Uneven distribution of K+ channels in soma, axon and dendrites of rat spinal neurones: Functional role of the soma in generation of action potentials

Journal of Physiology

Volumn 509, Issue 3, 1998, Pages 767-776

  Wolff, Matthias ^a   Vogel, Werner ^a   Safronov, Boris V ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM ION; VOLTAGE GATED POTASSIUM CHANNEL;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DENDRITE; NERVE EXCITABILITY; NERVE FIBER; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; CELL ISOLATION; CELLULAR DISTRIBUTION; CURRENT CLAMP TECHNIQUE; DELAYED RECTIFIER POTASSIUM CURRENT; EXCITATORY POSTSYNAPTIC POTENTIAL; INACTIVATING POTASSIUM CURRENT; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; NERVE CELL MEMBRANE STEADY POTENTIAL; NEWBORN; PYRAMIDAL NERVE CELL; SODIUM CURRENT; SOMATIC CELL; SPINAL CORD NERVE CELL;

4-AMINOPYRIDINE; ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; AXONS; DENDRITES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; RATS; SODIUM CHANNELS; SPINAL CORD; TETRAETHYLAMMONIUM;

EID: 0032525993     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.767bm.x     Document Type: Article

References (27)

1. ANGELIDES, K. J., ELMER, L. W., LOFTUS, D. & ELSON, E. (1988). Distribution and lateral mobility of voltage-dependent sodium channels in neurons. Journal of Cell Biology 106, 1911 -1925.
2. BLACK, J. A., KOCSIS, J. D. & WAXMAN, S. G. (1990). Ion channel organization of the myelinated fiber. Trends in Neurosciences 13, 48-54.
3. 125I]α-scorpion toxin binding sites on fetal mouse nerve cells in culture. Developmental Brain Research 20, 137-142.
4. CATTERALL, W. A. (1981). Localization of sodium channels in cultured neural cells. Journal of Neuroscience 1, 777-783.
5. + channel densities in the soma and axon initial segment of subicular pyramidal neurons. Journal of Neuroscience 16, 6676-6686.
6. CONNOR, J. A. & STEVENS, C. F. (1971). Prediction of repetitive firing behaviour from voltage clamp data on an isolated neurone soma. Journal of Physiology 213, 31-53.
7. COOMBS, J. S., CURTIS, D. R. & ECOLES, J. C. (1957a). The interpretation of spike potentials of motoneurones. Journal of Physiology 139, 198-231.
8. COOMBS, J. S., CUBTIS, D. R. & ECCLES, J. C. (1957b). The generation of impulses in motoneurones. Journal of Physiology 139, 232-249.
9. ECCLES, J. C. (1964). The Physiology of Synapses. Springer Verlag, Berlin, Göttingen, Heidelberg.
10. EDWARDS, F. A., KONNERTH, A., SAKMANN, B. & TAKAHASHI, T. (1989). A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system. Pflügers Archiv 414, 600-612.
11. HAMILL, O. P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F. J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Archiv 391, 85-100.
12. HILLE, B. (1992). Ionic Channels of Excitable Membranes, 2nd edn. Sinauer Associates, Sunderland.
13. HODGKIN, A. L. & HUXLEY, A. F. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. Journal of Physiology 117, 500-544.
14. + channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature 387, 869-875.
15. HUGUENARD, J. R., HAMILL, O. P. & PRINCE, D. A. (1989). Sodium channels in dendrites of rat pyramidal neurons. Proceedings of the National Academy of Sciences of the USA 86, 2473-2477.
16. JOHNSTON, D., MAGEE, J. C., COLBERT, C. M. & CHRISTIE, B. R. (1996). Active properties of neuronal dendrites. Annual Review of Neuroscience. 19, 165-186.
17. LLINAS, R. R. (1988). The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science 242, 1654-1664.
18. 2+ channels in apical dendrites of rat CA1 pyramidal neurons. Journal of Physiology 487, 67-90.
19. + channels in the somata of rat motoneurones. Journal of Physiology 487, 91-106.
20. + channel on soma and processes of dorsal horn neurones of rat spinal cord. Journal of Physiology 503, 371-385.
21. SAKMANN, B. & NEHER, E. (1995). Geometric parameters of pipettes and membrane patches. In Single-Channel Recording, 2nd edn, ed. SAKMANN, B. & NEHER, E. Plenum Press, New York.
22. SCHWINDT, P. C. & CRILL, W. E. (1995). Amplification of synaptic current by persistent sodium conductance in apical dendrite of neocortical neurons. Journal of Neurophysiology 74, 2220-2224.
23. STUART, G. J., DODT, H.-U. & SAKMANN, B. (1993). Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy. Pflügers Archiv 423, 511-518.
24. STUART, G. J. & SAKMANN, B. (1994). Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature 367, 69-72.
25. STUABT, G. J. & SAKMANN, B. (1995). Amplification of EPSPs by axosomatic sodium channels in neocortical pyramidal neurons. Neuron 15, 1065-1076.
26. TAKAHASHI, T. (1990). Membrane currents in visually identified motoneurones of neonatal rat spinal cord. Journal of Physiology 423, 27-46.
27. WOLLNER, D. A. & CATTEEALL, W. A. (1986). Localization of sodium channels in axon hillocks and initial segments of retinal ganglion cells. Proceedings of the National Academy of Sciences of the USA 83, 8424-8428.