Cytisine derivatives as high affinity nAChR ligands: Synthesis and comparative molecular field analysis

Farmaco

Volumn 57, Issue 6, 2002, Pages 469-478

  Nicolotti, O ^a   Canu Boido, C ^b   Sparatore, F ^b   Carotti, A ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

3D QSAR; N substituted cytisines; Neuronal nicotine acetylcholine receptors; Scrambling

Indexed keywords

1 (CYTISIN 12 YL) 4 (PYRROLIDIN 1 YL) 2 BUTYNE; 1,4 BIS(CYTISIN 12 YL) 2 BUTYNE; 3,5 NITROCYTISINE; CHOLINERGIC RECEPTOR STIMULATING AGENT; CYTISINE DERIVATIVE; N (4 CHLORO 2 BUTYN 1 YL)CYTISINE; N (CYCLOHEXYLAMINOTHIOCARBONYL)CYTISINE; N (ETHOXYCARBONYL)CYTISINE; N ALLYLCYTISINE; N ISOPROPYLCYTISINE; N NITROSO 3,5 NITROCYTISINE; N PRENYLCYTISINE; N PROPARGYLCYTISINE; UNCLASSIFIED DRUG; ALKALOID; AZOCINE DERIVATIVE; CYTISINE; LIGAND; NICOTINIC RECEPTOR; QUINOLIZINE DERIVATIVE;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MOLECULAR MODEL; NONHUMAN; PREDICTION; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; ANIMAL; BRAIN CORTEX; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; KINETICS; METABOLISM; METHODOLOGY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RADIOASSAY; STATISTICS; SYNTHESIS; WISTAR RAT;

ALKALOIDS; ANIMAL; CEREBRAL CORTEX; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; STATISTICS; SUPPORT, NON-U.S. GOV'T; ANIMALS; AZOCINES; QUINOLIZINES;

EID: 0036598354     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(02)01216-8     Document Type: Article

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