Defining the physical gate of a mechanosensitive channel, MscL, by engineering metal-binding sites

Biophysical Journal

Volumn 87, Issue 5, 2004, Pages 3172-3180

  Iscla, Irene ^a   Levin, Gal ^a   Wray, Robin ^a   Reynolds, Robert ^a   Blount, Paul ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADMIUM; HISTIDINE; METAL; NICKEL; ZINC; ESCHERICHIA COLI PROTEIN; ION CHANNEL; MSCL PROTEIN, E COLI; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; BIOENGINEERING; CHANNEL GATING; CONDUCTANCE; ESCHERICHIA COLI; MEMBRANE CHANNEL; METAL BINDING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; CHEMISTRY; DRUG EFFECT; GENETICS; MECHANICAL STRESS; MECHANOTRANSDUCTION; METABOLISM; METHODOLOGY; PHYSIOLOGY; PRESSURE; PROTEIN BINDING; PROTEIN ENGINEERING; SITE DIRECTED MUTAGENESIS; SPHEROPLAST; STRUCTURE ACTIVITY RELATION;

ESCHERICHIA COLI; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

BINDING SITES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ION CHANNEL GATING; ION CHANNELS; MECHANOTRANSDUCTION, CELLULAR; METALS; MUTAGENESIS, SITE-DIRECTED; PRESSURE; PROTEIN BINDING; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SPHEROPLASTS; STRESS, MECHANICAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 16344363652     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.104.049833     Document Type: Article

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