Anaesthesia in elderly patients with neurodegenerative disorders: Special considerations

Drugs and Aging

Volumn 21, Issue 4, 2004, Pages 229-242

  Burton, Deborah A ^a   Nicholson, Grainne ^a   Hall, George M ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; ANTIEMETIC AGENT; ANTIPARKINSON AGENT; BENZODIAZEPINE DERIVATIVE; BROMOCRIPTINE; BUTYROPHENONE DERIVATIVE; CATECHOLAMINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINESTERASE INHIBITOR; CLOMIPRAMINE; DOSULEPIN; EPHEDRINE; FLUDROCORTISONE; FLUOXETINE; GLYCOPYRRONIUM BROMIDE; HALOTHANE; IMIPRAMINE; INHALATION ANESTHETIC AGENT; LEVODOPA; METOCLOPRAMIDE; MONOAMINE OXIDASE INHIBITOR; NEUROLEPTIC AGENT; NEUROMUSCULAR BLOCKING AGENT; OCTREOTIDE; OPIATE; PHENOTHIAZINE DERIVATIVE; PROPOFOL; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG;

AGED; AGITATION; ALZHEIMER DISEASE; ANESTHESIA; ANESTHESIA INDUCTION; BLOOD BRAIN BARRIER; BLOOD VOLUME; BRAIN ATROPHY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; CONFUSION; CONSTIPATION; DEGENERATIVE DISEASE; DEMENTIA; DIGESTIVE SYSTEM FUNCTION DISORDER; DRUG ABSORPTION; DRUG DEGRADATION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG TRANSPORT; GENERAL ANESTHESIA; HEART ARRHYTHMIA; HEART OUTPUT; HUMAN; HUNTINGTON CHOREA; HYPERPYREXIA; INSOMNIA; INVOLUNTARY MOVEMENT; LOW DRUG DOSE; MULTIINFARCT DEMENTIA; MUSCLE RIGIDITY; ORTHOSTATIC HYPOTENSION; PARKINSON DISEASE; PARKINSONISM; PATHOGENESIS; PHARMACODYNAMICS; POLYPHARMACY; PREOPERATIVE EVALUATION; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; REGIONAL ANESTHESIA; RESPIRATORY SYSTEM; REVIEW; SALT INTAKE; SEDATION; SEIZURE; SIDE EFFECT; SWEATING; TACHYCARDIA; URINE RETENTION; VISUAL IMPAIRMENT; XEROSTOMIA;

AGED; AGED, 80 AND OVER; ANESTHESIA; CENTRAL NERVOUS SYSTEM AGENTS; DRUG INTERACTIONS; HUMANS; NERVOUS SYSTEM DISEASES; POLYPHARMACY; POSTOPERATIVE PERIOD;

EID: 1642362776     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-200421040-00002     Document Type: Review

References (110)

1. World population prospects: 2000 revision. New York: Population Division, Department of Economic and Social Affairs, United Nations, 2000: 14-6
2. National Confidential Enquiry into Perioperative Deaths. Extremes of age. London: NCEPOD, 1999: 59
3. LeMay M. Radiologic changes of the aging brain and skull. AJR Am J Roentgenol 1984; 143: 383-9
4. Katzman R. Medical progress: Alzheimer's disease. N Engl J Med 1986; 314: 964-71
5. Prusiner SB. Shattock lecture: neurodegenerative diseases and prions. N Engl J Med 2001; 344: 1516-26
6. Perry EK, Martin-Ruiz CM, Court JA. Nicotinic receptor subtypes in human brain related to aging and dementia. Alcohol 2001; 24: 63-8
7. Nakamura S, Takahashi T, Yamashita H, et al. Nicotinic acetylcholine receptors and neurodegenerative disease. Alcohol 2001; 24: 79-81
8. Hebert LE, Scherr PA, Beckett LA, et al. Age-specific incidence of Alzheimer's disease in a community population. JAMA 1995; 273: 1354-9
9. Ott A, Breteler MMB, van Harskamp F, et al. Prevalence of Alzheimer's disease and vascular dementia: association with education: the Rotterdam Study. BMJ 1995; 310: 970-3
10. Evans DA, Funkenstein HH, Albert MS, et al. Prevalence of Alzheimer's disease in a community population of older persons: higher than previously reported. JAMA 1989; 262: 2551-6
11. Pfeffer RI, Afifi AA, Chance JM. Prevalence of Alzheimer's disease in a retirement community. Am J Epidemiol 1987; 125: 420-36
12. Kuusisto J, Koivisto K, Kervinen K, et al. Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study. BMJ 1994; 309: 636-8
13. Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261: 921-3
14. Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E ε4 with late-onset familial and sporadic Alzheimer's disease. Lancet 1993; 342: 710-1
15. Poirier J, Davignon J, Bouthillier D, et al. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 1993; 342: 697-9
16. Seshadri S, Drachman DA, Lippa CF. Apolipoprotein E ε4 allele and the lifetime risk of Alzheimer's disease: what physicians know, and what they should know. Arch Neurol 1995; 52: 1074-9
17. Mortimer JA, van Duijn CM, Chandra V, et al. Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies. Int J Epidemiol 1991; 20 Suppl. 2: S28-35
18. Breteler MMB, van Duijn CM, Chandra V, et al. Medical history and the risk of Alzheimer's disease: a collaborative reanalysis of case-control studies. Int J Epidemiol 1991; 20 Suppl. 2: S36-42
19. Stern Y, Gurland B, Thomas K, et al. Influence of education and occupation on the incidence of Alzheimer's disease. JAMA 1994; 271: 1004-10
20. Fratiglioni L, Wang H-X. Smoking and Parkinson's and Alzheimer's disease: review of the epidemiological studies. Behav Brain Res 2000; 113: 117-20
21. George AE, Leon MJ, Rosenbloom S, et al. Ventricular volume and cognitive deficit: a computed tomographic study. Radiology 1983; 149: 493-8
22. Richards M, Touchon J, Ledesert B, et al. Mild extrapyramidal signs and functional impairment in ageing. Int J Geriatr Psychiatry 2002; 17: 150-3
23. Bennett DA, Beckett LA, Murray AM, et al. Prevalence of parkinsonian signs and associated mortality in a community population of older people. N Engl J Med 1996; 334: 71-6
24. Hughes TA, Ross HF, Musa S, et al. A 10-year study of the incidence of and factors predicting dementia in Parkinson's disease. Neurology 2000; 54: 1596-603
25. Levy G, Tang M-X, Louis ED, et al. The association of incident dementia with mortality in Parkinson's disease. Neurology 2002; 59: 1708-13
26. Mouradian MM. Recent advances in the genetics and pathogenesis of Parkinson's disease. Neurology 2002; 58: 179-85
27. Piccini P, Burn DJ, Ceravolo R, et al. The role of inheritance in sporadic Parkinson's disease: evidence from a longitudinal study of dopaminergic function in twins. Ann Neurol 1999; 45: 577-82
28. Maat-Kievit A, Losekoot M, Zwinderman K, et al. Predictability of age at onset in Huntington disease in the Dutch population. Medicine 2002; 81: 251-9
29. Myers RH, Sax DS, Schoenfeld M, et al. Late onset of Huntington's disease. J Neurol Neurosurg Psychiatry 1985; 48: 530-4
30. Collins S, Boyd A, Fletcher A, et al. Novel prion protein gene mutation in an octogenarian with Creutzfeldt-Jakob disease. Arch Neurol 2000; 57: 1058-63
31. de Silva R, Findlay C, Awad I, et al. Creutzfeldt-Jakob disease in the elderly. Postgrad Med J 1997; 73: 557-9
32. Cousens SN, Zeidler M, Esmonde TF, et al. Sporadic Creutzfeldt-Jakob disease in the United Kingdom: analysis of epidemiological surveillance data for 1970-96. BMJ 1997; 315: 389-95
33. McLachlan MSF. The ageing kidney. Lancet 1978; II: 143-5
34. Wynne HA, Cope LH, Mutch E, et al. The effect of age upon liver volume and apparent liver flow in healthy man. Hepatology 1989; 9: 297-301
35. Ray WA, Griffin MR, Schaffner W, et al. Psychotropic drug use and the risk of hip fracture. N Engl J Med 1987; 316: 363-9
36. Nolan L, O'Malley K. Prescribing for the elderly (Part I): sensitivity of the elderly to adverse drug reactions. J Am Geriatr Soc 1988; 36: 142-9
37. Mamdani MM, Parikh SV, Austin PC, et al. Use of antidepressants among elderly subjects: trends and contributing factors. Am J Psychiatry 2000; 157: 360-7
