Effects of hyperglycemia on hepatic gluconeogenic flux during glycogen phosphorylase inhibition in the conscious dog

American Journal of Physiology - Endocrinology and Metabolism

Volumn 286, Issue 4 49-4, 2004, Pages

  Edgerton, Dale S ^a   Cardin, Sylvain ^a   Neal, Doss ^a   Farmer, Ben ^a   Lautz, Margaret ^a   Pan, Catherine ^a   Cherrington, Alan D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gluconeogenesis; Glycogenolysis; Hepatic glucose production; Hyperinsulinemia

Indexed keywords

ENZYME INHIBITOR; FATTY ACID; GLUCAGON; GLUCOSE 6 PHOSPHATE; GLYCOGEN PHOSPHORYLASE; GLYCOGEN PHOSPHORYLASE INHIBITOR; INSULIN; LACTIC ACID; SOMATOSTATIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; ENZYME INHIBITION; FATTY ACID TRANSPORT; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; GLYCOGENOLYSIS; GLYCOLYSIS; HYPERGLYCEMIA; HYPERINSULINEMIA; MALE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACIDS; ANIMALS; DIHYDROPYRIDINES; DOGS; ENZYME INHIBITORS; FEMALE; FRUCTOSEPHOSPHATES; FURANS; GLUCAGON; GLUCONEOGENESIS; GLUCOSE; GLUCOSE-6-PHOSPHATE; GLYCOGEN PHOSPHORYLASE; HYPERGLYCEMIA; INSULIN; LACTIC ACID; LIVER; MALE;

EID: 1642395095     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00211.2003     Document Type: Article

References (48)

