Studies on repository compound stability in DMSO under various conditions

Journal of Biomolecular Screening

Volumn 8, Issue 3, 2003, Pages 292-304

  Cheng, Xueheng ^a   Hochlowski, Jill ^a   Tang, Hua ^a   Hepp, Darlene ^a   Beckner, Carl ^a   Kantor, Stan ^a   Schmitt, Robert ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Compound decomposition; DMSO; Freeze thaw; High throughput screening; Liquid chromatography ultraviolet spectroscopy mass spectrometry (LC UV MS); Repository compound stability

Indexed keywords

DIMETHYL SULFOXIDE; FUNCTIONAL GROUP; GLASS; NITROGEN; OXYGEN; POLYPROPYLENE; WATER; CRYOPROTECTIVE AGENT; SOLVENT;

ARTICLE; CONTAINER; DECOMPOSITION; DRUG STABILITY; FREEZE THAWING; HIGH THROUGHPUT SCREENING; LIGHT SCATTERING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STORAGE; ULTRAVIOLET SPECTROSCOPY; CHEMICAL MODEL; CHEMISTRY; DOSE RESPONSE; DRUG STORAGE; FREEZING; LABORATORY DIAGNOSIS; METHODOLOGY; TEMPERATURE; TIME; ULTRAVIOLET RADIATION;

CHROMATOGRAPHY, LIQUID; CRYOPROTECTIVE AGENTS; DIMETHYL SULFOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; DRUG STORAGE; FREEZING; GLASS; MASS SPECTROMETRY; MODELS, CHEMICAL; OXYGEN; POLYPROPYLENES; SOLVENTS; SPECIMEN HANDLING; TEMPERATURE; TIME FACTORS; ULTRAVIOLET RAYS; WATER;

EID: 0842295942     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1177/1087057103008003007     Document Type: Article

References (24)

1. Dulery BD, Verne-Mismer J, Wolf E, Kugel C, Hijfte LV: Analyses of compound libraries obtained by high-throughput parallel synthesis: strategy of quality control by high-performance liquid chromatography, mass spectrometry and nuclear magnetic resonance techniques. J Chromat B 1999;725:39-47.
2. Yurek DA, Branch DL, Kuo M-S: Development of a system to evaluate compound identity, purity, and concentration in a single experiment and its application in quality assessment of combinatorial libraries and screening hits. J Comb Chem 2002;4:138-148.
3. Darvas F, Karancsi T, Siegel P, Dorman G: Estimating stability for HTS library compounds. Genet Eng News 2000;7:30-31.
4. Darvas F, Dorman G, Karansci T, Nagy T, Bagyi I: Estimation of stability and shelf life for compounds, libraries and repositories in combination with systematic discovery of new rearrrangement pathways. In Nicolaou K, Hanko R, Hartwig W (eds): Handbook of Combinatorial Chemistry. New York: Wiley-VCH, 2002:806-828.
5. Milgram KE, Greig MJ: Assessing the stability of combinatorial libraries stored in frozen DMSO. In Proceedings of 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, CA, June 2000.
6. Heaton Z, Holland S, Hughes R, Lifely R, Robb L: The effect of freeze thawing and storage time on degradation of compounds at 4°C under humidity control using experimental design. Paper presented at the Society for Biomolecular Screening Conference, Baltimore, MD, September 2001.
7. Nelson S: Stability of compounds stored in DMSO. Paper presented at the Society for Biomolecular Screening Conference, Baltimore, MD, September 2001.
8. Williams LE, Kozikowski BA, Burt T, Morand K: High throughput screening degradation study: determination of storage options and retention limits. Paper presented at the Society for Biomolecular Screening Conference, Baltimore, MD, September 2001.
9. Kozikowski BA, Williams LE, Tirey D, Kuzmak B, Morand K: The effect of freeze/thaw cycles on the stability of compounds in DMSO. Paper presented at the Society for Biomolecular Screening Conference, Baltimore, MD, September 2001.
10. Kelley JA, Lai CC, Barchi JJ, Nicklaus MC, Voigt JH, Anderson L, et al: Targeted analytical evaluation of a large small molecule chemical database. In Proceedings of 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, June 2000.
11. Yan B: An evaluation of the stability of purified combinatorial libraries. Paper presented at the post-Drug Discovery Technology 2002 session on Repository Compound Stability Studies, Boston, August 2002.
12. Yaskanin D: Quality perspectives for compound storage. Paper presented at the post-Drug Discovery Technology 2002 session on Repository Compound Stability Studies, Boston, August 2002.
13. Warhurst J: Achieving compound library stability in a real-world HTS environment. Paper presented at the post-Drug Discovery Technology 2002 session on Repository Compound Stability Studies, Boston, August 2002.
14. Turmel M: Compound stability under various storage conditions. Paper presented at the post-Drug Discovery Technology 2002 session on Repository Compound Stability Studies, Boston, August 2002.
15. Savchuk N: Comparative stability of small molecules under a variety of storage and handling conditions. Paper presented at the post-Drug Discovery Technology 2002 session on Repository Compound Stability Studies, Boston, August 2002.
16. Food and Drug Administration: Guideline for Submitting Documentation for the Stability of Human Drugs and Biologies. Rockville, MD: Food and Drug Administration, DHHS, February 1990.
17. Lants RJ Jr: Stability aspects of clinical supplies and scale-up studies. Drug Div Ind Pharm 1984;10:1425-1432.
18. Monkhouse DC: Stability aspects of preformulation and formulation of solid pharmaceuticals. Drug Dev Ind Pharm 1984;10:1373-1412.
19. Stanaszek WF, Pan I-H: Comparison of drug stability in glass versus plastic containers: analysis of prefilled syringe admixtures. Proc Okla Acad Sci 1978;58:102-105.
20. Buko A: Stability testing of chemical diversity in liquid DMSO storage. Paper presented at the American Chemical Society National Meeting, Chicago, August 2001.
21. Cheng X: Studies on compound stability in DMSO under different conditions. Paper presented at the post-Drug Discovery Technology 2002 Session on Repository Compound Stability Studies, Boston, August 2002.
22. Kennon L: Use of models in determining chemical pharmaceutical stability. J Pharm Sci 1964;53(7):815-818.
23. Kommanaboyina B, Roodes CT: Trends in stability testing, with emphasis on stability during distribution and storage. Drug Div Ind Pharm 1999;25 (7):857-868.
24. Anderson G, Scott M: Determination of product shelf life and activation energy for five drugs of abuse. Clin Chem 1991;37(3):398-402.