Cardioselectivity of the sulphonylurea HMR 1098: Studies on native and recombinant cardiac and pancreatic KATP channels

British Journal of Pharmacology

Volumn 135, Issue 2, 2002, Pages 480-488

  Manning Fox, Jocelyn E ^a   Kanji, Hussein D ^b   French, Robert J ^b   Light, Peter E ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Heart; Pancreas; Patch clamp; Sulphonylureas; cell

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CLAMIKALANT; POTASSIUM CHANNEL; RECOMBINANT PROTEIN; SULFONYLUREA DERIVATIVE; SULFONYLUREA RECEPTOR;

ANIMAL CELL; ARTICLE; CARDIOSELECTIVITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG SELECTIVITY; DRUG STRUCTURE; HEART; HEART VENTRICLE WALL; HUMAN; HUMAN CELL; IC 50; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS; PATCH CLAMP; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZAMIDES; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICE; MYOCARDIUM; PANCREAS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN ISOFORMS; RATS; RECOMBINANT PROTEINS; SULFONYLUREA COMPOUNDS;

EID: 0036181418     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704455     Document Type: Article

References (23)

1. Molecular biology of ATP-sensitive potassium channels
2. Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel
3. Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP
4. Sulfonylurea drugs increase early mortality in patients with diabetes mellitus after direct angioplasty for acute myocardial infarction
5. Molecular basis, pharmacology and physiological role of cardiac K(ATP) channels
6. HMR 1883, a novel cardioselective inhibitor of the ATP-sensitive potassium channel. Part I: Effects on cardiomyocytes, coronary flow and pancreatic beta-cells
7. + channel currents expressed in Xenopus oocytes: A reinterpretation
8. Tissue specificity of sulfonylureas: Studies on cloned cardiac and beta-cell K(ATP) channels
9. ATP channels in cardioprotection
10. + channels and myocardial preconditioning
11. ATP: An inward rectifier subunit plus the sulfonylurea receptor
12. + channels
13. Primary structure and functional expression of a mouse inward rectifier potassium channel
14. Sulphonylurea treatment of NIDDM patients with cardiovascular disease: A mixed blessing?
15. Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels
16. Hypothyroidism decreases the ATP-sensitivity of KATP channels from rat heart
17. Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels
18. Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel
19. ATP-sensitive potassium channels: A model of heteromultimeric potassium channel/receptor assemblies
20. Cardiovascular effects of sulphonylurea derivatives. Implications for the treatment of NIDDM?
21. Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels
22. + channels in the absence of the sulphonylurea receptor
23. K(ATP) channel blocker HMR 1883 reduces monophasic action potential shortening during coronary ischemia in anesthetised pigs