Short-term oral toxicity of homoyessotoxins, yessotoxin and okadaic acid in mice

Toxicon

Volumn 43, Issue 4, 2004, Pages 439-445

  Tubaro, A ^a   Sosa, S ^a   Altinier, G ^a   Soranzo, M R ^a   Satake, M ^b   Della Loggia, R ^a   Yasumoto, T ^c  

^a UNIVERSITY OF TRIESTE   (Italy)

^b TOHOKU UNIVERSITY   (Japan)

^c JAPAN FOOD RESEARCH LABORATORIES   (Japan)

Author keywords

45 Hydroxy homoyessotoxin; Homoyessotoxin; Mice; Okadaic acid; Short term oral toxicity; Yessotoxin

Indexed keywords

45 HYDROXYHOMOYESSOTOXIN; AMINOTRANSFERASE; FISH VENOM; HOMOYESSOTOXIN; LACTATE DEHYDROGENASE; OKADAIC ACID; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; YESSOTOXIN;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; APPETITE; ARTICLE; ATROPHY; AUTOPSY; BODY WEIGHT; CAPILLARY; CELL NUCLEUS; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DEATH; DIARRHEA; ELECTRON MICROSCOPY; ENZYME BLOOD LEVEL; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; EXPOSURE; FOOD INTAKE; FORESTOMACH; HEART; HEART INJURY; HEART MUSCLE CELL; HISTOCHEMISTRY; HISTOPATHOLOGY; HYPERPLASIA; LACTATE DEHYDROGENASE BLOOD LEVEL; LETHALITY; LEUKOCYTE; LIVER; LYMPHOID ORGAN; MITOCHONDRION; MORTALITY; MOUSE; NONHUMAN; ORGAN WEIGHT; PANCREAS; PATHOLOGY; PRIORITY JOURNAL; SHELLFISH; STOMACH ULCER; SYMPTOM; TOXICITY; TRANSMISSION ELECTRON MICROSCOPY; WEIGHT REDUCTION;

ACUTE TOXICITY TESTS; ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; BLOOD CHEMICAL ANALYSIS; BODY CONSTITUTION; EATING; ETHERS, CYCLIC; FEMALE; HISTOCYTOCHEMISTRY; IN SITU NICK-END LABELING; L-LACTATE DEHYDROGENASE; LEUKOCYTES; MICE; MICROSCOPY, ELECTRON; MOLLUSK VENOMS; MYOCARDIUM; OKADAIC ACID; OXOCINS; STOMACH; TRANSAMINASES;

EID: 1642421706     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2004.02.015     Document Type: Article

References (26)

