Fluoranthene-induced apoptosis in murine T cell hybridomas is independent of the aromatic hydrocarbon receptor

Toxicology and Applied Pharmacology

Volumn 139, Issue 1, 1996, Pages 144-152

  Yamaguchi, Koichi ^a   Near, Richard ^a   Shneider, Alexander ^a   Cui, Haili ^a   Ju, Shyr Te ^a   Sherr, David H ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; EGTAZIC ACID; FLUORANTHENE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; HYBRIDOMA; IMMUNOTOXICITY; MOUSE; NONHUMAN; T LYMPHOCYTE;

ANIMALIA; MURINAE;

EID: 0030200744     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0153     Document Type: Article

References (54)

1. Abbott, B. D., Perdew, G. H., and Birnbaum, L. S. (1994). Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. Toxicol. App. Pharmacol. 126, 16-25.
2. Archuleta, M. M., Schieven, G. L., Ledbetter, J. A., Deanin, G. G., and Burchiel, S. W. (1993). 7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-γ1, formation of inositol 1,4,5-triphosphate, and mobilization of intracellular calcium. Proc. Natl. Acad. Sci. USA 90, 6105-6109.
3. Barfknecht, T. R., Andon, B. M., Bishop, W. W., and Thilly, W. G. (1981). Radiosterilization of rat liver microsome containing postmitochondrial supernatant for mutation assays. Environ. Mutag. 3, 565-573.
4. Bigelow, S. W., and Nebert, D. W. (1982). The Ah regulatory gene product. Survey of nineteen polycyclic aromatic compounds' and fifteen benzo[α]pyrene metabolites capacity to bind to the cytosolic receptor. Toxicol. Lett. 10, 109-118.
5. Blank, J. A., Tucker, A. N., Sweatlock, J., Gasiewicz, T. A., and Luster, M. I. (1987). α-Naphthoflavone antagonisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced murine lymphocyte ethoxyresorufin-O-deethylase activity and immunosuppression. Mol Pharmacol. 32, 168-172.
6. Burchiel, S. W., Davis, D. A. P., Ray, S. D., and Barton, S. L. (1993). DMBA induces programmed cell death (apoptosis) in the A20.1 murine B cell lymphoma. Fundam. Appl. Toxicol. 21, 120-124.
7. Burchiel, S. W., Davis, D. P., Ray, S. D., Archuleta, M. M., Thilsted, J. P., and Corcoran, G. B. (1992). DMBA-mduced cytotoxicity in lymphoid and nonlymphoid organs of B6C3F1 mice: Relation of cell death to intracellular calcium and DNA damage. Toxicol. Appl. Pharmacol. 113, 126-132.
8. Cohen, J. J. (1991). Programmed cell death in the immune system. Adv. Immunol. 50, 55.
9. Crespi, C. L., Altman, J. D., and Marletta, M. A. (1985). Xenobiotic metabolism and mutation in a human lymphoblastoid cell line. Chem.-Biol. Interact. 53, 257-272.
10. 2+-associated signaling pathways in the immunotoxicity of polycyclic aromatic hydrocarbons. J. Toxicol. Environ. Health 44, 101-126.
11. Dolwick, K. M., Swanson, H. I., and Bradfield, C. A. (1993). In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition. Proc. Natl. Acad. Sci. USA 90, 8566-8570.
12. Ema, M., Sogawa, K., Watanabe, N., Chujoh, Y., Matsushita, N., Gotoh, O., Funae, Y., and Fujii-Kuriyama, Y. (1992). cDNA cloning and structure of mouse putative Ah receptor. Biochem. Biophys. Res. Commun. 184, 246-253.
13. Enan, E., and Matsumura, F. (1995). Evidence for a second pathway in the action mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Significance of Ah-receptor mediated activation of protein kinase under cell-free conditions. Biochem. Pharmacol. 49, 249-261.
14. Gillette-Ferguson, I., and Sidman, C. L. (1994). A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice. Eur. J. Immunol. 24, 1181-1185.
15. Greenlee, W. F., Dold, K. M., Irons, R. D., and Osborne, R. (1985). Evidence for direct action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thymic epithelium. Toxicol. App. Pharmacol. 79, 112-120.
