Regulation of human IL-18 gene expression: Interaction of PU.1 with GC-box binding protein is involved in human IL-18 expression in myeloid cells

European Journal of Immunology

Volumn 34, Issue 3, 2004, Pages 817-826

  Koyama, Noriko ^a,b   Hoelzer, Dieter ^a   Ottmann, Oliver G ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

GC rich region; Gene regulation; IL 18; Myeloid cells; PU.1; Sodium butyrate

Indexed keywords

BINDING PROTEIN; BUTYRIC ACID; CELL DNA; CIS ACTING ELEMENT; INTERLEUKIN 18; TRANSCRIPTION FACTOR PU 1; DNA; DNA BINDING PROTEIN; ONCOPROTEIN; PROTO ONCOGENE PROTEIN SPI 1; PROTO-ONCOGENE PROTEIN SPI-1; TRANSACTIVATOR PROTEIN;

ARTICLE; BINDING SITE; BONE MARROW CELL; COMPLEX FORMATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; DNA DETERMINATION; GC RICH SEQUENCE; GEL MOBILITY SHIFT ASSAY; GENE ACTIVITY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE OVEREXPRESSION; GENE STRUCTURE; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; BIOSYNTHESIS; CELL LINE; CELL STRAIN U937; CHEMISTRY; GENETICS; IMMUNOLOGY; METABOLISM; NUCLEOTIDE SEQUENCE; REGULATORY SEQUENCE;

BASE SEQUENCE; CELL LINE; DNA; DNA-BINDING PROTEINS; GC RICH SEQUENCE; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-18; MYELOID CELLS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; U937 CELLS;

EID: 1642386290     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324420     Document Type: Article

References (43)

