Do neurons have a reserve of sodium channels for the generation of action potentials? A study on acutely isolated CA1 neurons from the guinea-pig hippocampus

European Journal of Neuroscience

Volumn 12, Issue 1, 2000, Pages 1-7

  Madeja, Michael ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Density of channels; Frequency; Recovery; Repetitive firing; Tetrodotoxin

Indexed keywords

SODIUM; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN NERVE CELL; CHANNEL GATING; CONTROLLED STUDY; DEMYELINATING DISEASE; GUINEA PIG; HIPPOCAMPUS; NERVE CELL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; VOLTAGE CLAMP;

ACTION POTENTIALS; ANIMALS; GUINEA PIGS; HIPPOCAMPUS; NEURONS; PATCH-CLAMP TECHNIQUES; SODIUM CHANNELS; TETRODOTOXIN;

EID: 0033959111     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00871.x     Document Type: Article

References (29)

1. Bezanilla, F. & Armstrong, C.M. (1977) Inactivation of the sodium channel. I. Sodium current experiments. J. Gen. Physiol., 70, 549-566.
2. Black, J.A., Kocsis, J.D. & Waxman, S.G. (1990) Ion channel organization of the myelinated fiber. Trends Neurosci., 13, 48-54.
3. Catterall, W.A. (1980) Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Annu. Rev. Pharmacol. Toxicol., 20, 15-43.
4. Catterall, W.A. (1992) Cellular and molecular biology of voltage-gated sodium channels. Physiol. Rev., 72, S15-S48.
5. Chiu, S.Y. (1980) Asymmetry currents in the mammalian myelinated nerve. J. Physiol. (Lond.), 273, 499-519.
6. Colino, A., Garcia-Seoane, J.J. & Valentin, A. (1998) Action potential broadening induced by lithium may cause a presynaptic enhancement of excitatory synaptic transmission in neonatal rat hippocampus. Eur. J. Neurosci., 10, 2433-2443.
7. Conti, F., Hille, B., Neumcke, B., Nonner, W. & Stämpfli, R. (1976) Measurement of the conductance of the sodium channel from current fluctuations at the node of Ranvier. J. Physiol. (Lond.), 262, 699-727.
8. Costa, P.F. (1996) The kinetic parameters of sodium currents in maturing acutely isolated rat hippocampal CA1 neurones. Dev. Brain Res., 91, 29-40.
9. Figenschou, A., Guo-Yuan, H. & Storm, J.F. (1996) Cholinergic modulation of the action potential in rat hippocampal neurons. Eur. J. Neurosci., 8, 211-219.
10. Francke, M., Pannicke, T., Biedermann, B., Faude, F. & Reichelt, W. (1996) Sodium current amplitude increases dramatically in human retinal glial cells during diseases of the eye. Eur. J. Neurosci., 8, 2662-2670.
11. Hamill, O.P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F.J. (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch., 391, 85-100.
12. Hille, B. (1992) Counting channels. In Editors? (eds), Ionic Channels of Excitable Membranes, 2nd ed., Chapter 12. Sinauer Associates, Sunderland, MA, USA, pp. 315-336.
13. Kandel, E.R. (1976) Cellular mechanisms of neuronal function. In Kandel, E.R. (ed.), Cellular Basis of Behavior, Chapter 6. Freeman, San Francisco, pp. 137-210.
14. Kay, A.R. & Wong, R.K.S. (1986) Isolation of neurons suitable for patch-clamping from adult mammalian central nervous systems. J. Neurosci. Meth., 16, 227-238.
15. Kocsis, J.D. & Waxman, S.G. (1985) Demyelination: causes and mechanisms of clinical abnormality and functional recovery. In Koetsier, J.C. (ed.), Handbook of Clinical Neurology, Vol. 3, Demyelinating Diseases. Elsevier Science, Amsterdam, pp. 29-47.
16. 2+ on delayed-rectifier potassium channels in acutely isolated hippocampal neurons. J. Neurophysiol., 78, 2649-2654.
17. 2+ channels in apical dendrites of rat CA1 pyramidal neurons. J. Physiol. (Lond.), 487, 67-90.
18. Magistretti, J., Mantegazza, M., Guatteo, E. & Wanke, E. (1996) Action potentials recorded with patch-clamp amplifiers: are they genuine? Trends Neurosci., 19, 530-534.
19. + channels identified by high-affinity receptors for tetrodotoxin and saxitoxin in rat and human brains: quantitative autoradiographic analysis. Brain Res., 448, 128-139.
20. Narahashi, T. (1974) Chemicals as tools in the study of excitable membranes. Physiol. Rev., 54, 813-889.
21. Ritchie, J.M. & Rogart, R.B. (1977) The density of sodium channels in mammalian myelinated nerve fibers and the nature of the axonal membrane under the myelin sheath. Proc. Natl Acad. Sci. USA, 74, 211-215.
22. Sah, P., Gibb, A.J. & Gage, P.W. (1988) The sodium current underlying action potentials in guinea pig hippocampal CA1 neurons. J. Gen. Physiol., 91, 373-398.
23. Safronov, B.V., Wolff, M. & Vogel, W. (1999) Axonal expression of sodium channels in rat spinal neurones during postnatal development. J. Physiol. (Lond.), 514, 729-734.
24. + channel in rat dorsal root ganglion neurons and their blockade by halothane. Eur. J. Neurosci., 10, 2547-2556.
25. Schwarz, J.R., Ulbricht, W. & Wagner, H.-H. (1973) The rate of action of tetrodotoxin on myelinated nerve fibres of Xenopus laevis and Rana esculenta. J. Physiol. (Lond.), 233, 167-194.
26. 3 areas of the hippocampus of postnatal rats. Pflügers Arch., 415, 756-761.
27. Ulbricht, W. (1981) Kinetics of drug action and equilibrium. Results at the node of Ranvier. Physiol. Rev., 61, 785-828.
28. Vreugdenhil, M. & Wadman, W.J. (1995) Potassium currents in isolated CA1 neurons of the rat after kindling epileptogenesis. Neuroscience, 66, 805-813.
29. Waxman, S.G. & Ritchie, J.M. (1985) Organization of ion channels in myelinated nerve fiber. Science, 228, 1502-1507.