ICM0301s, new angiogenesis inhibitors from Aspergillus sp. F-1491. I. Taxonomy, fermentation, isolation and biological activities

Journal of Antibiotics

Volumn 57, Issue 2, 2004, Pages 97-103

  Kumagai, Hiroyuki ^b   Someno, Tetsuya ^b   Dobashi, Kazuyuki ^a   Isshiki, Kunio ^a   Ishizuka, Masaaki ^b   Ikeda, Daishiro ^b  

^a MERCIAN CORPORATION   (Japan)

^b INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; BASIC FIBROBLAST GROWTH FACTOR; FIBRIN; ICM 0301A; ICM 0301B; ICM 0301C; ICM 0301D; ICM 0301E; ICM 0301F; ICM 0301G; ICM 0301H; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTIMICROBIAL ACTIVITY; AORTA; ARTICLE; ASPERGILLUS; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DRUG ACTIVITY; DRUG ISOLATION; DRUG PURIFICATION; DRUG SCREENING; ENDOTHELIUM CELL; FEMALE; FERMENTATION MEDIUM; FUNGAL STRAIN; FUNGUS CULTURE; GEL; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SYMPTOMATOLOGY; TUMOR CELL; UMBILICAL VEIN;

ASPERGILLUS;

EID: 1642482976     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.57.97     Document Type: Article

References (21)

1. Folkman, J. & P. AW D'Amore: Blood vessel formation: what is its molecular basis? Cell 87(7): 1153-1155, 1996
2. Folkman, J. & Y. Shing: Angiogenesis. J. Biol. Chem. 267(16): 10931-10934, 1992
3. Folkman, J.: The role of angiogenesis in tumor growth. Semin Cancer Biol. 3(2): 65-71, 1992
4. Weidner, N.; P. R. Carroll, J. Flax, W. Blumenfeld & J. Folkman: Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am. J. Pathol. 143(2): 401-409, 1993
5. Giatromanolaki, A.; E. Sivridis, N. Athanassou, E. Zois, P. E. Thorpe, R. A. Brekken, K. C. Gatter, A. L. Harris, I. M. Koukourakis & M. I. Koukourakis: TAe angiogenic pathway "vascular endothelial growth factor/flk-1 (KDR)-receptor" In rheumatoid arthritis and osteoarthritis. J. Pathol. 194(1): 101-108, 2001
6. Hanahan, D.: Signaling vascular morphogenesis and maintenance. Science 277: 48-50, 1997
7. Risau, W: Mechanism of angiogenesis. Nature 386(17): 671-674, 1997
8. Yanase, T.; M. Tamura, K. Fujita, S. Kodama & K. Tanaka: Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo. Cancer Res. 53(11): 2566-2570, 1993
9. Asano, M.; A. Yukita & H. Suzuki: Wide spectrum of antitumor activity of a neutralizing monoclonal antibody to human vascular endothelial growth factor. Jpn. J. Cancer Res. 90(1): 93-100, 1999
10. Aonuma, M.; Y. Yoshitake, K. Nishikawa & N. G. Tanaka: Different antitumor activities of anti-bFGF neutralizing antibodies: heparin-binding domain provides an inefficient epitope for neutralization in vivo. Anticancer Res. 19(5B): 4039-4044, 1999
11. Brooks, P, C.; A. M. Montgomery, M. Rosenfeld, R. A. Reisfeld, T. Hu, G. Klier & D. A. Cheresh: Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 79(7): 1157-1164, 1994
12. Allman, R.; P. Cowburn & M. Mason: In vitro and in vivo effects of a cyclic peptide with affinity for the alpha(nu) beta3 integrin in human melanoma cells. Eur. J. Cancer 36(3): 410-422, 2000
13. Tille, J. C.; J. Wood, S. J. Mandriota, C. Schnell, S. Ferrari, J. Mestan, Z. Zhu, L. Witte & M. S. Pepper: Vascular endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF- and basic fibroblast growth factor-induced angiogenesis in vivo and in vitro. J. Pharmacol. Exp. Ther. 299(3): 1073-1085, 2001
14. Pitt, J. L: The genus Penicillium and its teleomorphic states Eupenicillium and Talaromyces. Academic Press, London, 1979
15. Carmichael, J. W.; W. B. Kendric, I. L. Conners & L. Sigler: Genera of Hyphomycetes. University of Alberta Press, Alberta, 1980
16. Kornerup, A. & J. H. Wanscher: Methuen handbook of color, 3rd ed., Eyre Methuen, London, 1978
17. Nicosia, R. F. & A. Ottinetti: Growth of microvessels in serum-free matrix culture of rat aorta: A quantitative assay of angiogenesis in vitro. Lab. Invest. 63: 115-122, 1990
18. Sin, N.; L. Meng, M. Q. Wang, J. J. Wen, W G. Bornmann & C. M. Crews: The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proc. Natl. Acad. Sci. 94(12): 6099-6103, 1997
19. Kobayashi, H.; R. Sunaga, K. Furihata, N. Morisaki & S. Iwasaki: Isolation and structures of an antifungal antibiotic, fusarielin A, and related compounds produced by a Fusarium sp. J. Antibiotics 48(1): 42-52, 1995
20. Zhu, W. H.; X. Guo, S. Villaschi & R. F. Nicosia: Regulation of vascular growth and regression by matrix metalloproteinases in the rat aorta model of angiogenesis. Lab. Invest. 80(4): 545-555, 2000
21. Ergun, S.; N. Kilic, J. H. Wurmbach, A. Ebrahimnejad, M. Fernando, S. Sevinc, E. Kilic, F. Chalajour, W. Fiedler, H. Lauke, K. Lamszus, P. Hammerer, J. Weil, H. Herbst & J. Folkman: Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes. Angiogenesis 4(3): 193-206, 2001