메뉴 건너뛰기




Volumn 447, Issue 6, 2004, Pages 895-907

Functional characterization of the pentapeptide QYNAD on rNav1. 2 channels and its NMR structure

Author keywords

NMR; QYNAD; rNAv1.2 voltage gated sodium channels; Whole cell recordings

Indexed keywords

GLUTAMINYLTYROSYLASPARAGINYLALANYLASPARTIC ACID; ISOPROTEIN; PENTAPEPTIDE; SODIUM CHANNEL; SODIUM ION; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

EID: 1642395057     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-003-1194-9     Document Type: Article
Times cited : (7)

References (34)
  • 1
    • 5144233105 scopus 로고
    • MLEV-17 based two-dimensional homonuclear magnetization transfer spectroscopy
    • Bax A, Davis DG (1985) MLEV-17 based two-dimensional homonuclear magnetization transfer spectroscopy. J Magn Reson 65:355-360
    • (1985) J Magn Reson , vol.65 , pp. 355-360
    • Bax, A.1    Davis, D.G.2
  • 3
    • 0033943798 scopus 로고    scopus 로고
    • An endogenous pentapeptide acting as a sodium channel blocker in inflammatory autoimmune disorders of the central nervous system
    • Brinkmeier H, Aulkemeyer P, Wollinsky KH, Rudel R (2000) An endogenous pentapeptide acting as a sodium channel blocker in inflammatory autoimmune disorders of the central nervous system. Nat Med 6:808-811
    • (2000) Nat Med , vol.6 , pp. 808-811
    • Brinkmeier, H.1    Aulkemeyer, P.2    Wollinsky, K.H.3    Rudel, R.4
  • 4
    • 0033694833 scopus 로고    scopus 로고
    • From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels
    • Catterall WA (2000) From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26:13-25
    • (2000) Neuron , vol.26 , pp. 13-25
    • Catterall, W.A.1
  • 5
    • 0016792109 scopus 로고
    • Mechanism of frequency-dependent inhibition of sodium currents in the frog myelinated nerve by the lidocaine derivative GEA
    • Courtney KR (1975) Mechanism of frequency-dependent inhibition of sodium currents in the frog myelinated nerve by the lidocaine derivative GEA. J Pharmacol Exp Ther 195:225-236
    • (1975) J Pharmacol Exp Ther , vol.195 , pp. 225-236
    • Courtney, K.R.1
  • 11
    • 0030054376 scopus 로고    scopus 로고
    • Axonal channelopathies: An evolving concept in the pathogenesis of peripheral nerve disorders
    • Gutmann L, Gutmann L (1996) Axonal channelopathies: an evolving concept in the pathogenesis of peripheral nerve disorders. Neurology 47:18-21
    • (1996) Neurology , vol.47 , pp. 18-21
    • Gutmann, L.1    Gutmann, L.2
  • 12
    • 0028365121 scopus 로고
    • Block of the rat brain IIA sodium channel alpha subunit by the neuroprotective drug riluzole
    • Hebert T, Drapeau P, Pradier L, Dunn RJ (1994) Block of the rat brain IIA sodium channel alpha subunit by the neuroprotective drug riluzole. Mol Pharmacol 45:1055-1060
    • (1994) Mol Pharmacol , vol.45 , pp. 1055-1060
    • Hebert, T.1    Drapeau, P.2    Pradier, L.3    Dunn, R.J.4
  • 15
    • 0032212560 scopus 로고    scopus 로고
    • Mechanistic link between lidocaine block and inactivation probed by outer pore mutations in the rat ml skeletal muscle sodium channel
    • Lond
    • Kambouris NG, Hastings L, Stepanovic S, Marban E, Tomaselli GG, Balser JR (1998) Mechanistic link between lidocaine block and inactivation probed by outer pore mutations in the rat ml skeletal muscle sodium channel. J Physiol (Lond) 512:693-705
    • (1998) J Physiol , vol.512 , pp. 693-705
    • Kambouris, N.G.1    Hastings, L.2    Stepanovic, S.3    Marban, E.4    Tomaselli, G.G.5    Balser, J.R.6
  • 16
    • 0028204451 scopus 로고
    • Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy
    • Kraulis PJ, Domaille PJ, Campbell-Burk SL, Van Aken T, Laue ED (1994) Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy. Biochemistry 33:3515-3531
    • (1994) Biochemistry , vol.33 , pp. 3515-3531
    • Kraulis, P.J.1    Domaille, P.J.2    Campbell-Burk, S.L.3    Van Aken, T.4    Laue, E.D.5
  • 17
    • 0019327003 scopus 로고
    • A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross- relaxation networks in biological macromolecules
    • Kumar A, Ernst RR, Wuthrich K (1980) A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross- relaxation networks in biological macromolecules. Biochem Biophys Res Commun 95:1-6
    • (1980) Biochem Biophys Res Commun , vol.95 , pp. 1-6
    • Kumar, A.1    Ernst, R.R.2    Wuthrich, K.3
  • 19
    • 0021114895 scopus 로고
    • Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins
    • Marion D, Wuthrich K (1983) Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. Biochem Biophys Res Commun 113:967-974
    • (1983) Biochem Biophys Res Commun , vol.113 , pp. 967-974
    • Marion, D.1    Wuthrich, K.2
  • 20
    • 0023196614 scopus 로고
    • Action of benzocaine on sodium channels of frog nodes of Ranvier treated with chloramine-T
    • Meeder T, Ulbricht W (1987) Action of benzocaine on sodium channels of frog nodes of Ranvier treated with chloramine-T. Pflügers Arch 409:265-273
    • (1987) Pflügers Arch , vol.409 , pp. 265-273
    • Meeder, T.1    Ulbricht, W.2
  • 21
    • 0023374854 scopus 로고
    • Mapping a region associated with Na channel inactivation using antibodies to a synthetic peptide corresponding to a part of the channel
    • Meiri H, Spira G, Sammar M, Namir M, Schwartz A, Komoriya A, Kosower EM, Palti Y (1987) Mapping a region associated with Na channel inactivation using antibodies to a synthetic peptide corresponding to a part of the channel. Proc Natl Acad Sci USA 84:5058-5062
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 5058-5062
    • Meiri, H.1    Spira, G.2    Sammar, M.3    Namir, M.4    Schwartz, A.5    Komoriya, A.6    Kosower, E.M.7    Palti, Y.8
  • 22
    • 0026951903 scopus 로고
    • Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions
    • Piotto M, Saudek V, Sklenar V (1992) Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. J Biomol NMR 2:661-665
    • (1992) J Biomol NMR , vol.2 , pp. 661-665
    • Piotto, M.1    Saudek, V.2    Sklenar, V.3
  • 23
    • 0025827588 scopus 로고
    • + channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs
    • + channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs. Mol Pharmacol 40:756-765
    • (1991) Mol Pharmacol , vol.40 , pp. 756-765
    • Ragsdale, D.S.1    Scheuer, T.2    Catterall, W.A.3
  • 24
    • 0027944683 scopus 로고
    • Molecular determinants of state-dependent block of Na+ channels by local anesthetics
    • Ragsdale DS, McPhee JC, Scheuer T, Catterall WA (1994) Molecular determinants of state-dependent block of Na+ channels by local anesthetics. Science 265:1724-1728
    • (1994) Science , vol.265 , pp. 1724-1728
    • Ragsdale, D.S.1    McPhee, J.C.2    Scheuer, T.3    Catterall, W.A.4
  • 25
    • 0001682506 scopus 로고
    • High level stable expression of rat brain type IIA sodium channel alpha subunit in CHO cells
    • India
    • Sarkar SN, Sikdar SK (1994) High level stable expression of rat brain type IIA sodium channel alpha subunit in CHO cells. Curr Sci (India) 67:196-199
    • (1994) Curr Sci , vol.67 , pp. 196-199
