Differential effects of RhoA signaling on anticancer agent-induced cell death

Oncology Reports

Volumn 13, Issue 2, 2005, Pages 299-304

  Kang, Won Ki ^a   Lee, Inkyoung ^a   Ko, Ukyoung ^b   Park, Chaehwa ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Samsung Medical Center   (South Korea)

Author keywords

5 FU; Cell death; Etoposide; PC 3; Resistance; RhoA

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; ETOPOSIDE; FLUOROURACIL; MEVINOLIN; PACLITAXEL; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA PROTEIN, HUMAN; VINCRISTINE;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE; CELL DEATH; DRUG EFFECT; DRUG RESISTANCE; GENETIC TRANSFECTION; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL CYCLE; CELL DEATH; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; FLUOROURACIL; HUMANS; LOVASTATIN; PACLITAXEL; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED; VINCRISTINE;

EID: 16244410502     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Bourne HR, Sanders DA and McCormick F: The GTPase superfamily: conserved structure and molecular mechanism. Nature 349: 117-127, 1991. (Pubitemid 21912023)
2. Khosravi-Far R, Solski PA, Clark GJ, Kinch MS and Der CJ: Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol Cell Biol 15: 6443-6453, 1995.
3. Moorman JP, Bobak DA and Hahn CS: Inactivation of the small GTP binding protein Rho induces multinucleate cell formation and apoptosis in murine T lymphoma EL4. J Immunol 156: 4146-4153, 1996. (Pubitemid 26165809)
4. Perona R, Esteve P, Jimenez B, et al: Tumorigenic activity of rho genes from Aplysia californica. Oncogene 8: 1285-1292, 1993. (Pubitemid 23129852)
5. Prendergast GC, Khosravi-Far R, Solski PA, Kurzawa H, Lebowitz PF and Der CJ: Critical role of Rho in cell transformation by oncogenic Ras. Oncogene 10: 2289-2296, 1995.
6. Yoshioka K, Nakamori S and Itoh K: Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells. Cancer Res 59: 2004-2010, 1999. (Pubitemid 29186178)
7. Moscow JA, He R, Gnarra JR, et al: Examination of human tumors for rhoA mutations. Oncogene 9: 189-194, 1994. (Pubitemid 24020949)
8. Bobak D, Moorman J, Guanzon A, Gilmer L and Hahn C: Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis. Oncogene 15: 2179-2189, 1997. (Pubitemid 27493907)
9. Esteve P, del Peso L and Lacal JC: Induction of apoptosis by rho in NIH 3T3 cells requires two complementary signals. Ceramides function as a progression factor for apoptosis. Oncogene 11: 2657-2665, 1995. (Pubitemid 26023834)
10. Fiorentini C, Fabbri A, Matarrese P, Falzano L, Boquet P and Malorni W: Hinderance of apoptosis and phagocytic behaviour induced by Escherichia coli cytotoxic necrotizing factor 1: two related activities in epithelial cells. Biochem Biophys Res Commun 241: 341-346, 1997. (Pubitemid 28020103)
11. Jimenez B, Arends M, Esteve P, et al: Induction of apoptosis in NIH3T3 cells after serum deprivation by overexpression of rho-p21, a GTPase protein of the ras superfamily. Oncogene 10: 811-816, 1995.
12. Dorkin TJ and Neal DE: Basic science aspects of prostate cancer Semin Cancer Biol 8: 21-27, 1997. (Pubitemid 27417426)
13. Tang DG and Porter AT: Target to apoptosis: a hopeful weapon for prostate cancer. Prostate 32: 284-293, 1997. (Pubitemid 27374201)
14. Carson JP, Kulik G and Weber MJ: Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3′-kinase and Akt/protein kinase B. Cancer Res 59: 1449-1453, 1999. (Pubitemid 29160109)
15. Lin J, Adam RM, Santiestevan E and Freeman MR: The phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. Cancer Res 59: 2891-2897, 1999. (Pubitemid 29283128)
16. Katoh H, Aoki J, Ichikawa A and Negishi M: p160 RhoA-binding kinase ROKalpha induces neurite retraction. J Biol Chem 273: 2489-2492, 1998. (Pubitemid 28133885)
17. Park C, Lee I and Kang WK: Lovastatin-induced E2F-1 modulation and its effect on prostate cancer cell death. Carcinogenesis 22: 1727-1731, 2001. (Pubitemid 32952154)
18. Kroemer G and Reed JC: Mitochondrial control of cell death. Nat Med 6: 513-519, 2000. (Pubitemid 30305900)
19. Nicholson DW: From bench to clinic with apoptosis-based therapeutic agents. Nature 407: 810-816, 2000.
20. Goldstein JL and Brown MS: Regulation of the mevalonate pathway. Nature 343: 425-430, 1990.
21. Wang CY, Mayo MW, Korneluk RG, Goeddel DV and Baldwin AS Jr: NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and C-IAP2 to suppress caspase-8 activation. Science 281: 1680-1683, 1998.
22. Aota K, Azuma M, Yamashita T, et al: 5-Fluorouracil induces apoptosis through the suppression of NF-kappaB activity in human salivary gland cancer cells. Biochem Biophys Res Commun 273: 1168-1174, 2000. (Pubitemid 30481097)
23. Chandra D, Choy G, Deng X, Bhatia B, Daniel P and Tang DG: Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death. Mol Cell Biol 24: 6592-6607, 2004. (Pubitemid 38944340)
24. Das KC and White CW: Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C. J Biol Chem 272: 14914-14920, 1997. (Pubitemid 27251763)
25. Cory JG, Breland JC and Carter GL: Effect of 5-fluorouracil on RNA metabolism in Novikoff hepatoma cells. Cancer Res 39: 4905-4913, 1979. (Pubitemid 10167718)
26. Spears CP, Gustavsson BG, Mitchell MS, et al: Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil. Cancer Res 44: 4144-4150, 1984. (Pubitemid 14041649)