Requirement of the coiled-coil domain of PML-RARα oncoprotein for localization, sumoylation, and inhibition of monocyte differentiation

Biochemical and Biophysical Research Communications

Volumn 330, Issue 3, 2005, Pages 746-754

  Kim, Young Eui ^a   Kim, Dong Yeon ^a   Lee, Jang Mi ^a   Kim, Seong Tae ^a   Han, Tae Hee ^a   Ahn, Jin Hyun ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

C EBP ; Coiled coil domain; Differentiation; Localization; Oligomerization; Oncogenesis; PML; PML RAR ; SUMO modification; Transactivation

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; CD14 ANTIGEN; COLECALCIFEROL; DNA; MUTANT PROTEIN; ONCOPROTEIN; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN UBC9; RETINOIC ACID RECEPTOR ALPHA; SUMO PROTEIN; TRANSCRIPTION FACTOR GAL4; UBIQUITIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CONJUGATION; CONTROLLED STUDY; EMBRYO; GENE DELETION; HUMAN; HUMAN CELL; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TRANSACTIVATION;

EID: 16244417803     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.03.052     Document Type: Article

References (43)

1. J. Borrow, A.D. Goddard, D. Sheer, and E. Solomon Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17 Science 249 1990 1577 1580
2. A. Kakizuka, W.H. Miller Jr., K. Umesono, R.P. Warrell Jr., S.R. Frankel, V.V. Murty, E. Dmitrovsky, and R.M. Evans Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML Cell 66 1991 663 674
3. H. de The, C. Chomienne, M. Lanotte, L. Degos, and A. Dejean The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus Nature 347 1990 558 561
4. D. Brown, S. Kogan, E. Lagasse, I. Weissman, M. Alcalay, P.G. Pelicci, S. Atwater, and J.M. Bishop A PMLRARalpha transgene initiates murine acute promyelocytic leukemia Proc. Natl. Acad. Sci. USA 94 1997 2551 2556
5. J.L. Grisolano, R.L. Wesselschmidt, P.G. Pelicci, and T.J. Ley Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences Blood 89 1997 376 387
6. L.Z. He, C. Tribioli, R. Rivi, D. Peruzzi, P.G. Pelicci, V. Soares, G. Cattoretti, and P.P. Pandolfi Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice Proc. Natl. Acad. Sci. USA 94 1997 5302 5307
7. R.J. Lin, D.A. Egan, and R.M. Evans Molecular genetics of acute promyelocytic leukemia Trends Genet. 15 1999 179 184
8. L. Alland, R. Muhle, H. Hou Jr., J. Potes, L. Chin, N. Schreiber-Agus, and R.A. DePinho Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression Nature 387 1997 49 55
9. T. Heinzel, R.M. Lavinsky, T.M. Mullen, M. Soderstrom, C.D. Laherty, J. Torchia, W.M. Yang, G. Brard, S.D. Ngo, J.R. Davie, E. Seto, R.N. Eisenman, D.W. Rose, C.K. Glass, and M.G. Rosenfeld A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression Nature 387 1997 43 48
10. L. Nagy, H.Y. Kao, D. Chakravarti, R.J. Lin, C.A. Hassig, D.E. Ayer, S.L. Schreiber, and R.M. Evans Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase Cell 89 1997 373 380
11. L.P. Freedman Increasing the complexity of coactivation in nuclear receptor signaling Cell 97 1999 5 8
12. L.Z. He, T. Merghoub, and P.P. Pandolfi In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications Oncogene 18 1999 5278 5292
13. A.R. Mistry, E.W. Pedersen, E. Solomon, and D. Grimwade The molecular pathogenesis of acute promyelocytic leukaemia: implications for the clinical management of the disease Blood Rev. 17 2003 71 97
14. K. Jensen, C. Shiels, and P.S. Freemont PML protein isoforms and the RBCC/TRIM motif Oncogene 20 2001 7223 7233
15. T. Sternsdorf, K. Jensen, and H. Will Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1 J. Cell Biol. 139 1997 1621 1634
16. A.M. Ishov, A.G. Sotnikov, D. Negorev, O.V. Vladimirova, N. Neff, T. Kamitani, E.T. Yeh, J.F. Strauss III, and G.G. Maul PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1 J. Cell Biol. 147 1999 221 234
17. V. Lallemand-Breitenbach, J. Zhu, F. Puvion, M. Koken, N. Honore, A. Doubeikovsky, E. Duprez, P.P. Pandolfi, E. Puvion, P. Freemont, and H. de The Role of promyelocytic leukemia (PML) sumoylation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation J. Exp. Med. 193 2001 1361 1371
18. H. Li, and J.D. Chen PML and the oncogenic nuclear domains in regulating transcriptional repression Curr. Opin. Cell Biol. 12 2000 641 644
19. S. Zhong, S. Muller, S. Ronchetti, P.S. Freemont, A. Dejean, and P.P. Pandolfi Role of SUMO-1-modified PML in nuclear body formation Blood 95 2000 2748 2752