1. Aiston S, Hampson L, Gomez-Foix AM, Guinovart JJ, and Agius L. Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis. J Biol Chem 276: 23858-23866, 2001.
2. Bahl JJ, Matsuda M, DeFronzo RA, and Bressler R. In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase. Biochem Pharmacol 53: 67-74, 1997.
3. Bergans N, Stalmans W, Goldmann S, and Vanstapel F. Molecular mode of inhibition of glycogenolysis in rat liver by the dihydropyridine derivative, BAY R3401: inhibition and inactivation of glycogen phosphorylase by an activated metabolite. Diabetes 49: 1419-1426, 2000.
4. Cherrington AD, Stevenson RW, Steiner KE, Davis MA, Myers SR, Adkins BA, Abumrad NN, and Williams PE. Insulin, glucagon, and glucose as regulators of hepatic glucose uptake and production in vivo. Diabetes Metab Rev 3: 307-332, 1987.
5. Chiasson JL, Liljenquist JE, Finger FE, and Lacy WW. Differential sensitivity of glycogenolysis and gluconeogenesis to insulin infusions in dogs. Diabetes 25: 283-291, 1976.
6. Claus TH, El-Maghrabi MR, Regen DM, Stewart HB, McGrane M, Kountz PD, Nyfeler F, Pilkis J, and Pilkis SJ. The role of fructose 2,6-bisphosphate in the regulation of carbohydrate metabolism. Curr Top Cell Regul 23: 57-86, 1984.
7. DeFronzo RA and Ferrannini E. Regulation of hepatic glucose metabolism in humans. Diabetes Metab Rev 3: 415-459, 1987.
8. Dobbins RL, Davis SN, Neal DW, Cobelli C, and Cherrington AD. Pulsatility does not alter the response to a physiological increment in glucagon in the conscious dog. Am J Physiol Endocrinol Metab 266: E467-E478, 1994.
9. Edgerton DS, Cardin S, Emshwiller M, Neal D, Chandramouli V, Schumann WC, Landau BR, Rossetti L, and Cherrington AD. Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism. Diabetes 50: 1872-1882, 2001.
10. Edgerton DS, Cardin S, Pan C, Neal D, Farmer B, Converse M, and Cherrington AD. Effects of insulin deficiency or excess on hepatic gluconeogenic flux during glycogenolytic inhibition in the conscious dog. Diabetes 51: 3151-3162, 2002.
11. Friedmann B, Goodman EH Jr, and Weinhouse S. Effects of insulin and fatty acids on gluconeogenesis in the rat. J Biol Chem 242: 3620-3627, 1967.
12. Gerich JE. Control of glycaemia. Baillieres Clin Endocrinol Metab 7: 551-586, 1993.
13. Goldstein RE, Rossetti L, Palmer BA, Liu R, Massillon D, Scott M, Neal D, Williams P, Peeler B, and Cherrington AD. Effects of fasting and glucocorticoids on hepatic gluconeogenesis assessed using two independent methods in vivo. Am J Physiol Endocrinol Metab 283: E946-E957, 2002.
14. Hamilton KS, Gibbons FK, Bracy DP, Lacy DB, Cherrington AD, and Wasserman DH. Effect of prior exercise on the partitioning of an intestinal glucose load between splanchnic bed and skeletal muscle. J Clin Invest 98: 125-135, 1996.
15. Hellerstein MK, Neese RA, Schwarz JM, Turner S, Faix D, and Wu K. Altered fluxes responsible for reduced hepatic glucose production and gluconeogenesis by exogenous glucose in rats. Am J Physiol Endocrinol Metab 272: E163-E172, 1997.
16. Hue L. Regulation of gluconeogenesis in liver. In: Handbook of Physiology. The Endocrine Pancreas and Regulation of Metabolism. Bethesda, MD: Am. Physiol. Soc., 2001, sect. 7, vol. II, chapt. 20, p. 649-657.
17. Jungermann K and Katz N. Functional specialization of different hepatocyte populations. Physiol Rev 69: 708-764, 1989.
18. Kahn CR, Lauris V, Koch S, Crettaz M, and Granner DK. Acute and chronic regulation of phosphoenolpyruvate carboxykinase mRNA by insulin and glucose. Mol Endocrinol 3: 840-845, 1989.
19. Kuwajima M, Golden S, Katz J, Unger RH, Foster DW, and McGarry JD. Active hepatic glycogen synthesis from gluconeogenic precursors despite high tissue levels of fructose 2,6-bisphosphate. J Biol Chem 261: 2632-2637, 1986.
20. Lloyd B, Burrin J, Smythe P, and Alberti KG. Enzymic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate. Clin Chem 24: 1724-1729, 1978.
21. Mari A. Estimation of the rate of appearance in the non-steady state with a two-compartment model. Am J Physiol Endocrinol Metab 263: E400-E415, 1992.
22. Michal G. D-Glucose 6-phosphate and D-fructose 6-phosphate: D-glucopyranose 6-phosphate and D-fructofuranose 6-phosphate. In: Methods of Enzymatic Analysis, edited by Bergmeyer HU, Bergmeyer J, and Grabl M. Basel: Wiley, 1981, p. 191-198.
