Effects of a Novel Cardioselective ATP-Sensitive Potassium Channel Antagonist, 1-[[5-[2-(5-Chloro-o-anisamido)ethyl]-β -methoxyethoxyphenyl]sulfonyl]-3-methylthiourea, Sodium Salt (HMR 1402), on Susceptibility to Ventricular Fibrillation Induced by Myocardial Ischemia: In Vitro and in Vivo Studies

Journal of Pharmacology and Experimental Therapeutics

Volumn 309, Issue 1, 2004, Pages 182-192

  Billman, George E ^a   Houle, Melanie S ^a   Englert, Heinrich C ^b   Gögelein, Heinz ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 [5 [2 (5 CHLORO 2 ANISAMIDO)ETHYL] BETA METHOXYETHOXYPHENYL]SULFONYL 3 METHYLTHIOUREA; DIAZOXIDE; GLIBENCLAMIDE; HMR 1402; POTASSIUM CHANNEL BLOCKING AGENT; RILMAKALIM; SODIUM; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DOG; DRUG SELECTIVITY; EXERCISE TEST; GLUCOSE BLOOD LEVEL; GUINEA PIG; HEART MUSCLE ISCHEMIA; HEART VENTRICLE FIBRILLATION; HYPERPOLARIZATION; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; MUSCLE CELL; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REPOLARIZATION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; DOGS; FEMALE; GUINEA PIGS; HEART; HYPEREMIA; ISLETS OF LANGERHANS; MALE; MYOCARDIAL ISCHEMIA; PAPILLARY MUSCLES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RATS, SPRAGUE-DAWLEY; THIOUREA; VENTRICULAR FIBRILLATION;

EID: 1642374380     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.061416     Document Type: Article

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