The New York High-Risk Project: Prevalence and comorbidity of Axis I disorders in offspring of schizophrenic parents at 25-year follow-up

Archives of General Psychiatry

Volumn 54, Issue 12, 1997, Pages 1096-1102

  Erlenmeyer Kimling, L ^a,b   Adamo, Ulla Hilldoff ^a   Rock, Donald ^d   Roberts, Simone A ^a   Bassett, Anne S ^e   Squires Wheeler, Elisabeth ^a,b   Cornblatt, Barbara A ^c   Endicott, Jean ^a,b   Pape, Sky ^a   Gottesman, Irving I ^f  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Columbia University ^*  (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d EDUCATIONAL TESTING SERVICE   (United States)

^e UNIVERSITY OF TORONTO   (Canada)

^f UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AFFECTIVE NEUROSIS; ARTICLE; FEMALE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PREVALENCE; PSYCHIATRIC DIAGNOSIS; SCHIZOPHRENIA; SUBSTANCE ABUSE; UNITED STATES; URBAN POPULATION;

EID: 15644377772     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.1997.01830240052008     Document Type: Article

References (45)

1. Zerbin-Rüdin E. Endogene Psychosen: Schizophrenien, in: Becker PE, ed. Human- genetik. Stuttgart, Germany: Georg Thieme Verlag; 1967;2:446-513.
2. Gottesman II, Shields J. Schizophrenia: The Epigenetic Puzzle. New York, NY: Cambridge University Press; 1982.
3. Gottesman II, McGuffin P, Farmer AE. Clinical genetics as clues to the 'real' genetics of schizophrenia (a decade of modest gains while playing for time). Schizophr Bull. 1987;13:23-47.
4. Baron M, Gruen R, Asnis L, Kane J. Schizoaffective illness, schizophrenia and affective disorders: morbidity risk and genetic transmission. Acta Psychiatr Scand. 1982;65:253-262.
5. Maier W, Lichtermann D, Minges J, Hallmayer J, Heun R, Benkert O, Levinson DF. Continuity and discontinuity of affective disorders and schizophrenia: results of a controlled family study. Arch Gen Psychiatry. 1993;50:871-883.
6. Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D. The Roscommon Family Study, I: methods, diagnosis of probands, and risk of schizophrenia in relatives. Arch Gen Psychiatry. 1993;50:527-540.
7. Kety SS, Wender PH, Jacobsen B, Ingraham LJ, Jansson L, Faber B, Kinney DK. Mental illness in the biological and adoptive relatives of schizophrenic adoptees: replication of the Copenhagen Study in the rest of Denmark. Arch Gen Psychiatry. 1994;51:442-455.
8. Maj M, Starace F, Pirozzi R. A family study of DSM-III-R schizoaffective disorder, depressive type, compared with schizophrenia and psychotic and nonpsychotic major depression. Am J Psychiatry. 1991;148:612-616.
9. Onstand S, Skre I, Edvardsen J, Torgersen S, Kringlen E. Mental disorders in firstdegree relatives of schizophrenics. Acta Psychiatr Scand Suppl. 1991;83:463-467.
10. Taylor MA, Berenbaum SA, Jampala VC, Cloninger CR. Are schizophrenia and affective disorder related? preliminary data from a family study. Am J Psychiatry. 1993;150:278-285.
11. Tsuang MT, Winokur G, Crowe RR. Morbidity risks of schizophrenia and affective disorders among first-degree relatives of patients with schizophrenia, mania, depression, and surgical conditions. Br J Psychiatry. 1980;137:497-504.
12. Gershon ES, DeLisi LE, Hamovit J, Nurnberger JL Jr, Maxwell ME, Schreiber J, Dauphinais D, Dingman CW II, Guroff JJ. A controlled family study of chronic psychoses. Arch Gen Psychiatry. 1988;45:328-336.
13. Kendler KS, Gruenberg AM, Tsuang MT. Psychiatric illness in the first-degree relatives of schizophrenic and surical control patients: a family study using DSM- III criteria. Arch Gen Psychiatry. 1985;42:770-779.
14. Maier W, Lichtermann D, Minges J, Heun R, Hallmeier J, Benkert O. Schizoaffective disorder and affective disorder with mood-incongruenl psychotic features: keep separate or combine? evidence from a family study. Am J Psychiatry. 1992;49:1666-1673.
15. Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D. The Roscommon Family Study, II: the risk of nonschizophrenic, nonaffective psychoses in relatives. Arch Gen Psychiatry. 1993;50:645-652.
16. Rüdin E. Zur Vererbung und Neuentstehung der Dementia Praecox, New York, NY: Springer-Verlag NY Inc; 1916.
17. Shields J, Heston LL, Gottesman II. Schizophrenia and the schizoid: the problem for genetic analysis. In: Fieve RR, Rosenthal D, Brill H, eds. Genetic Research in Psychiatry. Baltimore, Md: Johns Hopkins University Press; 1975:167-197.
18. Merikangas KR. Comorbidity for anxiety and depression: review of family arid genetic studies. In: Maser JD, Cloniger CR, eds. Comorbidity of Mood and Anxiety Disorders. Washington, DC: American Psychiatric Press, Inc. 1990:331-348.
19. Erlenmeyer-Kimling L, Squires-Wheeler E, Adamo UH, Bassett AS, Cornblatt BA, Kestenbaum CJ, Rock D, Roberts SA, Gottesman II. The New York High-Risk Project: psychoses and cluster A personality disorders in offspring of schizophrenic parents at 23 years of follow-up. Arch Gen Psychiatry. 1995;52:857-865.
20. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised. Washington, DC: American Psychiatric Association; 1987.
21. Spitzer RL, Endicott J. Schedule for Affective Disorders and Schizophrenia- Lifetime Version (SADS-L). 3rd ed. New York: Biometrics Unit, New York State Psychiatric Institute; 1978.
22. Spitzer RL, Endicott J, Robins E. Research Diagnostic Criteria (ROC) for a Selected Group of Functional Disorders. 3rd ed. New York: Biometrics Unit, New York State Psychiatric Institute; 1978.
23. Life tables and survivor functions. In: Dixon WJ, ed. BMDP Statistical Software Manual. Berkeley: University of California Press; 1992;2:800.
24. Logistic regression. In: SPSS Reference Guide. Chicago, III: SPSS Inc; 1990: 312-322.
25. Parnas J, Cannon TD, Jacobsen B, Schulsinger H, Schulsinger F, Mednick SA. Lifetime DSM-III-R diagnostic outcomes in the offspring of schizophrenic mothers. Arch Gen Psychiatry. 1993;50:707-714.
26. Ingraham LK, Kugelmass S, Frenkel E, Nathan M, Mirsky AF. Twenty-five year follow-up of the Israeli High-Risk Study: current and lifetime psychopathology. Schizophr Bull. 1995;21:183-192.
27. Gottesman II. Schizophrenia Genesis: The Origins of Madness. New York, NY: WH Freeman & Co; 1991.
28. Scharfetter C, Nusperli M. The group of schizophrenias, schizoaffective psychoses, and affective disorders. Schizophr Bull. 1980;6:586-591.
29. Rice JP, Reich T, Andreasen NC, Endicott J, Van Eerdewegh M, Fishman R, Hirschfeld RM, Klerman GL. The familial transmission of bipolar illness. Arch Gen Psychiatry. 1987;44:441-447.
30. Andreasen NC, Rice J, Endicott J, Coryell W, Grove WM, Reich T. Familial rates of affective disorder: a report from the National Institute of Mental Health Collaborative Study. Arch Gen Psychiatry. 1987;44:461-469.
31. Maier W, Hallmayer J, Minges J, Lichterman D. Affective and schizoaffective disorders: similarities and differences. In: Marneros A, Tsuang MT, eds. Morbid Risks in Relatives of Affective, Schizoaffective and Schizophrenia Patients: Results of a Family Study. New York, NY: Springer-Verlag NY Inc; 1990:201-207.
32. Angst J, Felder W, Lohmeyer B. Are schizoaffective psychoses heterogeneous? results of a genetic investigation, II. J Affect Disord. 1979;1:155-165.
33. Angst J, Felder W, Lohmeyer B. Schizoaffective disorders: results of a genetic investigation, I. J Affect Disord. 1979;1:139-153.
34. Propping P. Genetic relationship between the psychoses: implications for genetic modeling. In: Marneros A, Tsuang MT, eds. Affective and Schizoaffective Disorders. New York, NY: Spinger-Verlag NY Inc; 1990:195-200.
35. Bertelsen A, Gottesman II. Schizoaffective psychoses: genetical clues to classification. Am J Med Genet Neuropsychol Genet. 1996;60:7-11.
36. Kendler KS, McGuire M, Gruenberg AM, Walsh D. Examining the validity of DSM- III-R schizoaffective disorder and its putative subtypes in the Roscommon Family Study. Am J Psychiatry. 1995;152:755-764.
37. Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D. The Roscommon Family Study, IV: affective illness, anxiety disorders, and alcoholism in relatives. Arch Gen Psychiatry. 1993;50:952-960.
38. Winokur G, Coryell W, Endicott J, Akiskal H, Keller M, Maser JD, Warshaw M. Familial depression versus depression identified in a control group: are they the same? Psychol Med. 1995;25:797-806.
39. Weissman MM. Evidence for comorbidity of anxiety and depression: family and genetic studies of children. In: Maser JD, Cloniger CR, eds. Comorbidity of Mood and Anxiety Disorders. Washington, DC: American Psychiatric Press, Inc; 1990:349-365.
40. Weissman MM, Wickramaratne P, Adams PB, Lish JD, Horwath E, Charney D, Woods SW, Leeman E, Frosch E. The relationship between panic disorder and major depression. Arch Gen Psychiatry. 1993;50:767-780.
41. Wickramaratne PJ, Weissman MM. Using family studies to understand comorbidity. Eur Arch Psychiatry Neurosci. 1993;243:150-157.
42. Erlenmeyer-Kimling L, Cornblatt BA, Bassett AS, Moldin SO, Hilldoff Adamo U, Roberts S. High risk children in adolescence and young adulthood: course of global adjustment. In: Robins L, Rutter M, eds. Straight and Devious Pathways From Childhood to Adulthood. New York, NY: Cambridge University Press; 1990:351-364.
43. Silverton R, Bassett AS. The multidimensional global assessment of functioning scales. Presented at the Symposium on the New York High-Risk Project: 22nd year clinical follow-up, 41st annuat meeting of the American Academy of Child and Adolescent Psychiatry; October 29, 1994; New York, NY.
44. Faraone SV, Tsuang MT. Measuring diagnostic accuracy in the absence of a 'gold standard'. Am J Psychiatry. 1994;151:650-657.
45. Erlenmeyer-Kimling L, Janal M, Rock D, Roberts S, Cornblatt B. The New York High-Risk Project: predicting schizophrenia-related psychoses. Poster presented at the 35th annual meeting of the American College of Neuropsychopharmacology; December 9, 1996; San Juan, Puerto Rico.