    • Sarkar, S.N.1    Sikdar, S.K.2
  • 26
    • 0028824677 scopus 로고
    • Kinetic characterization of rat brain type IIA sodium channel alpha-subunit stably expressed in a somatic cell line
    • Lond
    • Sarkar SN, Adhikari A, Sikdar SK (1995) Kinetic characterization of rat brain type IIA sodium channel alpha-subunit stably expressed in a somatic cell line. J Physiol (Lond) 488:633-645
    • (1995) J Physiol , vol.488 , pp. 633-645
    • Sarkar, S.N.1    Adhikari, A.2    Sikdar, S.K.3
  • 27
    • 0031443441 scopus 로고    scopus 로고
    • Sodium channel selectivity filter regulates antiarrhythmic drug binding
    • Sunami A, Dudley SC Jr, Fozzard HA (1997) Sodium channel selectivity filter regulates antiarrhythmic drug binding. Proc Natl Acad Sci USA 94:14126-14131
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14126-14131
    • Sunami, A.1    Dudley Jr., S.C.2    Fozzard, H.A.3
  • 29
    • 0024522273 scopus 로고
    • Sodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiological characteristics and their modification by diphenylhydantoin
    • Tomaselli GF, Marben E, Yellen G (1989) Sodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiological characteristics and their modification by diphenylhydantoin. J Clin Invest 83:1724-1732
    • (1989) J Clin Invest , vol.83 , pp. 1724-1732
    • Tomaselli, G.F.1    Marben, E.2    Yellen, G.3
  • 30
    • 0030753096 scopus 로고    scopus 로고
    • + channel pores revealed by single- and double-cysteine replacements
    • + channel pores revealed by single- and double-cysteine replacements. J Gen Physiol 110:59-72
    • (1997) J Gen Physiol , vol.110 , pp. 59-72
    • Tsushima, R.G.1    Li, R.A.2    Backx, P.H.3
  • 31
    • 0036874286 scopus 로고    scopus 로고
    • Unblocked statistical-coil tetrapeptides and pentapeptides in aqueous solution: A theoretical study
    • Vila JA, Ripoll DR, Baldoni HA, Scheraga HA (2002) Unblocked statistical-coil tetrapeptides and pentapeptides in aqueous solution: a theoretical study. J Biomol NMR 24:245-262
    • (2002) J Biomol NMR , vol.24 , pp. 245-262
    • Vila, J.A.1    Ripoll, D.R.2    Baldoni, H.A.3    Scheraga, H.A.4
  • 32
    • 0028921909 scopus 로고
    • Sodium channel blockade by antibodies: A new mechanism of neurological disease?
    • Waxman SG (1995) Sodium channel blockade by antibodies: a new mechanism of neurological disease? Ann Neurol 37:421-423
    • (1995) Ann Neurol , vol.37 , pp. 421-423
    • Waxman, S.G.1
  • 33
    • 0037016517 scopus 로고    scopus 로고
    • The endogenous pentapeptide QYNAD induces acute conduction block in the isolated rat sciatic nerve
    • Weber F, Rudel R, Aulkemeyer P, Brinkmeier H (2002) The endogenous pentapeptide QYNAD induces acute conduction block in the isolated rat sciatic nerve. Neurosci Lett 317:33-36
    • (2002) Neurosci Lett , vol.317 , pp. 33-36
    • Weber, F.1    Rudel, R.2    Aulkemeyer, P.3    Brinkmeier, H.4
  • 34
    • 0029015016 scopus 로고
    • Cerebrospinal fluid and serum from patients with inflammatory polyradiculoneuropathy have opposite effects on sodium channels
    • Wurz A, Brinkmeier H, Wollinsky KH, Mehrkens HH, Kornhuber HH, Rudel R (1995) Cerebrospinal fluid and serum from patients with inflammatory polyradiculoneuropathy have opposite effects on sodium channels. Muscle Nerve 18:772-781
    • (1995) Muscle Nerve , vol.18 , pp. 772-781
    • Wurz, A.1    Brinkmeier, H.2    Wollinsky, K.H.3    Mehrkens, H.H.4    Kornhuber, H.H.5    Rudel, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.