The MHC-specific enhanceosome and its role in MHC class I and β2-microglobulin gene transactivation

Journal of Immunology

Volumn 167, Issue 9, 2001, Pages 5175-5184

  Gobin, S J P ^a   Van Zutphen, M ^a   Westerheide, S D ^a   Boss, J M ^a   Van den Elsen, P J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NUCLEAR FACTOR; NUCLEAR FACTOR Y; PROTEIN P300; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REGULATOR GENE; REGULATORY MECHANISM; TRANSACTIVATION;

EID: 0035500643     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.9.5175     Document Type: Article

References (40)

1. The bare lymphocyte syndrome and the regulation of MHC expression
2. The bare lymphocyte syndrome: Molecular clues to the transcriptional regulation of major histocompatibility complex class II genes
3. Site α is crucial for two routes of IFN-γ-induced MHC class I transactivation: The ISRE mediated route and a novel pathway involving CIITA
4. Induction of MHC class I expression by the MHC class II transactivator CIITA
5. Shared regulatory elements in the promoters of MHC class I and class II genes
6. 2-microglobulin genes
7. Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B-deficient cells
8. The pentanucleotide ATTGG, the "inverted CCAAT," is an essential element for HLA class I gene transcription
9. Formation of a regulatory factor X/X2 Box-binding protein nuclear factor-Y multiprotein complex on the conserved regulatory regions on HLA class II genes
10. Assembly of functional regulatory complexes on MHC class II promoters in vivo
11. The enhanceosome and transcriptional synergy
12. Defective MHC class II expression in an MHC class II deficiency patient is caused by a novel deletion of a splice donor site in the MHC class II transactivator gene
13. Molecular analysis of an MHC class II deficiency patient reveals a novel mutation in the RFX5 gene
14. Introduction of exogenous class II trans-activator in MHC class II-deficient AB1 fibroblasts results in incomplete rescue of MHC class II antigen expression
15. In vivo footprinting of a muscle specific enhancer by ligation mediated PCR
16. HLA-DMA and HLA-DMB gene expression functions through the conserved SXY region
17. The role of enhancer A in the locus-specific regulation of classical and non-classical HLA class I genes by NF-κB
18. Transactivation of classical and nonclassical HLA class I genes through the IFN-stimulated response element
19. Locus-specific regulation of HLA-A and HLA-B expression is not determined by nucleotide variation in the X2 box promoter element
20. Promoter accessibility within the environment of MHC is affected in class II-deficient combined immunodeficiency
21. HLA-A class I allele HLA-A2 expression defect associated with a mutation in its enhancer B inverted CAT in two families
22. 5′ regulatory nucleotide sequence of an HLA*0101 null allele
23. The molecular biology of the CCAAT-binding factor NF-Y
24. CCAAT-binding factor NF-Y and RFX are required for in vivo assembly of a nucleoprotein complex that spans 250 base pairs: The invariant chain as a model
25. Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter
26. Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex
27. Mutational analysis of the MHC class II transactivator CIITA indicates a functional requirement for conserved LCD motifs and for interactions with the conserved W-box promoter element
28. Orientation and positional mapping of the subunits of the multicomponent transcription factors RFX and X2BP to the major histocompatibility complex class II transcriptional enhancer
29. Class II transactivator: Mastering the art of major histocompatibility complex expression
30. Associations and interactions between bare lymphocyte syndrome factors
31. A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y
32. CIITA is a transcriptional coactivator that is required to MHC class II promoters by multiple synergistic interaction with an enhanceosome complex
33. Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein
34. Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5
35. The class II trans-activator CIITA interacts with the TBP-associated factor TAFII33
36. Acetylation of histones and transcriptionrelated factors
37. Involvement of CREB binding protein in expression of major histocompatibility complex class II genes via interaction with the class II transactivator
38. Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes
39. Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes
40. Transcriptional regulation by cyclic AMP