1. Okamura, H., Tsutsi, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K. et al., Cloning of a new cytokine that induces IFN-gamma production by T cells, Nature 1995. 378: 88-91.
2. Dinarello, C. A., Interleukin-18. Methods 1999. 19: 121-132.
3. Akira, S., The role of IL-18 in innate immunity. Curr. Opin. Immunol. 2000. 12: 59-63.
4. Micallef, M. J., Ohtsuki, T., Kohno, K., Tanabe, F., Ushio, S., Namba, M., Tanimoto, T., Torigoe, K., Fujii, M., Ikeda, M., Fukuda, S. and Kurimoto, M., Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human Tcells: synergism with interleukin-12 for interferongamma production. Eur. J. Immunol. 1996. 26:1647-1651.
5. Tsutsui, H., Nakanishi, K., Matsui, K., Higashino, K., Okamura, H., Miyazawa, Y. and Kaneda, K., IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones. J. Immunol. 1996. 157: 3967-3973.
6. Ushio, S., Namba, M., Okura, T., Hattori, K., Nukada, Y., Akita, K., Tanabe, F., Konishi, K., Micallef, M., Fujii, M., Torigoe, K., Tanimoto, T., Fukuda, S., Ikeda, M., Okamura, H. and Kurimoto, M., Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J. Immunol. 1996. 156: 4274-4279.
7. + human blood mononuclear cells. J. Clin. Invest. 1998. 101: 711-721.
8. Xu, D., Trajkovic, V., Hunter, D., Leung, B. P., Schulz, K., Gracie, J. A., McInnes, I. B. and Liew, F. Y., IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background. Eur. J. Immunol. 2000. 30: 3147-3156.
9. Hoshino, T., Wiltrout, R. H. and Young, H. A., IL-18 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response. J. Immunol. 1999. 162: 5070-5077.
10. Osaki, T., Peron, J. M., Cai, Q., Okamura, H., Robbins, P. D., Kurimoto, M., Lotze, M. T. and Tahara, H., IFN-gamma-inducing factor/IL-18 administration mediates IFN-gamma- and IL-12-independent antitumor effects. J. Immunol. 1998. 160: 1742-1749.
11. Coughlin, C. M., Salhany, K. E., Wysocka, M., Aruga, E., Kurzawa, H., Chang, A. E., Hunter, C. A., Fox, J. C., Trinchieri, G. and Lee, W. M., Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis. J. Clin. Invest. 1998. 101: 1441-1452.
12. Gracie, J. A., Robertson, S. E. and McInnes, I. B., Interleukin-18. J. Leukoc. Biol. 2003. 73: 213-224.
13. Nicoletti, F., Conget, I., Di Marco, R., Speciale, A. M., Morinigo, R., Bendtzen, K. and Gomis, R., Serum levels of the interferon-gamma-inducing cytokine interleukin-18 are increased in individuals at high risk of developing type 1 diabetes. Diabetologia 2001. 44: 309-311.
14. Moller, B., Kukoc-Zivojnov, N., Kessler, U., Rehart, S., Kaltwasser, J. P., Hoelzer, D., Kalina, U. and Ottmann, O. G., Expression of interleukin-18 and its monokine-directed function in rheumatoid arthritis. Rheumatology 2001. 40: 302-309.
15. Kanai, T., Watanabe, M., Okazawa, A., Nakamaru, K., Okamoto, M., Naganuma, M., Ishii, H., Ikeda, M., Kurimoto, M. and Hibi, T., Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease. Gastroenterology 2000. 119: 1514-1523.
16. Sugiura, T., Kawaguchi, Y., Harigai, M., Terajima-Ichida, H., Kitamura, Y., Furuya, T., Ichikawa, N., Kotake, S., Tanaka, M., Hara, M. and Kamatani, N., Association between adult-onset Still's disease and interleukin-18 gene polymorphisms. Genes Immun. 2002. 3: 394-399.
17. Kretowski, A., Mironczuk, K., Karpinska, A., Bojaryn, U., Kinalski, M., Puchalski, Z. and Kinalska, I., Interleukin-18 promoter polymorphisms in type 1 diabetes. Diabetes 2002. 51: 3347-3349.
18. Pirhonen, J., Sareneva, T., Kurimoto, M., Julkunen, I. and Matikainen, S., Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway. J. Immunol. 1999. 162: 7322-7329.
19. Kalina, U., Ballas, K., Koyama, N., Kauschat, D., Miething, C., Arnemann, J., Martin, H., Hoelzer, D. and Ottmann, O. G., Genomic organization and regulation of the human interleukin-18 gene. Scand. J. Immunol. 2000. 52: 525-530.
20. Koyama, N., Koschmieder, S., Tyagi, S., Nurnberger, H., Wagner, S., Bocker, U., Hoelzer, D., Ottmann, O. G. and Kalina, U., Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells. Biochem. Biophys. Res. Commun. 2002. 292: 937-943.
21. Kalina, U., Koyama, N., Hosoda, T., Nuernberger, H., Sato, K., Hoelzer, D., Herweck, F., Manigold, T., Singer, M. V., Rossol, S. and Bocker, U., Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region. Eur. J. Immunol. 2002. 32: 2635-2643.
22. Tenen, D. G., Hromas, R., Licht, J. D. and Zhang, D. E., Transcription factors, normal myeloid development, and leukemia. Blood 1997. 90: 489-519.
23. Hohaus, S., Petrovick, M. S., Voso, M. T., Sun, Z., Zhang, D. E. and Tenen, D. G., PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene. Mol. Cell. Biol. 1995. 15: 5830-5845.
24. Rehli, M., Poltorak, A., Schwarzfischer, L., Krause, S. W., Andreesen, R. and Beutler, B., PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. J. Biol. Chem. 2000. 275: 9773-9781.
25. Pahl, H. L., Scheibe, R. J., Zhang, D. E., Chen, H. M., Galson, D. L., Maki, R. A. and Tenen, D. G., The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter. J. Biol. Chem. 1993. 268: 5014-5020.
26. Li, S. L., Valente, A. J., Zhao, S. J. and Clark, R. A., PU.1 is essential for p47(phox) promoter activity in myeloid cells. J. Biol. Chem. 1997. 272: 17802-17809.
27. Hagemeier, C., Bannister, A. J., Cook, A. and Kouzarides, T., The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. Proc. Natl. Acad. Sci. USA 1993. 90: 1580-1584.
28. Kim, Y. M., Kang, H. S., Paik, S. G., Pyun, K. H., Anderson, K. L., Torbett, B. E. and Choi, I., Roles of IFN consensus sequence binding protein and PU.1 in regulating IL-18 gene expression. J. Immunol. 1999. 163: 2000-2007.
29. Tone, M., Thompson, S. A., Tone, Y., Fairchild, P. J. and Waldmann, H., Regulation of IL-18 (IFN-gamma-inducing factor) gene expression. J. Immunol. 1997. 159: 6156-6163.
30. Giedraitis, V., He, B., Huang, W. X. and Hillert, J., Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation. J. Neuroimmunol. 2001. 112: 146-152.
31. Hagen, G., Muller, S., Beato, M. and Suske, G., Sp1-mediated transcriptional activation is repressed by Sp3. EMBO J. 1994. 13: 3843-3851.
32. Dynan, W. S. and Tjian, R., The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell 1983. 35: 79-87.
33. Puren, A. J., Fantuzzi, G. and Dinarello, C. A., Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1 beta are differentially regulated in human blood mononuclear cells and mouse spleen cells. Proc. Natl. Acad. Sci. USA 1999. 96: 2256-2261.
34. Newmark, H. L., Lupton, J. R. and Young, C. W., Butyrate as a differentiating agent: pharmacokinetics, analogues and current status. Cancer Lett. 1994. 78: 1-5.
35. Boffa, L. C., Vidali, G., Mann, R. S. and Allfrey, V. G., Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J. Biol. Chem. 1978. 253: 3364-3366.
36. Witt, O., Sand, K. and Pekrun, A., Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways. Blood 2000. 95: 2391-2396.
37. Boosalis, M. S., Bandyopadhyay, R., Bresnick, E. H., Pace, B. S., Van DeMark, K., Zhang, B., Faller, D. V. and Perrine, S. P., Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation. Blood 2001. 97: 3259-3267.
38. Laribee, R. N. and Klemsz, M. J., Loss of PU.1 expression following inhibition of histone deacetylases. J. Immunol. 2001. 167: 5160-5166.
39. Nakano, K., Mizuno, T, Sowa, Y., Orita, T., Yoshino, T., Okuyama, Y., Fujita, T., Ohtani-Fujita, N., Matsukawa, Y., Tokino, T., Yamagishi, H., Oka, T, Nomura, H. and Sakai, T., Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. J. Biol. Chem. 1997. 272: 22199-22206.
40. Walker, G. E., Wilson, E. M., Powell, D. and Oh, Y., Butyrate, a histone deacetylase inhibitor, activates the human IGF binding protein-3 promoter in breast cancer cells: molecular mechanism involves an Sp1/Sp3 multiprotein complex. Endocrinology 2001. 142: 3817-3827.
41. Schule, R., Muller, M., Otsuka-Murakami, H. and Renkawitz, R., Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor. Nature 1988. 332: 87-90.
42. Gobin, S. J., van Zutphen, M., Westerheide, S. D., Boss, J. M. and van den Elsen, P. J., The MHC-specific enhanceosome and its role in MHC class I and beta(2)-microglobulin gene transactivation. J. Immunol. 2001. 167: 5175-5184.
43. Baudler, M., Duschl, J., Winkler, C., Schartl, M. and Altschmied, J., Activation of transcription of the melanoma inducing Xmrk oncogene by a GC box element. J. Biol. Chem. 1997. 272: 131-137.