The effect of conformation on membrane permeability of an acyloxyalkoxy-linked cyclic prodrug of a model hexapeptide

Pharmaceutical Research

Volumn 13, Issue 11, 1996, Pages 1657-1662

  Gangwar, Sanjeev ^a   Jois, Seetharama D S ^a   Siahaan, Teruna J ^a   Vander Velde, David G ^a   Stella, Valentino J ^a   Borchardt, Ronald T ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Circular dichroism; Esterase sensitive prodrug; Membrane permeability; Nuclear magnetic resonance spectroscopy; Peptide delivery; Solution conformation

Indexed keywords

HEXAPEPTIDE; PRODRUG;

ARTICLE; CIRCULAR DICHROISM; CONFORMATION; LIPOPHILICITY; MEMBRANE PERMEABILITY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

CELL MEMBRANE PERMEABILITY; CHEMISTRY, PHYSICAL; CIRCULAR DICHROISM; MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES, CYCLIC; PRODRUGS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030480443     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016484522113     Document Type: Article

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