38. Mittmann N, Herrmann N, Einarson TR, et al. The efficacy, safety and tolerability of antidepressants in late life depression: a meta-analysis. J Affect Disord 1997; 46: 191-217
39. Kirby M, Denihan A, Bruce I, et al. Benzodiazepine use among the elderly in the community. Int J Geriatr Psychiatry 1999; 14: 280-4
40. Castleden CM, George CF, Marcer D, et al. Increased sensitivity to nitrazepam in old age. BMJ 1977; I: 10-2
41. van Dijk KN, de Vries CS, ter Huurne K, et al. Concomitant prescribing of benzodiazepines during antidepressant therapy in the elderly. J Clin Epidemiol 2002; 55: 1049-53
42. Caligiuri MP, Lacro JP, Jeste DV. Incidence and predictors of drug-induced Parkinsonism in older psychiatric patients treated with very low doses of neuroleptics. J Clin Psychopharmacol 1999; 19: 322-8
43. Woerner MG, Alvir JM, Saltz BL, et al. Prospective study of tardive dyskinesia in the elderly: rates and risk factors. Am J Psychiatry 1998; 155: 1521-8
44. Smith JM, Baldessarini RJ. Changes in prevalence, severity, and recovery in tardive dyskinesia with age. Arch Gen Psychiatry 1980; 37: 1368-73
45. Ros̈ler M, Anand R, Cicin-Sain A, et al. Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international, randomised controlled trial. BMJ 1999; 318: 633-40
46. Levy ML, Cummings JL, Kahn-Rose R. Neuropsychiatric symptoms and cholinergic therapy for Alzheimer's disease. Gerontology 1999; 45: 15-22
47. Small GW, Rabins PV, Barry PP, et al. Diagnosis and treatment of Alzheimer disease and related disorders: consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association and the American Geriatrics Society. JAMA 1997; 278: 1363-71
48. Marsden CD, Parkes JD. Success and problems of long-term levodopa therapy in Parkinson's disease. Lancet 1977; I (8007): 345-9
49. Koller WC. Neuroprotection for Parkinson's disease. Ann Neurol 1998; 44: S155-9
50. The Parkinson Study Group. Effect of deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 1989; 321: 1364-71
51. Münchau A, Bhatia KP. Pharmacological treatment of Parkinson's disease. Postgrad Med J 2000; 76: 602-10
52. Orr HT, Zoghbi HY. Reversing neurodegeneration: a promise unfolds. Cell 2000; 101: 1-4
53. Rabins PV, Folstein MF. Delirium and dementia: diagnostic criteria and fatality rates. Br J Psychiatry 1982; 140: 149-53
54. Larson EB, Kukull WA, Buchner D, et al. Adverse drug reactions associated with global cognitive impairment in elderly persons. Ann Intern Med 1987; 107: 169-73
55. Bohnen N, Warner MA, Kokmen E, et al. Early and midlife exposure to anesthesia and age of onset of Alzheimer's disease. Int J Neurosci 1994; 77: 181-5
56. Bone I, Rosen M. Alzheimer's disease and anaesthesia. Anaesthesia 2000; 55: 592-3
57. Bohnen NI, Warner MA, Kokmen E, et al. Alzheimer's disease and cumulative exposure to anesthesia: a case-control study. J Am Geriatr Soc 1994; 42: 198-201
58. Gasparini M, Vanacore N, Schiaffini C, et al. A case-control study on Alzheimer's disease and exposure to anesthesia. Neurol Sci 2002; 23: 11-4
59. Parikh SS, Chung F. Postoperative delirium in the elderly. Anesth Analg 1995; 80: 1223-32
60. Hanning CD, Blokland A, Johnson M, et al. Effects of repeated anaesthesia on central cholinergic function in elderly rats [abstract]. Br J Anaesth 2000; 85: 641P
61. Muravchick S, Smith DS. Parkinsonian symptoms during emergence from general anesthesia. Anesthesiology 1995; 82: 305-7
62. Hutchinson RC, Sugden JC. Anaesthesia for Shy-Drager syndrome. Anaesthesia 1984; 39: 1229-31
63. Vincken WG, Gauthier SG, Dollfuss RE, et al. Involvement of upper-airway muscles in extrapyramidal disorders: a cause of airflow limitation. N Engl J Med 1984; 311: 438-42
