Mechanism of feline immunodeficiency virus envelope glycoprotein-mediated fusion

Virology

Volumn 321, Issue 2, 2004, Pages 274-286

  Garg, Himanshu ^a   Fuller, Frederick J ^a   Tompkins, Wayne A F ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Feline immunodeficiency virus; Glycoprotein mediated fusion; Lentiviruses

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); ANTIINFECTIVE AGENT; CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; T 1971; TRYPTOPHAN; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DRUG INHIBITION; DRUG TARGETING; FELINE IMMUNODEFICIENCY VIRUS; HUMAN; HUMAN CELL; MEMBRANE FUSION; NONHUMAN; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; SYNCYTIUM; T LYMPHOCYTE; VIRUS ENVELOPE; VIRUS STRAIN;

AMINO ACID SEQUENCE; ANIMALS; CATS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; GIANT CELLS; HETEROCYCLIC COMPOUNDS; IMMUNODEFICIENCY VIRUS, FELINE; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CXCR4; SEQUENCE ALIGNMENT; TRYPTOPHAN; VIRAL FUSION PROTEINS;

FELIDAE; FELINE IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; PRIMATES; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 1642446592     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virol.2004.01.006     Document Type: Article

References (42)

1. Alimonti J.B., Ball T.B., Fowke K.R. Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS. J. Gen. Virol. 84:2003;1649-1661.
2. Carr C.M., Kim P.S. A spring-loaded mechanism for the conformational change of influenza hemagglutinin. Cell. 73:1993;823-832.
3. Chen S.S. Expression and processing of the human immunodeficiency virus type 1 envelope glycoprotein. Intervirology. 39:1996;242-248.
4. Choe H., Martin K.A., Farzan M., Sodroski J., Gerard N.P., Gerard C. Structural interactions between chemokine receptors, gp120 Env and CD4. Semin. Immunol. 10:1998;249-257.
5. De Parseval A., Elder J.H. Binding of recombinant feline immunodeficiency virus surface glycoprotein to feline cells: role of CXCR4, cell-surface heparans, and an unidentified non-CXCR4 receptor. J. Virol. 75:2001;4528-4539.
6. Egberink H.F., De Clercq E., Van Vliet A.L., Balzarini J., Bridger G.J., Henson G., Horzinek M.C., Schols D. Bicyclams, selective antagonists of the human chemokine receptor CXCR4, potently inhibit feline immunodeficiency virus replication. J. Virol. 73:1999;6346-6352.
7. English R.V., Johnson C.M., Gebhard D.H., Tompkins M.B. In vivo lymphocyte tropism of feline immunodeficiency virus. J. Virol. 67:1993;5175-5186.
8. Ferri K.F., Jacotot E., Geuskens M., Kroemer G. Apoptosis and karyogamy in syncytia induced by the HIV-1-envelope glycoprotein complex. Cell Death Differ. 7:2000;1137-1139.
9. Gallo S.A., Puri A., Blumenthal R. HIV-1 gp41 six-helix bundle formation occurs rapidly after the engagement of gp120 by CXCR4 in the HIV-1 Env-mediated fusion process. Biochemistry. 40:2001;12231-12236.
10. Gallo S.A., Finnegan C.M., Viard M., Raviv Y., Dimitrov A., Rawat S.S., Puri A., Durell S., Blumenthal R. The HIV Env-mediated fusion reaction. Biochim. Biophys. Acta. 1614:2003;36-50.
11. Giannecchini S., Di Fenza A., D'Ursi A.M., Matteucci D., Rovero P., Bendinelli M. Antiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein. J. Virol. 77:2003;3724-3733.
12. Hadzopoulou-Cladaras M., Felber B.K., Cladaras C., Athanassopoulos A., Tse A., Pavlakis G.N. The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region. J. Virol. 63:1989;1265-1274.
13. Hammarskjold M.L., Heimer J., Hammarskjold B., Sangwan I., Albert L., Rekosh D. Regulation of human immunodeficiency virus env expression by the rev gene product. J. Virol. 63:1989;1959-1966.
14. Hart T.K., Kirsh R., Ellens H., Sweet R.W., Lambert D.M., Petteway S.R. Jr., Leary J., Bugelski P.J. Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120. Proc. Natl. Acad. Sci. U.S.A. 88:1991;2189-2193.
15. Hohdatsu T., Hirabayashi H., Motokawa K., Koyama H. Comparative study of the cell tropism of feline immunodeficiency virus isolates of subtypes A, B and D classified on the basis of the env gene V3-V5 sequence. J. Gen. Virol. 77:1996;93-100.
16. Hosie M.J., Willett B.J., Dunsford T.H., Jarrett O., Neil J.C. A monoclonal antibody which blocks infection with feline immunodeficiency virus identifies a possible non-CD4 receptor. J. Virol. 67:1993;1667-1671.
17. Hosie M.J., Broere N., Hesselgesser J., Turner J.D., Hoxie J.A., Neil J.C., Willett B.J. Modulation of feline immunodeficiency virus infection by stromal cell-derived factor. J. Virol. 72:1998;2097-2104.
18. Jones P.L., Korte T., Blumenthal R. Conformational changes in cell surface HIV-1 envelope glycoproteins are triggered by cooperation between cell surface CD4 and co-receptors. J. Biol. Chem. 273:1998;404-409.
