Meperidine Suppresses the Excitability of Spinal Dorsal Horn Neurons

Anesthesiology

Volumn 100, Issue 4, 2004, Pages 947-955

  Wolff, Matthias ^a,c   Olschewski, Andrea ^b   Vogel, Werner ^b   Hempelmann, Gunter ^a  

^a Intensive Care Medicine   (Germany)

^b Department of Physiology ^*

^c Intensive Care Medicine   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PETHIDINE; POTASSIUM CHANNEL; POTASSIUM ION; SODIUM CHANNEL; SODIUM ION;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; NERVE CELL; NEWBORN; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SODIUM CURRENT; SPINAL CORD DORSAL HORN;

ACTION POTENTIALS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MEPERIDINE; POSTERIOR HORN CELLS; POTASSIUM CHANNELS; RATS; SODIUM CHANNELS;

EID: 1642275281     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200404000-00027     Document Type: Article

References (50)

1. Ngan Kee WD: Intrathecal pethidine: Pharmacology and clinical applications. Anaesth Intensive Care 1998; 26:137-46
2. + channels: Evidence that meperidine is a local anesthetic. ANESTHESIOLOGY 1999; 91:1481-90
3. Mircea N, Constantinescu C, Jianu E, Busu G, Ene C, Daschievici S, Nedelcu A, Leoveanu A: L'anesthésie sousarachnoidienne par la pethidine. Ann Fr Anesth Reanim 1982; 1:167-71
4. Chaudhari LS, Kane DG, Shivkumar B, Kamath SK: Comparative study of intrathecal pethidine versus lignocaine as an anaesthetic and a postoperative analgesic for perianal surgery. J Postgrad Med 1996; 42:43-5
5. Fernandez-Galinski SM, Monells J, Espadaler JM, Pol O, Puig MM: Effects of subarachnoid lidocaine, meperidine and fentanyl on somatosensory and motor evoked responses in awake humans. Acta Anaesthesiol Scand 1996; 40:39-46
6. Grace D, Fee JP: Anaesthesia and adverse effects after intrathecal pethidine hydrochloride for urological surgery. Anaesthesia 1995; 50:1036-40
7. Sia AT, Chow MY, Koay CK, Chong JL: Intrathecal pethidine: An alternative anaesthetic for transurethral resection of prostate? Anaesth Intensive Care 1997; 25:650-4
8. Nguyen Thi TV, Orliaguet G, Ngu TH, Bonnet F: Spinal anesthesia with meperidine as the sole agent for cesarean delivery. Reg Anesth 1994; 19:386-9
9. Acalovschi I, Cristea T: Intravenous regional anesthesia with meperidine. Anesth Analg 1995; 81:539-43
10. Oldroyd GJ, Tham EJ, Power I: An investigation of the local anaesthetic effects of pethidine in volunteers. Anaesthesia 1994; 49:503-6
11. Armstrong PJ, Morton CP, Nimmo AF: Pethidine has a local anaesthetic action on peripheral nerves in vivo: Addition to prilocaine 0.25% for intravenous regional anaesthesia in volunteers. Anaesthesia 1993; 48:382-6
12. Reuben SS, Steinberg RB, Lurie SD, Gibson CS: A dose-response study of intravenous regional anesthesia with meperidine. Anesth Analg 1999; 88:831-5
13. Jaffe RA, Rowe MA: A comparison of the local anesthetic effects of meperidine, fentanyl, and sufentanil on dorsal root axons. Anesth Analg 1996; 83:776-81
14. Frank GB: Two mechanisms for the meperidine block of action potential production in frog's skeletal muscle: Non-specific and opiate drug receptor mediated blockade. J Physiol 1975; 252:585-601
15. Bromage PR, Joyal AC, Binney IC: Local anesthetic drugs: Penetration from the spinal extradural space into the neuraxis. Science 1963; 140:392-4
16. Light AR, Perl ER: Reexamination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of coarse and fine fibers. J Comp Neurol 1979; 186:117-31
17. Light AR, Trevino DL, Perl ER: Morphological features of functionally defined neurons in the marginal zone and substantia gelatinosa of the spinal dorsal horn. J Comp Neurol 1979; 186:151-71
18. + channels in spinal dorsal horn neurones: Role of the soma, axon and dendrites in spike generation. Prog Neurobiol 1999; 59:217-41
19. Famewo CE, Naguib M: Spinal anaesthesia with meperidine as the sole agent. Can Anaesth Soc J 1985; 32:533-7
20. Acalovschi I, Ene V, Lorinczi E, Nicolaus F: Saddle block with pethidine for perineal operations. Br J Anesth 1986; 58:1012-16
21. Nordberg G, Hansdottir V, Bondesson U, Boreus LO, Mellstrand T, Hedner T: CSF and plasma pharmacokinetics of pethidine and norpethidine in man after epidural and intrathecal administration of pethidine. Eur J Clin Pharmacol 1988; 34:625-31
