KR-31378 protects neurons from ischemia-reperfusion brain injury by attenuating lipid peroxidation and glutathione loss

European Journal of Pharmacology

Volumn 487, Issue 1-3, 2004, Pages 81-91

  Kim, Sun Ok ^a   Cho, In Sun ^a   Gu, Hee Kyoung ^a   Lee, Dong Ha ^a   Lim, Hong ^a   Yoo, Sung Eun ^b  

^a Dongbu Hannong Chemical Co   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Antioxidant; Brain ischemia; K+ channel opener; KR 31378; Neuroprotection; Oxidative neuronal injury

Indexed keywords

4 (4 CHLOROPHENYL) N (1H IMIDAZOL 2 YLMETHYL)DIMETHYL 2H 1 BENZOPYRAN 6 CARBONITRILE; 5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE; CATALASE; DIAZOXIDE; ENZYME; FERROUS SULFATE; GLIBENCLAMIDE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GUANIDINE DERIVATIVE; KR 31378; LIPID; N (4 CHLOROPHENYL) N' CYANO N'' (6 CYANO 3,4 DIHYDRO 3 HYDROXY 2,2 DIMETHYL 2H 1 BENZOPYRAN 4 YL)GUANIDINE; N'' CYANO N (6 AMINO 3,4 DIHYDRO 3 HYDROXY 2 METHYL 2 DIMETHOXYMETHYL 2H BENZOPYRAN 4 YL) N' BENZYLGUANIDINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN EDEMA; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN NERVE CELL; CELL DEATH; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MODEL; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVITY; FETUS; HEMISPHERE; IC 50; LIPID PEROXIDATION; MALE; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; TIME; TISSUE CULTURE;

ANIMALS; ANTIOXIDANTS; ASTROCYTES; BRAIN EDEMA; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; FREE RADICALS; GLUTATHIONE; GUANIDINES; INFARCTION, MIDDLE CEREBRAL ARTERY; IRON; LIPID PEROXIDATION; MALE; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; POTASSIUM CHANNELS; PYRANS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 1642397398     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2003.12.037     Document Type: Article

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