The immune response to chronic Pseudomonas aeruginosa lung infection in cystic fibrosis patients is predominantly of the Th2 type

APMIS

Volumn 108, Issue 5, 2000, Pages 329-335

  Moser, Claus ^a,b   Kjaergaard, Susanne ^a   Pressler, Tacjana ^a   Kharazmi, Arsalan ^a   Koch, Christian ^a   Høiby, Niels ^a  

^a Mental Health Center Glostrup   (Denmark)

^b University of Copenhagen   (Denmark)

Author keywords

Cystic fibrosis; Pseudomonas aeruginosa; Th1 Th2 response

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4;

ADULT; ANTIBODY RESPONSE; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CYSTIC FIBROSIS; CYTOKINE PRODUCTION; FEMALE; GRAM NEGATIVE INFECTION; HUMAN; IMMUNE RESPONSE; LUNG FUNCTION; LUNG INFECTION; MALE; PRIORITY JOURNAL; PROGNOSIS; TH2 CELL;

EID: 0033937232     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0463.2000.d01-64.x     Document Type: Article

References (27)

1. 1. Høiby N, Andersen V, Bendixen G. Pseudomonas aeruginosa infection in cystic fibrosis. Humoral and cellular immune responses against Pseudomonas aeruginosa. Acta path microbiol scand Sect C 1975;83:459-68.
2. 2. Høiby N. Pseudomonas aeruginosa infection in cystic fibrosis. Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of crossed immunoelectrophoresis. A survey. Acta path microbiol scand Sect C 1977;(Suppl 262):3-96.
3. 3. Colten HR. Airway inflammation in cystic fibrosis. N Engl J Med 1995;332:886-7.
4. 4. Sorensen RU, Waller RL, Klinger JD. Infection and immunity to Pseudomonas. Clin Rev Allergy 1991;9:47-74.
5. 5. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-57.
6. 6. Lucey DR, Clerici M, Shearer GM. Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin Microbiol Rev 1996;9:532-62.
7. 7. Heinzel FP, Sadick MD, Mutha SS, Locksley RM. Production of interferon γ, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc Natl Acad Sci 1991;88:7011-5.
8. 8. Kemp M, Theander TG, Kharazmi A. The contrasting roles of CD4+ cells in intracellular infections in humans: leishmaniasis as an example. Immunol Today 1996;17:13-6.
9. 9. Kemp M, Hey AS, Kurtzhals JAL, Christensen CBV, Gaafar A, Mustafa MD, et al. Dichotomy of the human T cell response to Leishmania antigens. I. Th1-like response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis. Clin Exp Immunol 1994;96:410-5.
10. 10. Kurtzhals JAL, Hey AS, Jardim A, Kemp M, Schaefer KU, Odera EO, et al. Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients. Clin Exp Immunol 1994;96:416-21.
11. 11. Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR, et al. Defining protective response to pathogens: cytokine profiles in leprosy lesions. Science 1991;254:277-9.
12. 12. van Voorhis WC, Barrett LK, Koelle DM, Nasio JM, Plummer FA, Lukehart SA. Primary and secondary syphilis lesions contain mRNA for Th1 cytokines. J Infect Dis 1996;173:495-8.
13. 13. Surcel HM, Troye-Blomberg M, Paulie S, Andersson G, Moreno C, Pasvol G, et al. Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens. Immunology 1994;81:171-6.
14. 14. Johansen HK, Hougen HP, Cryz Jr SJ, Rygaard J, Høiby N. Vaccination promotes Th1-like inflammation and survival in chronic Pseudomonas aeruginosa pneumonia in rats. Am J Respir Crit Care Med 1995;152:1337-46.
15. 15. Johansen HK, Hougen HP, Rygaard J, Høiby N. Interferon gamma (IFN-γ) treatment decreases the inflammatory response in chronic Pseudomonas aeruginosa pneumonia in rats. Clin Exp Immunol 1996;103:212-8.
16. 16. Moser C, Johansen HK, Song Z, Hougen HP, Rygaard J, Høiby N. Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice. APMIS 1997; 105:838-42.
17. 17. Padovan E, von-Greyers S, Pichler WJ, Weltzien HU. Antigen-dependent and -independent IFN-γ modulation by penicillins. J Immunol 1999; 162:1171-7.
18. 18. Riesbeck K, Sigvardsson M, Leanderson T, Forsgren A. Superinduction of cytokine gene transcription by ciprofloxacin. J Immunol 1994;153: 343-52.
19. 19. Polgar GE, Promadhat V. Pulmonary function testing in children: Techniques and standards. Philadelphia: WB. Saunders, 1971:88-107.
20. 20. Filip C, Fletcher G, Wulff JL, Earhart CF. Solubilisation of the cytoplasmic membrane of Escherichia coli by the ionic detergent sodium lauroyl sarcosinate. J Bacteriol 1973;115:717-22.
21. 21. Shand GH, Anwar H, Kadurugamuwa J, Brown MRW, Silverman SH, Melling J. In vivo evidence that bacteria in urinary tract infection grow under iron-restricted conditions. Infect Immun 1985;48:35-9.
22. 22. Kurtzhals JAL, Hansen MB, Hey AS, Poulsen LK. Measurement of antigen-dependent interleukin-4 production by human peripheral blood mononuclear cells. J Immunol Methods 1992; 156:239-45.
23. 23. Hjelt K, Hoejlyng N, Howitz P, Illum N, Munk E, Valerius NH, et al. The role of mycobacteria other than tuberculosis (MOTT) in patients with cystic fibrosis. Scand J Infect Dis 1994;26:569-76.
24. 1-antiprotease complex in cystic fibrosis: comparison with interstitial lung disease and evaluation of the effect of intravenously administered antibiotic therapy. Am Rev Respir Dis 1991;144:580-5.
25. 25. Regelmann WE, Elliot GR, Warwick WJ, Clawson CC. Reduction of sputum Pseudomonas aeruginosa density by antibiotics improves lung function in cystic fibrosis more than do bronchodilators and chest physiotherapy alone. Am Rev Respir Dis 1990;141:914-21.
26. 26. Hviid L, Kurtzhals JAL, Goka BQ, Oliver-Commey JO, Nkrumah FK, Theander TG. Rapid reemergence of T cells into peripheral circulation following treatment of severe and uncomplicated Plasmodium falciparum malaria. Infect Immun 1997;65:4090-3.
27. 27. Frederiksen B, Lanng S, Koch C, Høiby N. Improved survival in the Danish center-treated cystic fibrosis patients: results of aggressive treatment. Pediatr Pulmonol 1996;21:153-8.