22. Power I, Brown DT, Wildsmith JA: The effect of fentanyl, meperidine and diamorphine on nerve conduction in vitro. Reg Anesth 1991; 16:204-8
23. Kaya K, Babacan A, Beyazova M, Bolukbasi N, Akcabay M, Karadenizli Y: Effects of perineural opioids on nerve conduction of N. suralis in man. Acta Neurol Scand 1992; 85:337-9
24. + channels in amphibian peripheral nerves. ANESTHESIOLOGY 2000; 92:147-55
25. Katchman AN, McGroary KA, Kilborn MJ, Kornick CA, Manfredi PL, Woosley RL, Ebert SN: Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents. J Pharmacol Exp Ther 2002; 303:688-94
26. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Archiv 1981; 391:85-100
27. Edwards FA, Konnerth A, Sakmann B, Takahashi T: A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system. Pflugers Archiv 1989; 414:600-12
28. Takahashi T: Membrane currents in visually identified motoneurones of neonatal rat spinal cord. J Physiol 1990; 423:27-46
29. + channel on soma and processes of dorsal horn neurones of rat spinal cord. J Physiol 1997; 503:371-85
30. + currents by local anesthetics in the dorsal horn neurons of the spinal cord. ANESTHESIOLOGY 1998; 88:172-9
31. D'Angelo R, Anderson MT, Philip J, Eisenach JC: Intrathecal sufentanil compared to epidural bupivacaine for labor analgesia. ANESTHESIOLOGY 1994; 80:1209-15
32. Bion JF: Intrathecal ketamine for war surgery: A preliminary study under field conditions. Anaesthesia 1984; 39:1023-8
33. 2-Adrenergic agonists for regional anesthesia: A clinical review of clonidine (1984-1995). ANESTHESIOLOGY 1996; 85:655-74
34. Patel D, Janardhan Y, Merai B, Robalino J, Shevde K: Comparison of intrathecal meperidine and lidocaine in endoscopic urological procedures. Can J Anaesth 1990; 37:567-70
35. Sangarlangkam S, Klaewtanong V, Jonglerttrakool P, Khankaew V: Meperidine as a spinal anesthetic agent: A comparison with lidocaine-glucose. Anesth Analg 1987; 66:235-40
36. Beyazova M, Babacan A, Bilir E, Akcabay M, Kaya K, Baysal AI: Perineural pethidine: Effects of different doses on nerve conduction. Eur J Anaesthesiol 1993; 10:353-6
37. Hille B: Ion Channels of Excitable Membranes, 3rd edition. Sunderland, Massachusetts, Sinauer Associates, 2001
38. Strichartz GR: The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J Gen Physiol 1973; 62:37-57
39. Courtney KR: Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA. J Pharmacol Exp Ther 1975; 195:225-36
40. Olschewski A, Wolff M, Brau ME, Hempelmann G, Vogel W, Safronov BV: Enhancement of delayed-rectifier potassium conductance by low concentrations of local anaesthetics in spinal sensory neurones. Br J Pharmacol 2002; 136:540-9
41. + channels in peripheral nerve. Anesth Analg 1998; 87:885-9
42. Olschewski A, Hempelmann G, Vogel W, Safronov BV: Suppression of potassium conductance by droperidol has influence on excitability of spinal sensory neurons. ANESTHESIOLOGY 2001; 94:280-9
43. Madeja M: Do neurons have a reserve of sodium channels for the generation of action potentials? A study on acutely isolated CAI neurons from the guinea-pig hippocampus. Eur J Neurosci 2000; 12:1-7
44. + channels in soma, axon and dendrites of rat spinal neurones: Functional role of the soma in generation of action potentials. J Physiol 1998; 509:767-76
45. Hassan HG, Pilcher CW, Akerman B, Renck H: Antinociceptive effects of localized administration of opioids compared with lidocaine. Reg Anesth 1989; 14:138-44
46. Grant GJ, Vermeulen K, Zakowski MI, Langerman L: Perineural antinociceptive effect of opioids in a rat model. Acta Anaesthesiol Scand 2001; 45:906-10
47. Gissen AJ, Gugino LD, Datta S, Miller J, Covino BG: Effects of fentanyl and sufentanil on peripheral mammalian nerves. Anesth Analg 1987; 66:1272-6
48. Tamsen A, Hartvig P, Fagerlund C, Dahlstrom B: Patient-controlled analgesic therapy: II. Individual analgesic demand and analgesic plasma concentrations of pethidine in postoperative pain. Clin Pharmacokinet 1982; 7:164-75
49. Sprigge JS, East DS, Fox GS, Ogilvie RI, Otton PE, Bevan DR: Meperidine infusion for postoperative analgesia in grossly obese patients. Can Anaesth Soc J 1982; 29:142-7
50. Zhou FM, Hablitz JJ: Layer I neurons of rat neocortex: I. Action potential and repetitive firing properties. J Neurophysiol 1996; 76:651-67