20. J.A. Dyck, G.G. Maul, W.H. Miller Jr., J.D. Chen, A. Kakizuka, and R.M. Evans A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein Cell 76 1994 333 343
21. K. Weis, S. Rambaud, C. Lavau, J. Jansen, T. Carvalho, M. Carmo-Fonseca, A. Lamond, and A. Dejean Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells Cell 76 1994 345 356
22. M.H. Koken, F. Puvion-Dutilleul, M.C. Guillemin, A. Viron, G. Linares-Cruz, N. Stuurman, L. de Jong, C. Szostecki, F. Calvo, and C. Chomienne The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion EMBO J. 13 1994 1073 1083
23. E. Duprez, A.J. Saurin, J.M. Desterro, V. Lallemand-Breitenbach, K. Howe, M.N. Boddy, E. Solomon, H. de The, R.T. Hay, and P.S. Freemont SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation J. Cell Sci. 112 Pt. 3 1999 381 393
24. R.J. Lin, and R.M. Evans Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers Mol. Cell 5 2000 821 830
25. S. Minucci, M. Maccarana, M. Cioce, P. De Luca, V. Gelmetti, S. Segalla, L. Di Croce, S. Giavara, C. Matteucci, A. Gobbi, A. Bianchini, E. Colombo, I. Schiavoni, G. Badaracco, X. Hu, M.A. Lazar, N. Landsberger, C. Nervi, and P.G. Pelicci Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation Mol. Cell 5 2000 811 820
26. M.M. Khan, T. Nomura, H. Kim, S.C. Kaul, R. Wadhwa, T. Shinagawa, E. Ichikawa-Iwata, S. Zhong, P.P. Pandolfi, and S. Ishii Role of PML and PML-RARalpha in Mad-mediated transcriptional repression Mol. Cell 7 2001 1233 1243
27. M.M. Khan, T. Nomura, H. Kim, S.C. Kaul, R. Wadhwa, S. Zhong, P.P. Pandolfi, and S. Ishii PML-RARalpha alleviates the transcriptional repression mediated by tumor suppressor Rb J. Biol. Chem. 276 2001 43491 43494
28. E. Duprez, K. Wagner, H. Koch, and D.G. Tenen C/EBPbeta: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells EMBO J 22 2003 5806 5816
29. M.C. Pizzorno, and G.S. Hayward The IE2 gene products of human cytomegalovirus specifically down-regulate expression from the major immediate-early promoter through a target sequence located near the cap site J. Virol. 64 1990 6154 6165
30. H.R. Lee, D.J. Kim, J.M. Lee, C.Y. Choi, B.Y. Ahn, G.S. Hayward, and J.H. Ahn Ability of the human cytomegalovirus IE1 protein to modulate sumoylation of PML correlates with its functional activities in transcriptional regulation and infectivity in cultured fibroblast cells J. Virol. 78 2004 6527 6542
31. S. Green, P. Isseman, and E. Sheer A versatile in vivo and in vitro eukaryotic expression vector for protein engineering Nucleic Acids Res. 16 1988 369
32. J.H. Ahn, Y. Xu, W.J. Jang, M.J. Matunis, and G.S. Hayward Evaluation of interactions of human cytomegalovirus immediate-early IE2 regulatory protein with small ubiquitin-like modifiers and their conjugation enzyme Ubc9 J. Virol. 75 2001 3859 3872
33. J.H. Ahn, E.J. Brignole III, and G.S. Hayward Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML Mol. Cell. Biol. 18 1998 4899 4913
34. I. Riviere, K. Brose, and R.C. Mulligan Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells Proc. Natl. Acad. Sci. USA 92 1995 6733 6737
35. J.H. Ahn, and G.S. Hayward Disruption of PML-associated nuclear bodies by IE1 correlates with efficient early stages of viral gene expression and DNA replication in human cytomegalovirus infection Virology 274 2000 39 55
36. T. Kamitani, K. Kito, H.P. Nguyen, H. Wada, T. Fukuda-Kamitani, and E.T. Yeh Identification of three major sentrinization sites in PML J. Biol. Chem. 273 1998 26675 26682
37. S. Muller, and A. Dejean Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption J.Virol. 73 1999 5137 5143
38. S. Vallian, J.A. Gaken, I.D. Trayner, E.B. Gingold, T. Kouzarides, K.S. Chang, and F. Farzaneh Transcriptional repression by the promyelocytic leukemia protein, PML Exp. Cell Res. 237 1997 371 382
39. A. Kentsis, R.E. Gordon, and K.L. Borden Control of biochemical reactions through supramolecular RING domain self-assembly Proc. Natl. Acad. Sci. USA 99 2002 15404 15409
40. S. Muller, A. Ledl, and D. Schmidt SUMO: a regulator of gene expression and genome integrity Oncogene 23 2004 1998 2008
41. E.S. Johnson Protein modification by SUMO Annu. Rev. Biochem. 73 2004 355 382
42. S.H. Yang, and A.D. Sharrocks SUMO promotes HDAC-mediated transcriptional repression Mol. Cell 13 2004 611 617
43. H. Li, C. Leo, J. Zhu, X. Wu, J. O'Neil, E.J. Park, and J.D. Chen Sequestration and inhibition of Daxx-mediated transcriptional repression by PML Mol. Cell. Biol. 20 2000 1784 1796