A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension

Nature Structural Biology

Volumn 9, Issue 9, 2002, Pages 704-710

  Betanzos, Monica ^a   Chiang, Chien Sung ^a   Guy, H Robert ^b   Sukharev, Sergei ^a  

^a University of Maryland   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CHANNEL PROTEIN; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CROSS LINKING; DISULFIDE BOND; ESCHERICHIA COLI; MEMBRANE CHANNEL; MOLECULAR MODEL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OSMOSIS; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN STRUCTURE;

NASA DISCIPLINE CELL BIOLOGY; NON-NASA CENTER;

ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ION CHANNELS; MODELS, MOLECULAR; MUTAGENESIS; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; NEGIBACTERIA;

EID: 0036728233     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb828     Document Type: Article

References (18)

1. Bacterial mechanosensitive channels: Integrating physiology, structure and function
2. Mechanosensitive channels in bacteria as membrane tension reporters
3. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: Identification of genes required for MscS activity
4. Structure of the MscL homolog from Mycobacterium tuberculosis: A gated mechanosensitive ion channel
5. A large-conductance mechanosensitive channel in E. coli encoded by mscL alone
6. Membrane topology and multimeric structure of a mechanosensitive channel protein of Escherichia coli
7. Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL
8. Functional and structural conservation in the mechanosensitive channel MscL implicates elements crucial for mechano-sensation
9. One face of a transmembrane helix is crucial in mechanosensitive channel gating
10. Hydrophilicity of a single residue within MscL correlates with increased channel mechanosensitivity
11. Correlating a protein structure with function of a bacterial mechanosensitive channel
12. Structural models of the MscL gating mechanism
13. The gating mechanism of the large mechanosensitive channel MscL
14. Single residue substitutions that change the gating properties of a mechanosensitive channel in Escherichia coli
15. Chemically charging the pore constriction opens the mechanosensitive channel MscL
16. The influence of membrane lateral pressures on simple geometric models of protein conformational equilibria
17. Determination of transmembrane protein structure by disulfide cross-linking: The Escherichia coli Tar receptor
18. Pressure-sensitive ion channel in Escherichia coli