16. Hardin, J. A., Hinoshita, F., and Sherr, D. H. (1992). Mechanisms by which benzo[α]pyrene, an environmental carcinogen, suppresses B cell lymphopoiesis. Toxicol. App. Pharmacol. 117, 155-164.
17. Hinoshita, F., Hardin, J. A., and Sherr, D. H. (1992). Fluoranthene induces programmed cell death and alters growth of immature B cell populations in bone marrow cultures. Toxicology 73, 203-218.
18. Holsapple, M. (1995). Role of calcium in 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD)-induced suppression of B-cell function. Toxicologist 15, 45.
19. Holsapple, M. P., Morris, D. L., Wood, S. C., and Snyder, N. K. (1991). 2,3,7,8-Tetrachloro-dibenzo-p-dioxin-induced changes in immunocompetence: Possible mechanisms. Annu. Rev. Pharmacol. Toxicol. 31, 73-100.
20. Hunter, T., and Pines, J. (1994). Cyclins and cancer II: Cyclin D and CDK inhibitors come of age. Cell 79, 573-582.
21. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans (1983), Vol. 32. International Agency for Research on Cancer, Lyon.
22. Ju, S.-T., Panka, D. J., Cui, H., Ettinger, R., E-Khatib, M, Sherr, D. H., Stanger, B. Z., and Marshak-Rothstem, A. (1995). Fas (CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373, 444-448.
23. Kamesaki, H., Zwiebel, J. A., Reed, J. C., and Cossman, J. (1994). Role of bcl-2 and IL-5 in the regulation of anti-IgM-induced growth arrest and apoptosis in immature B cell lines. J. Immunol. 152, 3294-3305.
24. Karras, J. G., and Holsapple, M. P. (1994). Mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced disruption of B-lymphocyte signaling in the mouse: A current perspective. Exp. Clin. Immunogenet. 11, 110-118.
25. Kawabata, T., and White, K. L., Jr. (1987). Suppression of the in vitro humoral immune response of mouse splenocytes by benzo[α]pyrene metabolites and inhibition by α-naphthaflavone. Cancer Res. 47, 22317-22322.
26. Kerkvliet, N. I., Baecher-Steppan, L., Smith, B. B., Youngberg, J. A., Henderson, M. C., and Buhler, D. R. (1990a). Role of the Ah locus in suppression of cytotoxic lymphocyte activity by halogenated aromatic hydrocarbons (PCBs and TCDD): Structure-activity relationships and effects in C57BL/6 mice congenic at the Ah locus. Fundam. Appl. Toxicol. 14, 532.
27. Kerkvliet, N. I., Steppan, L. B., Brauner, J. A., Deyo, H. A., Henderson, M. C., Tomar, R. S., and Buhler, D. R. (1990b). Influence of the Ah locus on the humoral immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: Evidence for Ah-receptor-dependent and Ah-receptor-independent mechanisms of immunosuppression. Toxicol. Appl. Pharmacol. 105, 26-36.
28. Kerr, J. F. R., Wyllie, A. H., and Currie, A. R. (1972). Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239.
29. Kremer, J., Gleichmann, E., and Esser, C. (1994). Thymic stroma exposed to arylhydrocarbon receptor-binding xenobiotics fails to support proliferation of early thymocytes but induces differentiation. J. Immunol. 153, 2778-2786.
30. Krieger, J. A., Born, J. L., and Burchiel, S. W. (1994). Persistence of calcium elevation in the HPB-ALL human T cell line correlates with immunosuppressive properties of polycyclic aromatic hydrocarbons. Toxicol. Appl. Pharmacol. 127, 268-274.
31. LaVoie, E. J., Cai, Z. W., Meschter, C. L., and Weyland, E. H. (1994). Tumorigenic activity of fluoranthene, 2-methylfluoranthene and 3-methylfluoranthene in newborn CD-1 mice. Carcinogenesis 15, 2131-2135.
32. Lorenzen, A., and Okey, A. B. (1991). Detection and characterization of Ah receptor in tissue and cells from human tonsils. Toxicol. Appl. Pharmacol. 107, 203-214.
33. Masten, S. A., and Shiverick, K. T. (1995). TCDD-inducible protein-DNA interactions in human B lymphocyte cell lines. Toxicologist 15, 64.