64. Easdown LJ, Tessler MJ, Minuk J. Upper airway involvement in Parkinson's disease resulting in postoperative respiratory failure. Can J Anaesth 1995; 42: 344-7
65. Wada H, Nakajoh K, Satoh-Nakagawa T, et al. Risk factors of aspiration pneumonia in Alzheimer's disease patients. Gerontology 2001; 47: 271-6
66. Kobayashi H, Nakagawa T, Sekizawa K, et al. Levodopa and swallowing reflex. Lancet 1996; 348: 1320-1
67. Gustafson Y, Brännström B, Norberg A, et al. Underdiagnosis and poor documentation of acute confusional states in elderly hip fracture patients. J Am Geriatr Soc 1991; 39: 760-5
68. Rasmussen LS, Steentoft A, Kristensen PA, et al. Benzodiazepines and postoperative cognitive dysfunction in the elderly. Br J Anaesth 1999; 83: 585-9
69. Pain L, Jeltsch H, Lehmann O, et al. Central cholinergic depletion induced by 192 IgG-saporin alleviates the sedative effects of propofol in rats. Br J Anaesth 2000; 85: 869-73
70. Krauss JK, Akeyson EW, Giam P, et al. Propofol-induced dyskinesias in Parkinson's disease. Anesth Analg 1996; 83: 420-2
71. Anderson BJ, Marks PV, Futter ME. Propofol: contrasting effects in movement disorders. Br J Neurosurg 1994; 8: 387-8
72. Mantz J, Varlet C, Lecharny J-B, et al. Effects of volatile anesthetics, thiopental, and ketamine on spontaneous and depolarization-evoked dopamine release from striatal synaptosomes in the rat. Anesthesiology 1994; 80: 352-63
73. Mackenzie N, Grant IS. Comparison of the new emulsion formulation of propofol with methohexitone and thiopentone for induction of anaesthesia in day cases. Br J Anaesth 1985; 57 (8): 725-31
74. Hetherington A, Rosenblatt RM. Ketamine and paralysis agitans [letter]. Anesthesiology 1980; 52: 527
75. Conzen P, Peter K. Inhalational anaesthesia at the extremes of age: geriatric anaesthesia. Anaesthesia 1995; 50 Suppl.: 29-33S
76. Gravlee GP. Succinylcholine-induced hyperkalemia in a patient with Parkinson's disease. Anesth Analg 1980; 59: 444-6
77. Muzzi DA, Black S, Cucchiara RF. The lack of effect of succinylcholine on serum potassium in patients with Parkinson's disease [letter]. Anesthesiology 1989; 71: 322
78. Wali FA. Myorelaxant effect of diazepam: interactions with neuromuscular blocking agents and cholinergic drugs. Acta Anaesthesiol Scand 1985; 29: 785-9
79. Driessen JJ, Vree TB, van Egmond J, et al. Interaction of midazolam with two non-depolarising neuromuscular blocking drugs in the rat in vivo sciatic nerve-tibialis anterior muscle preparation. Br J Anaesth 1985; 57: 1089-94
80. Driessen JJ, Crul JF, Vree TB, et al. Benzodiazepines and neuromuscular blocking drugs in patients. Acta Anaesthesiol 1986; 30: 642-6
81. Mets B. Acute dystonia after alfentanil in untreated Parkinson's disease. Anesth Analg 1991; 72: 557-8
82. Berg D, Becker G, Reiners K. Reduction of dyskinesia and induction of akinesia induced by morphine in two Parkinsonian patients with severe sciatica. J Neural Transm 1999; 106: 725-8
83. Zomberg GL, Bodkin JA, Cohen BM. Severe adverse interaction between pethidine and selegiline [letter]. Lancet 1991; 337: 246
84. Fischer SP, Mantin R, Brock-Utne JG. Ketorolac and propofol anesthesia in a patient taking chronic monamine oxidase inhibitors. J Clin Anesth 1996; 8: 245-7
85. Tune LE, Damlouji NF, Holland A, et al. Association of postoperative delirium with raised serum levels of anticholinergic drugs. Lancet 1981; II: 651-3
86. Miller PS, Richardson JS, Jyu CA, et al. Association of low serum anticholinergic levels and cognitive impairment in elderly presurgical patients. Am J Psychiatry 1988; 145: 342-5
