Lack of association of human G-protein β3 subunit variant with hypertension in Japanese workers

Journal of Hypertension

Volumn 22, Issue 3, 2004, Pages 493-500

  Suwazono, Yasushi ^a   Okubo, Yasushi ^a   Kobayashi, Etsuko ^a   Miura, Katsuyuki ^b   Morikawa, Yuko ^b   Ishizaki, Masao ^b   Kido, Teruhiko ^c   Nakagawa, Hideaki ^b   Nogawa, Koji ^a  

^a CHIBA UNIVERSITY   (Japan)

^b KANAZAWA MEDICAL UNIVERSITY   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

Author keywords

G proteins; Genetics; Hypertension; Japanese; Polymorphism; Population

Indexed keywords

ANTIHYPERTENSIVE AGENT; GAMMA GLUTAMYLTRANSFERASE; GUANINE NUCLEOTIDE BINDING PROTEIN; URIC ACID;

AGE; ANTIHYPERTENSIVE THERAPY; ARTICLE; BLOOD CHEMISTRY; BLOOD PRESSURE; BODY MASS; CAUCASIAN; CONTROLLED STUDY; DATA ANALYSIS; DIASTOLIC BLOOD PRESSURE; FAMILY HISTORY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HEMATOCRIT; HUMAN; HYPERTENSION; JAPAN; LIFESTYLE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MULTIPLE REGRESSION; PRIORITY JOURNAL; SEX DIFFERENCE; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE COUNT;

EID: 1642269899     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200403000-00011     Document Type: Article

References (21)

1. Siffert W, Rosskopf D, Siffert G, Busch S, Moritz A, Erbel R, et al. Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet 1998; 18:45-48.
2. Siffert W, Forster P, Jockel KH, Mvere DA, Brinkmann B, Naber C, et al. Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol 1999; 10:1921-1930.
3. Schunkert H, Hense HW, Doring A, Riegger GA, Siffert W. Association between a polymorphism in the G protein beta3 subunit gene and lower renin and elevated diastolic blood pressure levels. Hypertension 1998; 32:510-513.
4. Benjafield AV, Jeyasingam CL, Nyholt DR, Griffiths LR, Morris BJ. G-protein beta3 subunit gene (GNB3) variant in causation of essential hypertension. Hypertension 1998; 32:1094-1097.
5. Beige J, Hohenbleicher H, Distler A, Sharma AM. G-Protein beta3 subunit C825T variant and ambulatory blood pressure in essential hypertension. Hypertension 1999; 33:1049-1051.
6. Hengstenberg C, Schunkert H, Mayer B, Doring A, Lowel H, Hense HW, et al. Association between a polymorphism in the G protein beta3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction. Cardiovasc Res 2001; 49:820-827.
7. Dong Y, Zhu H, Sagnella GA, Carter ND, Cook DG, Cappuccio FP. Association between the C825T polymorphism of the G protein beta3-subunit gene and hypertension in blacks. Hypertension 1999; 34: 1193-1196.
8. Brand E, Herrmann SM, Nicaud V, Ruidavets JB, Evans A, Arveiler D, et al. The 825C/T polymorphism of the G-protein subunit beta3 is not related to hypertension. Hypertension 1999; 33:1175-1178.
9. Larson N, Hutchinson R, Boerwinkle E. Lack of association of 3 functional gene variants with hypertension in African Americans. Hypertension 2000; 35:1297-1300.
10. Tsai CH, Yeh HI, Chou Y, Liu HF, Yang TY, Wang JC, et al. G protein beta3 subunit variant and essential hypertension in Taiwan - a case-control study. Int J Cardiol 2000; 73:191-195, 197.
11. Snapir A, Heinonen P, Tuomainen TP, Lakka TA, Kauhanen J, Salonen JT, et al. G-protein beta3 subunit C825T polymorphism: no association with risk for hypertension and obesity. J Hypertens 2001; 19:2149-2155.
12. Hegele RA, Harris SB, Hanley AJ, Cao H, Zinman B. G protein beta3 subunit gene variant and blood pressure variation in Canadian Oji-Cree. Hypertension 1998; 32:688-692.
13. Tozawa Y. G protein beta3 subunit variant: tendency of increasing susceptibility to hypertension in Japanese. Blood Press 2001; 10: 131-134.
14. Izawa H, Yamada Y, Okada T, Tanaka M, Hirayama H, Yokota M. Prediction of genetic risk for hypertension. Hypertension 2003; 41:1035-1040.
15. Kato N, Sugiyama T, Morita H, Kurihara H, Yamori Y, Yazaki Y. G protein beta3 subunit variant and essential hypertension in Japanese. Hypertension 1998; 32:935-938.
16. Ishikawa K, Imai Y, Katsuya T, Ohkubo T, Tsuji I, Nagai K, et al. Human G-protein beta3 subunit variant is associated with serum potassium and total cholesterol levels but not with blood pressure. Am J Hypertens 2000; 13:140-145.
17. Nishimura N, Nakayama T, Tonoike H, Kojima K, Shirasaki Y, Kondoh K, et al. Various applications of direct PCR using blood samples. Clin Lab 2002; 48:377-384.
18. Buchmayer H, Sunder-Plassmann G, Hirschl MM, Kletzmayr J, Woisetschlager C, Laggner AN, et al. G-protein beta3 subunit gene (GNB3) polymorphism 825C→T in patients with hypertensive crisis. Crit Care Med 2000; 28:3203-3206.
19. Rosskopf D, Busch S, Manthey I, Siffert W. G protein beta 3 gene: structure, promoter, and additional polymorphisms. Hypertension 2000; 36:33-41.
20. Rosskopf D, Manthey I, Siffert W. Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit. Pharmacogenetics 2002; 12:209-220.
21. Siffert W. G-protein beta3 subunit 825T allele and hypertension. Curr Hypertens Rep 2003; 5:47-53.