Pharmacological differentiation of the P2X7 receptor and the maitotoxin-activated cationic channel

European Journal of Pharmacology

Volumn 487, Issue 1-3, 2004, Pages 17-28

  Lundy, Paul M ^a   Nelson, Peggy ^a   Mi, Lei ^b   Frew, Robert ^a   Minaker, Sean ^a   Vair, Cory ^a   Sawyer, Thomas W ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT CANADA   (Canada)

^b Kinchyle Enterprises Inc   (Canada)

Author keywords

ATP P2X7 receptor; Ca 2+; Cell death; Cytolytic pore; Maitotoxin

Indexed keywords

ADENOSINE TRIPHOSPHATE DERIVATIVE; CALCIUM; ETHIDIUM BROMIDE; MAITOTOXIN; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; PURINE P2X7 RECEPTOR; RECEPTOR ANTIBODY; RECEPTOR SUBTYPE; 3' O (4 BENZOYL)BENZOYLADENOSINE 5' TRIPHOSPHATE; 3'-O-(4-BENZOYL)BENZOYLADENOSINE 5'-TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; BUFFER; CALMODULIN; CATION; DRUG DERIVATIVE; ENZYME INHIBITOR; ETHIDIUM; ION CHANNEL; MARINE TOXIN; OXOCIN DERIVATIVE; PURINE P2 RECEPTOR; SULFONAMIDE;

ANIMAL CELL; ARTICLE; CELL DEATH; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG UPTAKE; EXTRACELLULAR CALCIUM; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; ANIMAL; BIOSYNTHESIS; CELL SURVIVAL; CHO CELL; DRUG ANTAGONISM; DRUG EFFECT; HAMSTER; METABOLISM;

ADENOSINE TRIPHOSPHATE; ANIMALS; BUFFERS; CALMODULIN; CATIONS; CELL SURVIVAL; CHO CELLS; CRICETINAE; ENZYME INHIBITORS; ETHIDIUM; ION CHANNELS; MARINE TOXINS; OXOCINS; RECEPTORS, PURINERGIC P2; SULFONAMIDES;

EID: 1642332342     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.01.010     Document Type: Article

References (34)

1. 7 agonist or to maitotoxin. Cell. Signal. 13:2001;465-473.
2. Brake A.J., Wagenbach M.J., Julius D. New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature. 371:1994;519-523.
3. Burnstock G. Current status of purinergic signalling in the nervous system. Illes P., Zimmerman H. Progress in Brain Research. 120, Nucleotides and their Receptors in the Nervous System. 1999;3-10 Elsevier, Amsterdam.
4. 7 receptor-dependent apoptosis of dentritic cells. Am. J. Physiol. 276:1999;C1139-C1147.
5. 2+-channel blockers. Biochem. Pharmacol. 50:1995;1187-1197.
6. 7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems. J. Neurosci. 15:2001;7143-7152.
7. Di Virgilio F. The P2 purinoceptor: an intriguing role in immunity inflammation and cell death. Immunol. Today. 16:1995;524-528.
8. 2-purinergic receptors for extracellular ATP and other nucleotides. Am. J. Physiol. 265:1993;C577-C606.
9. Escobar L.I., Salvador C., Martinez M., Vaca L. Maitotoxin, a cationic channel activator. Neurobiology. 6:1998;59-74.
10. Estacion M., Schilling W.P. Maitotoxin-induced membrane blebbing and cell death in bovine aortic endothelial cells. BMC Physiol. 1:2001;2.
11. 7 nucleotide receptor and associated phospholipase D activity by lipopolysaccharide and IFN-γ in the human THP-1 monocyte cell line. J. Immunol. 157:1996;5627-5637.
12. Humphreys B.D., Rice J., Kertesy S.B., Dubyak G.R. Stress-activated protein kinase/JNK activation and apoptotic induction by the macrophage P2X7 nucleotide receptor. J. Biol. Chem. 275:2000;26792-26798.
13. Kass G.E.N., Orrenius S. Calcium signaling and cytotoxicity. Environ. Health Perspect. 107:1999;25-35.
14. 2+. Toxicol. Appl. Pharmacol. 101:1988;1-10.
15. 7 receptor subtypes. Br. J. Pharmacol. 135:2002;1616-1626.
16. Martinez-Francois J.R., Morales-Tlalpan V., Vaca L. Characterization of the maitotoxin-activated cationic current from human skin fibroblasts. J. Physiol. 538:2002;79-86.
17. 2+ influx. Naunyn-Schmiedeberg's Arch. Pharmacol. 354:1996;562-571.
18. Michel A.D., Chessell I.P., Simon J., Humphrey P.P.A. Identification and characterization of an endogenous P2X7 (P2Z) receptor in CHO-K1 cells. Br. J. Pharmacol. 125:1998;1194-1201.
19. 7 receptor function. Naunyn-Schmiedeberg's Arch. Pharmacol. 359:1999;102-109.
20. Morales-Tlalpan V., Vaca L. Modulation of the maitotoxin response by intracellular and extracellular cations. Toxicon. 40:2002;493-500.
21. Murgia M., Hanau S., Pizzo P., Rippa M., Di Virgilio F. Oxidized ATP, an irreversible inhibitor of the macrophage purinergic P2Z receptor. J. Biol. Chem. 268:1993;8199-8203.
22. Ralevic V., Burnstock G. Receptors for purines and pyrimidines. Pharmacol. Rev. 50:1998;413-492.
23. 7-like cytolytic pore in human skin fibroblasts. Am. J. Physiol. 277:1999;C755-C765.
24. 7 purinergic receptor stimulation activate a common cytolytic pore. Am. J. Physiol. 277:1999;C766-C776.
25. 7 receptors. Am. J. Physiol. 1998;F962-F971.
26. 2Z purinoceptor-associated pores in dibutyryl cyclic AMP-differentiated NG108-15 cells. J. Neurochem. 67:1996;1694-1701.
27. 7). Science. 272:1996;735-737.
28. 2+ levels and membrane potential in purified rat brain synaptosomes. Biochim. Biophys. Acta. 1026:1990;126-132.
29. Valera S., Hussy N., Evans R.J., Adami N., North R.A., Suprenant A., Buell G. A new class of ligand-gated ion channel defined by a P2x receptor for extracellular ATP. Nature. 371:1994;516-519.
30. 7 receptor. Neuropharmacology. 36:1997;1285-1294.
31. 7 receptor. J. Physiol. 519:1999;335-346.
32. Wiley J.S., Chen J.R., Snook M.S., Gargett C.E., Jamieson G.P. Transduction mechanisms of P2Z purinoceptors. P2 Purinoceptors: Localization, Function and Transduction Mechanisms. 1996;149-165 Wiley, Chichester.
33. Zhao X., Pike B.R., Newcomb J.K., Wang K.K.W., Posmantur R.M., Hayes R.L. Maitotoxin induces calpain but not caspase-3 activation and necrotic cell death in primary septo-hippocampal cultures. Neurochem. Res. 24:1999;371-382.
34. Zheng L.M., Zychlinsky A., Liu C.C., Ojcius D.M., Young J.D.-E. Extracellular ATP as a trigger for apoptosis or programmed cell death. J. Cell Biol. 112:1991;279-288.