87. Smith DS, Orkin FK, Gardner SM, et al. Prolonged sedation in the elderly after intraoperative atropine administration. Anesthesiology 1979; 51: 348-9
88. Sheref SE. Pattern of CNS recovery following reversal of neuromuscular blockade: comparison of atropine and glycopyrrolate. Br J Anaesth 1985; 57: 188-91
89. Furuya R, Hirai A, Andoh T, et al. Successful perioperative management of a patient with Parkinson's disease by enteral Levodopa administration under propofol anesthesia. Anesthesiology 1998; 89: 261-3
90. Chung FF, Chung A, Meier RH, et al. Comparison of perioperative mental function after general anaesthesia and spinal anaesthesia with intra-venous sedation. Can J Anaesth 1989; 36: 382-7
91. Crul BJP, Hulstijn W, Burger IC. Influence of the type of anaesthesia on post-operative subjective physical well-being and mental function in elderly patients. Acta Anaesthesiol Scand 1992; 36: 615-20
92. Neilson WR, Gelb AW, Casey JE, et al. Long-term cognitive and social sequelae of general versus regional anesthesia during arthroplasty in the elderly. Anesthesiology 1990; 73: 1103-9
93. Williams-Russo P, Sharrock NE, Mattis S, et al. Cognitive effects after epidural vs general anesthesia in older adults: a randomised trial. JAMA 1995; 274: 44-50
94. Berggren D, Gustafson Y, Eriksson B, et al. Postoperative confusion after anesthesia in elderly patients with femoral neck fractures. Anesth Analg 1987; 66: 497-504
95. Reed AP, Han DG. Intraoperative exacerbation of Parkinson's disease. Anesth Analg 1992; 75: 850-3
96. Bedford PD. Adverse cerebral effects of anaesthesia on old people. Lancet 1955; II: 259-63
97. Gustafson Y, Berggren D, Brännström B, et al. Acute confusional states in elderly patients treated for femoral neck fracture. J Am Geriatr Soc 1988; 36: 525-30
98. O'Keeffe ST, Chonchubhair AN. Postoperative delirium in the elderly. Br J Anaesth 1994; 73: 673-87
99. Golden WE, Lavender RC, Metzer WS. Acute postoperative confusion and hallucinations in Parkinson disease. Ann Intern Med 1989; 111: 218-22
100. Levkoff SE, Evans DA, Liptzin B, et al. Delirium: the occurrence and persistence of symptoms among elderly hospitalized patients. Arch Intern Med 1992; 152: 334-40
101. Dijkstra JB, Houx PJ, Jolles J. Cognition after major surgery in the elderly: test performance and complaints. Br J Anaesth 1999; 82: 867-74
102. Ancelin M-L, de Roquefeuil G, Ledésert B, et al. Exposure to anaesthetic agents, cognitive functioning and depressive symptomatology in the elderly. Br J Psychiatry 2001; 178: 360-6
103. Moller JT, Cluitmans P, Rasmussen LS, et al. Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study. Lancet 1998; 351: 857-61
104. Gustafson Y, Brännstöm B, Berggren D, et al. A geriatric-anesthesiologic program to reduce acute confusional states in elderly patients treated for femoral neck fractures. J Am Geriatr Soc 1991; 39: 655-62
105. Gualandi W, Bonfanti G. A case of prolonged apnoea in Huntington's chorea. Acta Anaesthesiol 1968; 19: 235-8
106. Davies DD. Abnormal response to anaesthesia in a case of Huntington's chorea. Br J Anaesth 1966; 38: 490-1
107. Rodrigo MRC. Huntington's chorea: midazolam, a suitable induction agent? Br J Anaesth 1987; 59: 388-9
108. Leng CP, Gupta K. Huntington' s chorea. Br J Anaesth 2001; 86: 154-5
109. Nagele P, Hammerle AF. Sevoflurane and mivacurium in a patient with Huntington's chorea. Br J Anaesth 2000; 85: 320-1
110. Jin F, Chung F. Minimizing perioperative adverse events in the elderly. Br J Anaesth 2001; 87: 608-24