23. Moore MC, Cherrington AD, Cline G, Pagliassotti MJ, Jones EM, Neal DW, Badet C, and Shulman GI. Sources of carbon for hepatic glycogen synthesis in the conscious dog. J Clin Invest 88: 578-587, 1991.
24. Moore MC, Connolly CC, and Cherrington AD. Autoregulation of hepatic glucose production. Eur J Endocrinol 138: 240-248, 1998.
25. Moore MC, Pagliassotti MJ, Swift LL, Asher J, Murrell J, Neal D, and Cherrington AD. Disposition of a mixed meal by the conscious dog. Am J Physiol Endocrinol Metab 266: E666-E675, 1994.
26. Newgard CB, Moore SV, Foster DW, and McGarry JD. Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway. J Biol Chem 259: 6958-6963, 1984.
27. Pagliassotti MJ, Holste LC, Moore MC, Neal DW, and Cherrington AD. Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J Clin Invest 97: 81-91, 1996.
28. Petersen KF, Laurent D, Rothman DL, Cline GW, and Shulman GI. Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. J Clin Invest 101: 1203-1209, 1998.
29. Pilkis SJ and Granner DK. Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol 54: 885-909, 1992.
30. Previs SF, Martin SK, Hazey JW, Soloviev MV, Keating AP, Lucas D, David F, Koshy J, Kirschenbaum DW, Tserng KY, and Brunengraber H. Contributions of liver and kidneys to glycerol production and utilization in the dog. Am J Physiol Endocrinol Metab 271: E1118-E1124, 1996.
31. Radziuk J and Pye S. Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis. Diabetes Metab Res Rev 17: 250-272, 2001.
32. Randle PJ. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14: 263-283, 1998.
33. Randle PJ, Kerbey AL, and Espinal J. Mechanisms decreasing glucose oxidation in diabetes and starvation: role of lipid fuels and hormones. Diabetes Metab Rev 4: 623-638, 1988.
34. Randle PJ, Priestman DA, Mistry SC, and Halsall A. Glucose fatty acid interactions and the regulation of glucose disposal. J Cell Biochem 55: 1-11, 1994.
35. Roach PJ, Skurat AV, and Harris RA. Regulation of glycogen metabolism. In: Handbook of Physiology. The Endocrine Pancreas and Regulation of Metabolism. Bethesda, MD: Am. Physiol. Soc., 2001, sect. 7, vol. II, chapt. 19, p. 609-648.
36. Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G, and Hu M. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes. J Clin Invest 92: 1126-1134, 1993.
37. Scott DK, O'Doherty RM, Stafford JM, Newgard CB, and Granner DK. The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism. J Biol Chem 273: 24145-24151, 1998.
38. Shiota M, Galassetti P, Monohan M, Neal DW, and Cherrington AD. Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog. Diabetes 47: 867-873, 1998.
39. Shiota M, Jackson PA, Bischoff H, McCaleb M, Scott M, Monohan M, Neal DW, and Cherrington AD. Inhibition of glycogenolysis enhances gluconeogenic precursor uptake by the liver of conscious dogs. Am J Physiol Endocrinol Metab 273: E868-E879, 1997.
40. Shulman GI, Lacy WW, Liljenquist JE, Keller U, Williams PE, and Cherrington AD. Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog. J Clin Invest 65: 496-505, 1980.
41. Sindelar DK, Chu CA, Rohlie M, Neal DW, Swift LL, and Cherrington AD. The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog. Diabetes 46: 187-196, 1997.
42. Sindelar DK, Chu CA, Venson P, Donahue EP, Neal DW, and Cherrington AD. Basal hepatic glucose production is regulated by the portal vein insulin concentration. Diabetes 47: 523-529, 1998.
43. Stalmans W, Bollen M, and Mvumbi L. Control of glycogen synthesis in health and disease. Diabetes Metab Rev 3: 127-161, 1987.
44. Stanley JC, Dohm GL, McManus BS, and Newsholme EA. Activities of glucokinase and hexokinase in mammalian and avian livers. Biochem J 224: 667-671, 1984.
45. Sugden MC, Fryer LG, and Holness MJ. Regulation of hepatic pyruvate dehydrogenase kinase by insulin and dietary manipulation in vivo. Studies with the euglycaemic-hyperinsulinaemic clamp. Biochim Biophys Acta 1316: 114-120, 1996.
46. Van de Werve G and Jeanrenaud B. Liver glycogen metabolism: an overview. Diabetes Metab Rev 3: 47-78, 1987.
47. Williamson JR, Browning ET, and Scholz R. Control mechanisms of gluconeogenesis and ketogenesis. I. Effects of oleate on gluconeogenesis in perfused rat liver. J Biol Chem 244: 4607-4616, 1969.
48. Williamson JR, Kreisberg RA, and Felts PW. Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc Natl Acad Sci USA 56: 247-254, 1966.