Expression and activity analyses of CTLA4 in peripheral blood lymphocytes in systemic lupus erythematosus patients

Lupus

Volumn 13, Issue 1, 2004, Pages 24-31

  Hirashima, Mika ^a   Fukazawa, T ^a   Abe, K ^a   Morita, Y ^a   Kusaoi, M ^a   Hashimoto, H ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CTLA4; Lupus nephritis; Systemic lupus erythematosus

Indexed keywords

B7 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ADOLESCENT; ADULT; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CHO CELL; CLINICAL ARTICLE; CLINICAL FEATURE; COCULTURE; CONTROLLED STUDY; DISEASE ACTIVITY; DNA SYNTHESIS; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

ADOLESCENT; ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; T-LYMPHOCYTES;

EID: 1642460103     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1191/0961203304lu488oa     Document Type: Article

References (32)

1. Karandikar NJ, Vanderlugt CL, Walunas TL, Miller SD, Bluestone JA. CTLA-4: a negative regulator of autoimmune disease. J Exp Med 1996; 184: 783.
2. Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone AJ, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995; 3: 541-547.
3. Carreno BM, Bennett F, Chau TA, Ling V, Luxenberg D, Jussif J et al. CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression. J Immunol 2000; 165: 1352-1356.
4. Lenschow DJ, Walunas TL, Bluestone JA. CD28/B7 system of T cell costimulation. Annu Rev Immunol 1996; 14: 233-258.
5. Nakaseko C, Miyatake S, Iida T, Hara S, Abe R, Ohno H et al. Cytotoxic T lymphocyte antigen 4 (CTLA4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosin motif in the cytoplasmic tail. J Exp Med 1999; 190: 765-774.
6. Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, et al. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 1995; 270: 985-988.
7. Perrin PJ, Maldonado JH, Davis TA, June CH, Racke MK. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. J Immunol 1996; 157: 1333.
8. Hurwitz AA, Sullivan TJ, Krummel MF, Sobel RA, Allison JP. Specific blockade of CTLA-4/B7 interactions results in exacerbated clinical and histological disease in an actively induced model of experimental allergic encephalomyelitis. J Neuroimmunol 1997; 73: 57.
9. Yamagata T, Hidaka Y, Guimaraes V, Soliman M, DeGroot LJ. CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population. J Clin Endocrinol Metab 1995; 80: 41.
10. Donner H, Rau H, Walfish PG, Braun J, Siegmaud T, Finke R et al. CTLA-4 alanine-17 confers genetic susceptibility to Graves' disease and to type I diabetes mellitus. J Clin Endocrinol Metab 1997; 82: 143.
11. Marron MP, Raffel LJ, Garchon HJ, Jacob CO, Serrano-Rios M, Martinez Larrad MT et al. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic group. Hum Mol Genet 1997; 6: 1275-1282.
12. Ligers A, Teleshova N, Masterman T, Huang WX, Hillert J. CTLA-4 gene expression is influenced by promoter and exon 1 polymorphisms. Genes Immun 2001; 2(3): 145-152.
13. Seidl C, Donner H, Fischer B, Usadel KH, Sefried E, Kaltwasser JP et al. CTLA4 codon 17 dimorphism in patients with rheumatoid arthritis. Tissue Antigens 1998; 51: 62-66.
14. Kotzin BL. Systemic lupus erythematosus. Cell 1996; 85: 303.
15. Cohen PL. T- and B-cell abnormalities in systemic lupus. J Invest Dermatol 1993; 100: 69s.
16. Dayal AK, Kammer GM. The T cell enigma in lupus. Arthritis Rheum 1996; 39: 23.
17. Tan EM, Cohen A, Fries JF, Masi AT, McShane DJ, Rothfield NF et al. The 1982 revised criteria for the classification of SLE. Arthritis Rheum 1982; 25: 1271-1277.
18. Bombardier C, Glandman DD, Urowitz MB, Caron D, Chang C. Derivation of the SLEDAI. Arthritis Rheum 1992; 35: 630-640.
19. Boulougouris G, McLeod JD, Patel YI, Ellwood CN, Walker LSK, Sansom DM. Positive and negative regulation of human T cell activation mediated by the CTLA4/CD28 ligand CD80. J Immunol 1998; 161: 3919-3924.
20. Lindsten T, Lee KP, Harris ES, Petryniak B, Craighead N, Reynolds PJ et al. Characterization of CTLA-4 structure and expression on human T cells. J Immunol 1993; 151: 3489-3499.
21. Lisley PS, Greene JL, Tan P, Bradshaw J, Ledbetter JA, Anasetti C et al. Coexpression of CTLA-4 and CD28 on activated T lymphocytes. J Exp Med 1992; 176: 1595-1604.
22. Alegre ML, Noel PJ, Eisfelder BJ, Chuang E, Clark MR, Reiner SL et al. Regulation of surface and intracellular expression of CTLA-4 on mouse T cells. J Immunol 1996; 157: 4762-4770.
23. Liu MF, Liu HS, Wang CR, Lei HY. Expression of CTLA-4 molecule in peripheral blood T lymphocytes from patients with systemic lupus erythematosus. J Clin Immunol 1998; 18: 392-398.
24. Issazadeh S, Navikas V, Schaub M, Sayegh M, Khoury S. Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo. J Immunol 1998; 161: 1104-1112.
25. Lafage-Pochitaloff M, Costello R, Couez D, Simonetti J, Mannoni P, Mawas C et al. HumanCD28 and CTLA-4 Ig superfamily genes are located on chromosome 2 at bands q33-q34. Immunogenetics 1990; 31: 198-201.
26. Moser KL, Neas BR, Salmon JE, Yu H, Gray-McGuire C, Asundi N et al. Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees. Proc Natl Acad Sci USA 1998; 95: 14869-14874.
27. Gaffney PM, Kearns GM, Shark KB, Ortmann WA, Selby SA, Malmgren ML et al. A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families. Proc Natl Acad Sci USA 1998; 95: 14875-14879.
28. Ahmed S, Ihara K, Kanematsu S, Nakashima H, Otsuka T, Tsuzaka K et al. Association of CTLA-4 but not CD28 gene polymorphisms with systemic lupus erythematosus in the Japanese population. Rheumatology 2001; 40: 662-667.
29. Lee KM, Chuang E, Griffin M et al. Molecular basis of T cell inactivation by CTLA-4. Science 1998; 282: 2263-2266.
30. Oaks MK, Hallett KM, Penwell RT, Stauber EC, Warren SJ, Tector AJ. A native soluble form of CTLA4. Cell Immunol 2000; 201: 144-153.
31. Liu MF, Wang CR, Chen PC, Fung LL. Increased expression of soluble cytotoxic T-lymphocyte-associated antigen-4 molecule in patients with systemic lupus erythematosus. Scan J Immunol 2003; 57: 568-572.
32. Finck Bk, Linsley PS, Wofsy D. Treatment of murine lupus with CTLA4Ig. Science 1994; 265: 1225.