1. Alfonso A., de la Rosa L., Vieytes M.R., Yasumoto T., Botana L.M. Yessotoxin, a novel phycotoxin, activates phosphodiesterase activity. Effect of yessotoxin on cAMP levels in human lymphocytes. Biochem. Pharmacol. 65:2003;193-208.
2. Aune T., Sorby R., Yasumoto T., Ramstad H., Landsverk T. Comparison of oral and intraperitoneal toxicity of yessotoxin towards mice. Toxicon. 40:2002;77-82.
3. CEE. Commission decision of 15 March 2002. Official J Eur Comun. 2002;. 16.3.2002.
4. Draisci R., Lucentini L., Mascioni A. Pectenotoxins and yessotoxins: chemistry, toxicology, pharmacology, and analysis. Botana L.M. Seafood and Freshwater Toxins. Pharmacology, Physiology and Detection. 2000;289-324 Marcel Dekker, New York.
5. Inoue M., Hirama M., Satake M., Sugiyama K., Yasumoto T. Inhibition of brevetoxin binding to the voltage-gated sodium channel by gambierol and gambieric acid-A. Toxicon. 41:2003;469-474.
6. Ito E., Terao K. Injury and recovery process of intestine caused by okadaic acid and related compounds. Nat. Toxins. 2:1994;371-377.
7. Ito E., Satake M., Ofuji K., Kurita N., McMahon T., James K., Yasumoto T. Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland. Toxicon. 38:2000;917-930.
8. Ito E., Yasumoto T., Takai A., Imanishi S., Harada K. Investigation of the distribution and excretion of okadaic acid in mice using immunostaining method. Toxicon. 40:2002;159-165.
9. Kang Y.J. New understanding in cardiotoxicity. Curr. Opin. Drug Discov. Dev. 6:2003;110-116.
10. Leira F., Alvarez C., Vieites J.M., Vieytes M.R., Botana L.M. Characterization of distinct apoptotic changes induced by okadaic acid and yessotoxin in the BE(2)-M17 neuroblastoma cell line. Toxicol. In Vitro. 16:2002;23-31.
11. Lockwood W.R. A reliable and easily sectioned epoxy embedding medium. Anat. Res. 150:1964;129-140.
12. Malaguti C., Ciminiello P., Fattorusso E., Rossini G.P. Caspase activation and death induced by yessotoxin in HeLa cells. Toxicol. In Vitro. 16:2002;357-363.
13. Mattei C., Molgo J., Legrand A.M., Benoit E. Ciguatoxins and brevetoxins: dissection of the neurobiological actions. J. Soc. Biol. 193:1999;329-344.
14. Murata M., Kumagai M., Lee J.-S., Yasumoto T. Isolation and structure of yessotoxin, a novel polyether compound implicated in diarrhetic shellfish poisoning. Tetrahedron Lett. 28:1987;5869-5872.
15. Ogino H., Kumagai M., Yasumoto T. Toxicologic evaluation of yessotoxin. Nat. Toxins. 5:1997;255-259.
16. de la Rosa L., Alfonso A., Vilariño N., Vieytes M.R., Botana L.M. Modulation of cytosolic calcium levels of human lymphocytes by yessotoxin, a novel marine phycotoxin. Biochem. Pharmacol. 61:2001;827-833.
17. Satake M., Tubaro A., Lee J.-S., Yasumoto T. Two new analogs of yessotoxin, homoyessotoxin and 45-hydroxyhomoyessotoxin, isolated from mussels of the Adriatic Sea. Nat. Toxins. 5:1997;107-110.
18. Terao K., Ito E., Yanagi T., Yasumoto T. Histopathological studies on experimental marine toxin poisoning. 5. The effects in mice of yessotoxin isolated from Patinopecten yessoensis and of a desulfated derivative. Toxicon. 28:1990;1095-1104.
19. Terao K., Ito E., Oarada M., Ishibashi Y., Legrand A.-M., Yasumoto T. Light and electron microscopic studies of pathologic changes induced in mice by ciguatoxin poisoning. Toxicon. 29:1991;633-643.
20. Terao K., Ito E., Yasumoto T. Light and electron microscopic studies of the murine heart after repeated administrations of ciguatoxin or ciguatoxin-4c. Nat. Toxins. 1:1992;19-26.
21. Terao K., Ito E., Ohkusu M., Yasumoto T. A comparative study of the effects of DSP-toxins on mice and rats. Smayda T.J., Shimizu Y. Toxic Phytoplankton Blooms in the Sea. 1993;581-586 Elsevier, Amsterdam.
22. Tubaro A., Sidari L., Della Loggia R., Yasumoto T. Occurrence of homoyessotoxin in phytoplankton and mussels from Northern Adriatic Sea. Reguera B., Blanco J., Fernández M.L., Wyatt T. Harmful Algae. 1998;470-472 Xunta de Galicia and Intergovernmental Oceanographic Commission of UNESCO, Grafisant, Santiago de Compostela.
23. Tubaro A., Sosa S., Carbonatto M., Altinier G., Vita F., Melato M., Satake M., Yasumoto T. Oral and intraperitoneal acute toxicity studies of yessotoxin and homoyessotoxins in mice. Toxicon. 41:2003;783-792.
24. Venable J.H., Coggeshall R. A simplified lead citrate stain for use in electron microscopy. J. Cell. Biol. 25:1965;401-408.
25. Yasumoto T., Murata M. Marine toxins. Chem. Rev. 93:1993;1897-1909.
26. Yasumoto T., Takizawa A. Fluorometric measurement of yessotoxins in shellfish by high-pressure liquid chromatography. Biosci. Biotech. Biochem. 61:1997;1775-1777.