In vivo IL-10 and TGF-β production by PBMC from long-term kidney transplant recipients with excellent graft function: A possible feedback mechanism participating in immunological stability

Clinical Transplantation

Volumn 18, Issue 2, 2004, Pages 174-178

  Alberú, Josefina ^a   Richaud Patin, Yvonne ^a   Vásquez Lavista, Luis Gabriel ^a   de Leo, Claudia ^a   Guzmán Rodríguez, Hugo ^a   Mancilla, Eduardo ^b   Correa Rotter, Ricardo ^a   Chew Wong, Alfredo ^a   Llorente, Luis ^a  

^a INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^b INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

Author keywords

IL 10; Kidney transplantation; Long term graft function; TGF

Indexed keywords

AZATHIOPRINE; CREATININE; INTERLEUKIN 10; PREDNISONE; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGE; AGED; ARTICLE; BLOOD CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE BLOOD LEVEL; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEEDBACK SYSTEM; FEMALE; FOLLOW UP; GRAFT SURVIVAL; HISTOCOMPATIBILITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VIVO STUDY; KIDNEY DISEASE; KIDNEY TRANSPLANTATION; LONG TERM CARE; MALE; MONONUCLEAR CELL; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEINURIA; RECIPIENT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SUPERNATANT;

ADULT; AGED; AZATHIOPRINE; CELLS, CULTURED; CROSS-SECTIONAL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-10; KIDNEY; KIDNEY TRANSPLANTATION; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PREDNISONE; TRANSFORMING GROWTH FACTOR BETA;

EID: 1642483692     PISSN: 09020063     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1399-0012.2003.00149.x     Document Type: Article

References (18)

1. Harber M, Sundstead A, Wraith D. The role of cytokines in immunological tolerance: Potential for therapy. Exp Rev Mol 2000: http:/Www.ermm.cbcu.cam.uk/00002143h.htm.
2. Spriewald B, Billing S, Wood K. Cytokines as mediators in immunologic tolerance. Curr Opin Org Trans 2001: 6: 7
3. Nickerson P, Steiger J, Zheng X et al. Manipulation of cytokine networks in transplantation. Transplantation 1997: 63: 489.
4. Wells A, Turka L. The role of apoptosis in induction and maintenance of tolerance. Curr Opin Org Trans 2001: 6: 1.
5. Mahzuz K, Bushell A, Wood K. Regulatory T cells in transplantation. Curr Opin Immunol 2002: 14: 584.
6. Yu X-Z, Carpenter P, Anaseti C. Advances in transplantation tolerance. Lancet 2001: 357: 1959.
7. Assereman C, Von Herrath M. About CD4+ CD25+ regulatory T cells. Autoimmunity Rev 2002: 1: 190.
8. VanBurskirk AM, Burlingham WJ, Jankowska-Gan E et al. Human allograft acceptance is assosiated with immune regulation. J Clin Invest 2000: 106: 145.
9. Ferguson TA, Green DR. T cells are just dying to accept grafts. Nat Med 1999: 5: 1231.
10. Groux H, Bigler M, Vries J, Roncarolo MC. Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells. J Immunol 1998: 160: 3188.
11. Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM. Macrophages that have ingested apoptotic cells in vitro inhibit proinflamatory cytokine production through autocrine/paracrine mechanism involving TGF-β, PGE2 and PAF. J Clin Invest 1998: 101: 890.
12. Alberu J, Richaud-Patin Y, Mancilla E et al. Effects of cyclosporine withdrawal on IL-10 production in kidney transplant recipients. Transplant Proc 2001: 33: 2024.
13. Maeda H, Shiraishi A. TGF-β contributes to the shift toward Th2-Type responses through direct and IL-10 mediated pathways in tumor-bearing mice. J Immunol 1996: 156: 73.
14. Sankaran D, Asderakis A, Ashraf S et al. Cytokine gene polimorfisms predict acute graft rejection following renal transplantation. Kidney Int 1999: 56: 281.
15. Levings MK, Sangregorio R, Roncarolo MG. Human CD25+CD4+ T regulatory cells suppress naïve and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001: 193: 1295.
16. Yamagiwa S, Gray JD, Hashimoto S, Horwitz DA. A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J Immunol 2001: 166: 7282.
17. Llorente L, Richaud-Patin Y, Wijdens J et al. Spontaneous production of interleukin - 10 by B lymphocytes and monocytes in systemic lupus erythematosus. Eur Cytokine Netw 1993: 4: 421.
18. Ayanlar Batuman O, Ferrero AP, Diaz A, Jimenez SA. Regulation of transforming growth factor-β1 gene by glucocorticoids in normal human T lymphocytes. J Clin Invest 1999: 88: 1574.