In utero exposure to environmental estrogens and male reproductive health: A systematic review of biological and epidemiologic evidence

Reproductive Toxicology

Volumn 20, Issue 1, 2005, Pages 5-20

  Vidaeff, Alex C ^a   Sever, Lowell E ^b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Cryptorchidism; Environmental estrogens; Hypospadias; Prenatal exposure; Xenoestragen

Indexed keywords

CHLORPHENOTANE; ENDOCRINE DISRUPTOR; ESTROGEN; METHOXYCHLOR; ORGANOCHLORINE DERIVATIVE; PESTICIDE; PHENOL DERIVATIVE; PHYTOESTROGEN; POLYCHLORINATED BIPHENYL DERIVATIVE;

BIOLOGY; CRYPTORCHISM; DATA ANALYSIS; DEVELOPMENTAL DISORDER; DISEASE ASSOCIATION; ENDOCRINE DISEASE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; EPIDEMIOLOGICAL DATA; ESTROGEN ACTIVITY; HEALTH HAZARD; HORMONE ACTION; HUMAN; HYPOSPADIAS; HYPOTHESIS; MALE; MALE GENITAL SYSTEM; MALE GENITAL SYSTEM DISEASE; MALE INFERTILITY; MEASUREMENT; MEDICAL DOCUMENTATION; MEDICAL RESEARCH; METABOLISM; METHODOLOGY; NONHUMAN; OUTCOMES RESEARCH; POPULATION RESEARCH; PREGNANCY; PRENATAL EXPOSURE; REPRODUCTIVE HEALTH; REVIEW; SCIENCE; SEMEN ANALYSIS; SPERMATOZOON ABNORMALITY; SPERMATOZOON MOTILITY; STATISTICAL ANALYSIS; SYSTEMATIC REVIEW; UTERUS;

EID: 16244368490     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2004.12.015     Document Type: Review

References (113)

