Multidimensional separation and hyphenated techniques in pharmaceutical research: Practical considerations

Drug Discovery Today

Volumn 9, Issue 7, 2004, Pages 305-306

  Cheng, Xueheng ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Chemical Biology; Drug Discovery; Hyphenated techniques; Liquid chromatography; Mass spectrometry; Multidimensional separations; Pharmaceutical Science; Pharmaceuticals; Techniques Methods

Indexed keywords

ANALYTIC METHOD; EVAPORATION; INFORMATION; LIGHT SCATTERING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEDICAL RESEARCH; NOTE; ONLINE ANALYSIS; SAMPLING; SEPARATION TECHNIQUE; ULTRAVIOLET RADIATION;

DRUG EVALUATION, PRECLINICAL; INFORMATION THEORY; PHARMACEUTICAL PREPARATIONS; PHARMACOLOGY;

EID: 1642358356     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(04)03024-7     Document Type: Note

References (6)

1. Guttman A., et al. Multidimensional separations in the pharmaceutical arena. Drug Disc. Today. 9:2004;136-144.
2. Link A.J., et al. Direct analysis of protein complexes using mass spectrometry. Nature Biotechnol. 17:1997;676-682.
3. Lipton M.S., et al. Global analysis of the Deinococcus radiodurans proteome by using accurate mass tags. Proc. Natl. Acad. Sci. U. S. A. 99:2002;11049-11054.
4. Cheng X., Hochlowski J. Current application of mass spectrometry to combinatorial chemistry. Anal. Chem. 74:2002;2679-2690.
5. Yurek D.A., et al. Development of a system to evaluate compound identity, purity, and concentration in a single experiment and its application in quality assessment of combinatorial libraries and screening hits. J. Comb. Chem. 4:2002;138-148.
6. Cheng X., et al. Studies on repository compound stability in DMSO under various conditions. J. Biomolecular Screening. 8:2003;292-304.