Effects of quorum-sensing on immunoglobulin G responses in a rat model of chronic lung infection with Pseudomonas aeruginosa

Microbes and Infection

Volumn 6, Issue 1, 2004, Pages 34-37

  Wu, Hong ^a   Song, Zhijun ^a   Givskov, Michael ^b   Høiby, Niels ^a  

^a Rigshospitalet   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Chronic lung infection; Immunoglobulin G; Pseudomonas aeruginosa; Quorum sensing; Rat model

Indexed keywords

IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ARTICLE; BACTERIUM MUTANT; IMMUNE RESPONSE; LUNG INFECTION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RAT; WILD TYPE;

PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 1642493663     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micinf.2003.10.006     Document Type: Article

References (34)

1. Hoiby N. Understanding bacterial biofilms in patients with cystic fibrosis: current and innovative approaches to potential therapies. J. Cystic Fibrosis. 1:2002;249-254.
2. Song Z., Kharazmi A., Wu H., Faber V., Moser C., Krogh H.K., Rygaard J., Hoiby N. Effects of ginseng treatment on neutrophil chemiluminescence and immunoglobulin G subclasses in a rat model of chronic Pseudomonas aeruginosa pneumonia. Clin. Diagn. Lab. Immunol. 5:1998;882-887.
3. Gambello M.J., Iglewski B.H. Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J. Bacteriol. 173:1991;3000-3009.
4. Ochsner U.A., Reiser J. Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA. 92:1995;6424-6428.
5. Passador L., Cook J.M., Gambello M.J., Rust L., Iglewski B.H. Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science. 260:1993;1127-1130.
6. Diggle S.P., Winzer K., Chhabra S.R., Worrall K.E., Camara M., Williams P. The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR. Mol. Microbiol. 50:2003;29-43.
7. McKnight S.L., Iglewski B.H., Pesci E.C. The Pseudomonas quinolone signal regulates rhl quorum sensing in Pseudomonas aeruginosa. J. Bacteriol. 182:2000;2702-2708.
8. Pearson J.P., Gray K.M., Passador L., Tucker K.D., Eberhard A., Iglewski B.H., Greenberg E.P. Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc. Natl. Acad. Sci. USA. 91:1994;197-201.
9. Pearson J.P., Passador L., Iglewski B.H., Greenberg E.P. A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA. 92:1995;1490-1494.
10. Davies D.G., Parsek M.R., Pearson J.P., Iglewski B.H., Costerton J.W., Greenberg E.P. The involvement of cell-to-cell signals in the development of a bacterial biofilm (see comments). Science. 280:1998;295-298.
11. Van Delden C., Iglewski B.H. Cell-to-cell signaling and Pseudomonas aeruginosa infections. Emerg. Infect. Dis. 4:1998;551-560.
12. Pearson J.P., Feldman M., Iglewski B.H., Prince A. Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection. Infect. Immun. 68:2000;4331-4334.
13. Wu H., Song Z., Givskov M., Doring G., Worlitzsch D., Mathee K., Rygaard J., Hoiby N. Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection. Microbiology. 147:2001;1105-1113.
14. Tang H.B., DiMango E., Bryan R., Gambello M., Iglewski B.H., Goldberg J.B., Prince A. Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection. Infect. Immun. 64:1996;37-43.
15. Telford G., Wheeler D., Williams P., Tomkins P.T., Appleby P., Sewell H., Stewart G.S., Bycroft B.W., Pritchard D.I. The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity. Infect. Immun. 66:1998;36-42.
16. Smith R.S., Harris S.G., Phipps R., Iglewski B. The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl) homoserine lactone contributes to virulence and induces inflammation in vivo. J. Bacteriol. 184:2002;1132-1139.
17. Pearson J.P., Pesci E.C., Iglewski B.H. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes. J. Bacteriol. 179:1997;5756-5767.
18. Johansen H.K., Espersen F., Cryz S.J. Jr, Hougen H.P., Fomsgaard A., Rygaard J., Hoiby N. Immunization with Pseudomonas aeruginosa vaccines and adjuvant can modulate the type of inflammatory response subsequent to infection. Infect. Immun. 62:1994;3146-3155.
19. Johansen H.K., Espersen F., Pedersen S.S., Hougen H.P., Rygaard J., Hoiby N. Chronic Pseudomonas aeruginosa lung infection in normal and athymic rats. APMIS. 101:1993;207-225.
20. Kharazmi A., Doring G., Hoiby N., Valerius N.H. Interaction of Pseudomonas aeruginosa alkaline protease and elastase with human polymorphonuclear leukocytes in vitro. Infect. Immun. 43:1984;161-165.
21. Kharazmi A., Eriksen H.O., Doring G., Goldstein W., Hoiby N. Effect of Pseudomonas aeruginosa proteases on human leukocyte phagocytosis and bactericidal activity. Acta Pathol. Microbiol. Immunol. Scand. C. 94:1986;175-179.
22. Doring G., Goldstein W., Roll A., Schiotz P.O., Hoiby N., Botzenhart K. Role of Pseudomonas aeruginosa exoenzymes in lung infections of patients with cystic fibrosis. Infect. Immun. 49:1985;557-562.
23. Moser C., Kjaergaard S., Pressler T., Kharazmi A., Koch C., Hoiby N. The immune response to chronic Pseudomonas aeruginosa lung infection in cystic fibrosis patients is predominantly of the Th2 type. APMIS. 108:2000;329-335.
24. Belardelli F. Role of interferons and other cytokines in the regulation of the immune response. APMIS. 103:1995;161-179.
25. Jankovic D., Liu Z., Gause W.C. Th1- and Th2-cell commitment during infectious disease: asymmetry in divergent pathways. Trends Immunol. 22:2001;450-457.
26. Neurath M.F., Finotto S., Glimcher L.H. The role of Th1/Th2 polarization in mucosal immunity. Nat. Med. 8:2002;567-573.
27. Mosmann T.R., Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today. 17:1996;138-146.
28. Doring G., Bellon G., Knight R. Immunology of cystic fibrosis. Hodson M.E., Geddes D.M. Cystic Fibrosis. 2000;109-140 Arnold, London.
29. Hoiby N., Giwercman B., Jensen T., Johansen H.K., Kronborg G., Pressler T., Kharazmi A. Immune response in cystic fibrosis - helpful or harmful? Scobar H., Baquero C.F., Suarez L. Clinical Ecology of Cystic Fibrosis. 1993;133-141 Exerpta Medica, Amsterdam.
30. Wu H., Song Z., Hentzer M., Andersen J.B., Heydorn A., Mathee K., Moser C., Eberl L., Molin S., Hoiby N., Givskov M. Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa. Microbiology. 146:2000;2481-2493.
31. Singh P.K., Schaefer A.L., Parsek M.R., Moninger T.O., Welsh M.J., Greenberg E.P. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature. 407:(6805):2000;762-764.
32. Hentzer M., Riedel K., Rasmussen T.B., Heydorn A., Andersen J.B., Parsek M.R., Rice S.A., Eberl L., Molin S., Hoiby N., Kjelleberg S., Givskov M. Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology. 148:2002;87-102.
33. Manefield M., Harris L., Rice S.A., de Nys R., Kjelleberg S. Inhibition of luminescence and virulence in the black tiger prawn (Penaeus monodon) pathogen Vibrio harveyi by intercellular signal antagonists. Appl. Environ. Microbiol. 66:2000;2079-2084.
34. Johansen H.K., Hoiby N., Pedersen S.S. Experimental immunization with Pseudomonas aeruginosa alginate induces IgA and IgG antibody responses. APMIS. 99:1991;1061-1068.