Expression of tau reduces secretion of Aβ without altering the amyloid precursor protein content in CHOsw cells

FEBS Letters

Volumn 579, Issue 10, 2005, Pages 2119-2124

  Zhao, Zhong ^a   Ksiezak Reding, Hanna ^a   Wang, Jun ^a   Pasinetti, Giulio Maria ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Adenovirus; Alzheimer's disease; Amyloid precursor protein; A peptide; Insulin degrading enzyme; Secretase; Tau

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; TAU PROTEIN;

ANIMAL CELL; ARTICLE; CELL AGGREGATION; CELL VACUOLE; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVITY; GOLGI COMPLEX; INSULIN DEGRADATION; MICROTUBULE; MOLECULAR BIOLOGY; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; REDUCTION KINETICS; STEADY STATE;

ADENOVIRIDAE;

EID: 16344395142     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.02.067     Document Type: Article

References (18)

1. M.S. Wolfe APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease Int. Immunopharmacol. 2 2002 1919 1929 Review
2. H. Xu, D. Sweeney, R. Wang, G. Thinakaran, A.C. Lo, S.S. Sisodia, P. Greengard, and S. Gandy Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation Proc. Natl. Acad. Sci. USA 94 1997 3748 3752
3. S. Baulac, M.J. LaVoie, W.T. Kimberly, J. Strahle, M.S. Wolfe, D.J. Selkoe, and W. Xia Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates Neurobiol. Dis. 14 2003 194 204
4. W. Farris, S. Mansourian, Y. Chang, L. Lindsley, E.A. Eckman, M.P. Frosch, C.B. Eckman, R.E. Tanzi, D.J. Selkoe, and S. Guenette Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo Proc. Natl. Acad. Sci. USA 100 2003 4162 4167
5. A. Lleo, O. Berezovska, J.H. Growdon, and B.T. Hyman Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations Am. J. Geriatr. Psychiatry 12 2004 146 156 Review
6. E.M. Mandelkow, K. Stamer, R. Vogel, E. Thies, and E. Mandelkow Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses Neurobiol. Aging 24 2003 1079 1085
7. K. Stamer, R. Vogel, E. Thies, E. Mandelkow, and E.M. Mandelkow Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress J. Cell Biol. 156 2002 1051 1063
8. W. Elyaman, C. Yardin, and J. Hugon Involvement of glycogen synthase kinase-3beta and tau phosphorylation in neuronal Golgi disassembly J. Neurochem. 81 2002 870 880
9. M.E. Figueiredo-Pereira, S. Efthimiopoulos, N. Tezapsidis, A. Buku, J. Ghiso, P. Mehta, and N.K. Robakis Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively J. Neurochem. 72 1999 1417 1422
10. Z. Zhao, L. Ho, J. Suh, W. Qin, H. Pyo, P. Pompl, H. Ksiezak-Reding, and G.M. Pasinetti A role of P301L tau mutant in anti-apoptotic gene expression, cell cycle and apoptosis Mol. Cell. Neurosci. 24 2003 367 379
11. W. Qin, L. Ho, P.N. Pompl, Y. Peng, Z. Zhao, Z. Xiang, N.K. Robakis, J. Shioi, J. Suh, and G.M. Pasinetti Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity J. Biol. Chem. 278 2003 50970 50977
12. A. Perez, L. Morelli, J.C. Cresto, and E.M. Castano Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains Neurochem. Res. 25 2000 247 255
13. J.H. Cho, and G.V. Johnson Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules J. Neurochem. 88 2004 349 358
14. K.S. Vetrivel, H. Cheng, W. Lin, T. Sakurai, T. Li, N. Nukina, P.C. Wong, H. Xu, and G. Thinakaran Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes J. Biol. Chem. 279 2004 44945 44954
15. D.M. Wilcock, A. Rojiani, A. Rosenthal, G. Levkowitz, S. Subbarao, J. Alamed, D. Wilson, N. Wilson, M.J. Freeman, M.N. Gordon, and D. Morgan Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition J. Neurosci. 24 2004 6144 6151
16. M.L. Michaelis, S. Ansar, Y. Chen, E.R. Reiff, K.I. Seyb, R.H. Himes, K.L. Audus, and G.I. Georg β-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents J. Pharmacol. Exp. Ther. 312 2005 659 668
17. H. Ksiezak-Reding, L.I. Binder, and S.-H. Yen Immunochemical and biochemical characterization of tau proteins in normal and Alzheimer's disease brains with Alz 50 and Tau-1 J. Biol. Chem. 263 1988 7948 7953
18. M. Holzer, H.P. Holzapfel, D. Zedlick, M.K. Bruckner, and T. Arendt Abnormally phosphorylated tau protein in Alzheimer's disease: heterogeneity of individual regional distribution and relationship to clinical severity Neuroscience 63 1994 499 516