34. 2+-mediated endonuclease activation. Science 242, 256-258.
35. Morris, D. L., Jeong, H. G., Stevens, W. D., Chun, Y. J., and Karras, J. G. (1994). Serum modulation of the effects of TCDD on the in vitro antibody response and on enzyme induction in primary hepatocytes. Immunopharmacology 27, 93-105.
36. Newell, M. K., Haughn, L. J., Maroun, C. R., and Julius, M. H. (1990). Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen. Nature 347, 286-289.
37. Nicotera, P., McConkey, D. J., Dypbukt, J. M., Jones, D. P., and Orrenius, S. (1989). Ca2+-activated mechanisms in cell killing. Drug Metab. Rev. 20, 193-201.
38. Pietrangeli, C. E., Hayashi, S.-I., and Kincade, P. W. (1988). Stromal cell lines which support lymphocyte growth: Characterization, sensitivity to radiation and responsiveness to growth factors. Eur. J. Immunol. 18, 863-872.
39. Poland, A., Glover, E., and Bradfield, C. (1990). Characterization of polyclonal antibodies to the Ah receptor prepared by immunization with a synthetic peptide hapten. Mol. Pharmacol. 39, 20-26.
40. Rice, J. E., Hosted, T. J., Jr., and Lavoie, E. J. (1984). Fluoranthene and pyrene enhance benzo[a]pyrene-DNA adduct formation in vivo in mouse skin. Cancer Lett. 24, 327-333.
41. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989). Molecular Cloning, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
42. Silkworth, J. B., and Vecchi, A. (1985). Role of the Ah receptor in halogenated aromatic hydrocarbon immunotoxicity. Immunotoxicol. Immunopharmacol. 7, 263-275.
43. Silverstone, A. E., Frazier, D. E., Jr., and Gasiewicz, T. A. (1994). Alternate immune system targets for TCDD: Lymphocyte stem cells and extrathymic T-cell development. Exp. Clin. Immunogenet. 11, 94-101.
44. Singh, S. S., and Perdew, G. W. (1993). Alterations in the AhR level after staurosporine treatment. Arch. Biochem. Biophys. 305, 170-175.
45. Sterling, K., Raha, A., and Bresmck, E. (1994). Induction of CYP1A1 gene expression in mouse hepatoma cells by benzo[e]pyrene, a ligand of the 4S polycylic hydrocarbon-binding protein. Toxicol. Appl. Pharmacol. 128, 18-24.
46. Tomar, R. S., and Kerkvliet, N. I. (1991). Reduced T-helper cell function in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol. Lett. 57, 55-64.
47. Ucker, D. S., Meyers, J., and Obermiller, P. S. (1992). Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death. J. Immunol. 149, 1583-1592.
48. Vaca, C., Tornqvist, M., Rannug, U., Lindahl-Kiessling, K., Ahnstrom, G., and Ehrenberg, L. (1992). On the bioactivation and genotoxic action of fluoranthene. Arch. Toxicol. 66, 538-545.
49. Waither, W. I., Michaud, M., Harper, P. A., Okey, A. B., and Anderson, A. (1991). The Ah receptor, cytochrome P450IA1 mRNA induction, and aryl hydrocarbon hydroxylase in a human lymphoblastoid line. Biochem. Pharmacol. 41, 85-92.
50. Wang, J. S., and Busby, W. F., Jr. (1993). Induction of lung and liver tumors by fluoranthene in a preweanling CD-1 mouse bioassay. Carcinogenesis 14, 1871-1874.
51. White, K. L., Jr., Lysy, H. H., and Holsapple, M. P. (1985). Immunosuppression by polycyclic aromatic hydrocarbons: A structure-activity relationship in B6C3F1 and DBA/2 mice. Immunopharmacology 9, 155-164.
52. Whitlock, C. A., Robertson, D., and Witte, O. N. (1984). Murine B cell lymphopoiesis in long term culture. J. Immunol. Methods 67, 353-369.
53. Wojdani, A., Attarzadeh, M., Wode-Tsadik, G., and Alfred, L. J. (1984). Immunocytotoxicity effects of polycyclic aromatic hydrocarbons on mouse lymphocytes. Toxicology 31, 181-189.
54. blk kinase in signaling growth arrest and apoptosis. Immunol. Rev. 132, 162-186.