Prevention of lipopolysaccharide-induced apoptosis by (2S,3S,4R)-N″-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2- dimethoxymethyl-2H-benzopyran-4-yl)-N′-benzylguanidine, a benzopyran analog, in endothelial cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 2, 2002, Pages 535-542

  Kim, Ki Young ^a   Kim, Byeong Gee ^b   Kim, Sun Ok ^c   Yoo, Sung Eun ^d   Kwak, Yong Geun ^e   Chae, Soo Wan ^e   Hong, Ki Whan ^a  

^a Pusan National University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

^c Dongbu Hannong Chemical Co   (South Korea)

^d Korea Research Institute of Chemical Technology   (South Korea)

^e Chonbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; BENZOPYRAN DERIVATIVE; CYTOCHROME C OXIDASE; DNA FRAGMENT; KR 31378; KR 31612; LIPOPOLYSACCHARIDE; N'' CYANO N (6 ACETYLAMINO 3,4 DIHYDRO 3 HYDROXY 2 METHYL 2 DIMETHOXYMETHYL 2H BENZOPYRAN 4 YL) N' BENZYLGUANIDINE; N'' CYANO N (6 AMINO 3,4 DIHYDRO 3 HYDROXY 2 METHYL 2 DIMETHOXYMETHYL 2H BENZOPYRAN 4 YL) N' BENZYLGUANIDINE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG MECHANISM; ENDOTHELIUM CELL; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCAVENGING SYSTEM; UMBILICAL VEIN;

ALPHA-TOCOPHEROL; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROME C GROUP; DNA FRAGMENTATION; ENDOTHELIUM, VASCULAR; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION; GENES, BCL-2; HUMANS; HYDROGEN PEROXIDE; LIPOPOLYSACCHARIDES; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036151714     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.2.535     Document Type: Article

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