
13. + conductance in human airway epithelial cells. J Pharmacol Exp Ther 302:80-87.
14. Ito Y, Sato S, Son M, Kume H, Takagi K, and Yamaki K (2002b) Bioelectric toxicity caused by chlorpromazine in human lung epithelial cells. Toxicol Appl Pharmacol 183:198-206.
15. - secretion in human airway epithelial Calu-3 cells. Toxicol Appl Pharmacol 176:101-109.
16. Jayaraman S, Song Y, Vetrivel L, Shankar L, and Verkman AS (2001) Noninvasive in vivo fluorescence measurement of airway-surface liquid depth, salt concentration and pH. J Clin Investig 107:317-324.
17. 2+ of airway epithelial cells. Am J Respir Cell Mol Biol 25:78-83.
18. Kendall M, Duarte A, Rocha-Santos T, Hamilton R, and Williams I (2002) Airborne particulate-associated polyaromatic hydrocarbons, n-alkanes, elemental and organic carbon in three European cities. J Environ Monit 4:890-896.
19. Kostikas K, Papatheodorou G, Ganas K, Psathakis K, Panagou P, and Loukides S (2002) pH in expired breath condensate of patients with inflammatory airway diseases. Am J Respir Crit Care Med 165:1364-1370.
20. Krieger JA, Born JL, and Burchiel SW (1994) Persistence of calcium elevation in the HPB-ALL human T cell line correlates with immunosuppressive properties of polycyclic aromatic hydrocarbons. Toxicol Appl Pharmacol 127:268-274.
21. Krieger JA, Davila DR, Lytton J, Born JL, and Burchiel SW (1995) Inhibition of sarcoplasmic/endoplasmic reticulum calcium ATPases (SERCA) by polycyclic aromatic hydrocarbons in HPB-ALL human T cells and other tissues. Toxicol Appl Pharmacol 133:102-108.
22. - cotransporter. Am J Physiol 282:C817-C823.
23. Lee PS, Gorski RA, Hering WE, and Chan TL (1987) Lung clearance of inhaled particles after exposure to carbon black generated from a resuspension system. Environ Res 43:364-373.
24. - and protein kinase C-delta in Calu-3 cells. Am J Physiol 282: L1151-L1159.
25. Lodovici M, Akpan V, Giovannini L, Migliani F, and Dolara P (1998) Benzo[a]pyrene diol-epoxide DNA adducts and levels of polycyclic aromatic hydrocarbons in autoptic samples from human lungs. Chem Biol Interact 116:199-212.
26. Matsumoto H and Kashimoto T (1985) Average daily respiratory intake of polycyclic aromatic hydrocarbons in ambient air determined by capillary gas chromatography. Bull Environ Contam Toxicol 34:17-23.
27. Reddy MM and Quinton PM (2001) cAMP-independent phosphorylation activation of CFTR by G proteins in native human sweat duct. Am J Physiol 280:C604-C613.
28. - cotransporters: cloning and physiology. Annu Rev Physiol 61:699-723.
29. Sagai M, Furuyama A, and Ichinose T (1996) Biological effects of diesel exhaust particles (DEP). III. Pathogenesis of asthma like symptoms in mice. Free Radic Biol Med 21:199-209.
30. Shimura S (2000) Signal transduction of mucous secretion by bronchial gland cells. Cell Signal 12:271-277.
31. Smith JJ and Welsh MJ (1992) cAMP stimulates bicarbonate secretion across normal, but not cystic fibrosis airway epithelia. J Clin Investig 89:1148-1153.
32. Sun JD, Wolff RK, Kanapilly GM, and McClellan RO (1984) Lung retention and metabolic fate of inhaled benzo(a)pyrene associated with diesel exhaust particles. Toxicol Appl Pharmacol 73:48-59.
33. Sydbom A, Blomberg A, Parnia S, Stenfors N, Sandstrom T, and Dahlen SE (2001) Health effects of diesel exhaust emissions. Eur Respir J 17:733-746.
34. Tamaoki J, Isono K, Sakai N, Kanemura T, and Konno K (1992) Erythromycin inhibits Cl secretion across canine tracheal epithelial cells. Eur Respir J 5:234-238.
35. 2+ and cell proliferation in primary human mammary epithelial cells. Carcinogenesis 18:1177-1182.
36. Tate S, MacGregor G, Davis M, Innes JA, and Greening AP (2002) Airways in cystic fibrosis are acidified: detection by exhaled breath condensate. Thorax 57:926-929.
37. Waldman JM, Lioy PJ, Greenberg A, and Butler JP (1991) Analysis of human exposure to benzo(a)pyrene via inhalation and food ingestion in the Total Human Environmental Exposure Study (THEES). J Expo Anal Environ Epidemiol 1:193-225.
38. Yamaguchi K, Near R, Shneider A, Cui H, Ju ST, and Sherr DH (1996) Fluoranthene-induced apoptosis in murine T cell hybridomas is independent of the aromatic hydrocarbon receptor. Toxicol Appl Pharmacol 139:144-152.