19. Kilby J.M., Hopkins S., Venetta T.M., DiMassimo B., Cloud G.A., Lee J.Y., Alldredge L., Hunter E., Lambert D., Bolognesi D., Matthews T., Johnson M.R., Nowak M.A., Shaw G.M., Saag M.S. Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry. Nat. Med. 4:1998;1302-1307.
20. Lawless M.K., Barney S., Guthrie K.I., Bucy T.B., Petteway S.R. Jr., Merutka G. HIV-1 membrane fusion mechanism: structural studies of the interactions between biologically-active peptides from gp41. Biochemistry. 35:1996;13697-13708.
21. Lu M., Blacklow S.C., Kim P.S. A trimeric structural domain of the HIV-1 transmembrane glycoprotein. Nat. Struct. Biol. 2:1995;1075-1082.
22. Malim M.H., Hauber J., Le S.Y., Maizel J.V., Cullen B.R. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature. 338:1989;254-257.
23. Medinas R.J., Lambert D.M., Tompkins W.A. C-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread. J. Virol. 76:2002;9079-9086.
24. Melikyan G.B., Markosyan R.M., Hemmati H., Delmedico M.K., Lambert D.M., Cohen F.S. Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion. Cell Biol. 151:2000;413-423.
25. Moir S., Poulin L. Expression of HIV env gene in a human T cell line for a rapid and quantifiable cell fusion assay. AIDS Res. Hum. Retrovir. 12:1996;811-820.
26. Moyle G. Stopping HIV fusion with enfuvirtide: the first step to extracellular HAART. J. Antimicrob. Chemother. 51:2003;213-217.
27. Pedersen N.C., Ho E.W., Brown M.L., Yamamoto J.K. Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. Science. 235:1987;790-793.
28. Phillips T.R., Lamont C., Konings D.A., Shacklett B.L., Hamson C.A., Luciw P.A., Elder J.H. Identification of the Rev transactivation and Rev-responsive elements of feline immunodeficiency virus. J. Virol. 66:1992;5464-5471.
29. Reeves J.D., Gallo S.A., Ahmad N., Miamidian J.L., Harvey P.E., Sharron M., Pohlmann S., Sfakianos J.N., Derdeyn C.A., Blumenthal R., Hunter E., Doms R.W. Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics. Proc. Natl. Acad. Sci. U.S.A. 99:2002;16249-16254.
30. Richardson J., Pancino G., Merat R., Leste-Lasserre T., Moraillon A., Schneider-Mergener J., Alizon M., Sonigo P., Heveker N. Shared usage of the chemokine receptor CXCR4 by primary and laboratory-adapted strains of feline immunodeficiency virus. J. Virol. 73:1999;3661-3671.
31. Saez-Cirion A., Nir S., Lorizate M., Agirre A., Cruz A., Perez-Gil J., Nieva J.L. Sphingomyelin and cholesterol promote HIV-1 gp41 pretransmembrane sequence surface aggregation and membrane restructuring. J. Biol. Chem. 277:2002;21776-21785.
32. Salzwedel K., Johnston P.B., Roberts S.J., Dubay J.W., Hunter E. Expression and characterization of glycophospholipid-anchored human immunodeficiency virus type 1 envelope glycoproteins. J. Virol. 67:1993;5279-5288.
33. Salzwedel K., West J.T., Hunter E.A. Conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity. J. Virol. 73:1999;2469-2480.
34. Suarez T., Nir S., Goni F.M., Saez-Cirion A., Nieva J.L. The pre-transmembrane region of the human immunodeficiency virus type-1 glycoprotein: a novel fusogenic sequence. FEBS Lett. 477:2000;145-149.
35. Verschoor E.J., Boven L.A., Blaak H., van Vliet A.L., Horzinek M.C., de Ronde A. A single mutation within the V3 envelope neutralization domain of feline immunodeficiency virus determines its tropism for CRFK cells. J. Virol. 69:1995;4752-4757.
36. Wild C.T., Shugars D.C., Greenwell T.K., McDanal C.B., Matthews T.J. Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection. Proc. Natl. Acad. Sci. U.S.A. 91:1994;9770-9774.
37. Wild C., Dubay J.W., Greenwell T., Baird T. Jr., Oas T.G., McDanal C., Hunter E., Matthews T. Propensity for a leucine zipper-like domain of human immunodeficiency virus type 1 gp41 to form oligomers correlates with a role in virus-induced fusion rather than assembly of the glycoprotein complex. Proc. Natl. Acad. Sci. U.S.A. 91:1994;12676-12680.
38. Willett B.J., Picard L., Hosie M.J., Turner J.D., Adema K., Clapham P.R. Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses. J. Virol. 71:1997;6407-6415.
39. Willett B.J., Adema K., Heveker N., Brelot A., Picard L., Alizon M., Turner J.D., Hoxie J.A., Peiper S., Neil J.C., Hosie M.J. The second extracellular loop of CXCR4 determines its function as a receptor for feline immunodeficiency virus. J. Virol. 72:1998;6475-6481.
40. Willett B.J., Cannon C.A., Hosie M.J. Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus. J. Virol. 76:2002;9242-9252.
41. Wyatt R., Sodroski J. The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens. Science. 280:1998;1884-1888.
42. Yang J.S., English R.V., Ritchey J.W., Davidson M.G., Wasmoen T., Levy J.K., Gebhard D.H., Tompkins M.B., Tompkins W.A. Molecularly cloned feline immunodeficiency virus NCSU1 JSY3 induces immunodeficiency in specific-pathogen-free cats. J. Virol. 70:1996;3011-3017.