1. L.J. Paulozzi, J.D. Erickson, and R.J. Jackson Hypospadias trends in two American surveillance systems Pediatrics 100 1997 831 834
2. C. Sultan, P. Balaguer, and B. Terouanne Environmental xenoestrogens, antiandrogens and disorders of male sexual differentiation Mol Cel Endocrinol 178 2001 99 105
3. E. Carlsen, A. Giwercman, N. Keiding, and N.E. Skakkebaek Evidence for decreasing quality of semen during the past 50 years Br Med J 305 1992 609 613
4. E. Carlsen, A. Giwercman, N. Keiding, and N.E. Skakkebaek Declining semen quality and increasing incidence of testicular cancer: is there a common cause? Environ Health Perspect 103 suppl. 7 1995 137 139
5. J.A. McLachlan Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals Endocr Rev 22 2001 319 341
6. T. Colborn C. Clement Wingspread consensus statement. Chemically Induced Alterations in Sexual, Functional Development: The Wildlife/Human Connection 1992 Princeton Scientific Publishing Princeton 1 8
7. European Workshops on Endocrine Disrupters; 2001, June 18-20, Aronsborg, Sweden. European Commission, 2001.
8. R.S. Swerdloff Infertility in the male Ann Int Med 103 1985 906 919
9. Male reproductive health and environmental oestrogens. Lancet 1995;345:933-5 (Editorial).
10. D.J. Handelsman Estrogens and falling sperm counts Reprod Fertil Dev 13 2001 317 324
11. S.H. Swan, E.P. Elkin, and L. Fenster The question of declining sperm density revisited: an analysis of 101 studies published Environ Health Perspect 108 2000 961 966
12. A.S. Morrison Cryptorchidism, hernia and cancer of the testis J Natl Cancer Inst 56 1976 731 733
13. P. Canlorbe, J.E. Toublanc, and M. Roger Etude de la fonction endocrine dans 125 cas de cryptorchidies Ann Med Interne (Paris) 125 1974 365 369
14. M.B. Toledano, A.L. Hansell, L. Jarup, M. Quinn, S. Jick, and P. Elliot Temporal trends in orchidopexy, Great Britain, 1992-1998 Environ Health Perspect 111 2003 129 132
15. L.J. Paulozzi International trends in rates of hypospadias and cryptorchidism Environ Health Perspect 107 1999 297 302
16. P. Matlai, and V. Beral Trends in congenital malformations of external genitalia Lancet I 1985 108
17. W.A. Kennedy II, and H.M. Snyder III Paediatric andrology: the impact of environmental pollutants BJU Int 83 1999 195 200
18. N.E. Skakkebaek, E. Rajpert-De Meyts, and K.M. Main Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects Hum Reprod 16 2001 972 978
19. A.G. Andersen, T.K. Jensen, and E. Carlsen High frequency of sub-optimal semen quality in an unselected population of young men Hum Reprod 15 2000 366 372
20. N. Olea, F. Olea-Serrano, P. Lardelli-Claret, A. Rivas, and A. Barba-Navarro Inadvertent exposure to xenoestrogens in children Toxicol Ind Health 15 1999 151 158
21. S. Koifman, R.J. Koifman, and A. Meyer Human reproductive system disturbances and pesticide exposure in Brazil Cad Saude Publica 18 2002 435 445
22. C.F. Facemire, T.S. Gross, and LJ. Guilette Jr. Reproductive impairment in the Florida panther: nature or nurture? Environ Health Perspect 103 suppl. 4 1995 79 86
23. L.J. Guillette Jr., T.S. Gross, and G.R. Masson Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida Environ Health Perspect 102 1994 680 688
24. P. Matthiessen, and J.P. Sumpter Effects of estrogenic substances in the aquatic environment EXS 86 1998 319 335
25. P.L. Singer Occupational oligospermia JAMA 140 1949 1249
26. P.S. Guzelian Comparative toxicology of chlorodecone (Kepone) in humans and experimental animals Ann Rev Pharm Tox 22 1982 89 113
27. M.M. Quinn, D.H. Wegman, and I.A. Greaves Investigation of reports of sexual dysfunction among male chemical workers manufacturing stilbene derivatives Am J Ind Med 18 1990 55 68
28. A.M. Soto, H. Justicia, J.W. Wray, and C. Sonnenschein p-Nonyl-phenol - an estrogenic xenobiotic released from "modified" polystyrene Environ Health Perspect 92 1991 167 173
29. K. Cahow The cancer conondrum Environ Health Perspect 103 1995 998 1004
30. W.R. Kelce, C.R. Stone, S.C. Laws, L.E. Gray Jr., J.A. Kemppainen, and E.M. Wilson Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist Nature 375 1995 581 585
31. S.Y. Amstislavsky, T.G. Amstislavskaya, and V.P. Eroschenko Methoxychlor given in the periimplantation period blocks sexual arousal in male mice Reprod Toxicol 13 1999 405 411
32. A.M. Cummings Methoxychlor as a model for environmental estrogens Crit Rev Toxicol 27 1997 367 379
33. C. Sonnenschein, and A.M. Soto An updated review of environmental estrogen and androgen mimics and antagonists J Steroid Biochem Mol Biol 65 1998 143 150
34. T.E. Schafer, C.A. Lapp, C.M. Hanes, and J.B. Lewis What parents should know about estrogen-like compounds in dental materials Pediatr Dent 22 2000 75 76
35. J.B. Knaak, J.M. Elridge, and L.J. Sullivan Excretion of certain polyethylene glycol ether adducts of nonylphenol by the rat Toxicol Appl Pharmacol 9 1966 331 340
36. A. Stoica, B.S. Katzenellenbogen, and M.B. Martin Activation of estrogen receptor-α by the heavy metal cadmium Mol Endocrinol 14 2000 545 553
37. S. Safe, K. Connor, and K. Gaido Methods for xenoestrogen testing Toxicol Lett 102/103 1998 665 670
38. D. Ganmaa, P.Y. Wang, L.Q. Qin, K. Hoshi, and A. Sato Is milk responsible for male reproductive disorders? Med Hypotheses 57 2001 510 514
39. G.H. Degen, and H.M. Bolt Endocrine disruptors: update on xenoestrogens Int Arch Occup Environ Health 73 2000 433 441
40. L.K. Irwin, S. Gray, and E. Oberdoster Vitellogenin induction in painted turtle, Chrysemys picta, as a biomarker of exposure to environmental levels of estradiol Aquat Toxicol 55 2001 49 60
41. E.C. Dodds, L. Goldberg, W. Lawson, and R. Robinson Oestrogenic activity of certain synthetic compounds Nature 141 1938 247 249
42. W.B. Gill, Schumacher GFB, and M. Bibbo Pathological semen and anatomical abnormalities of the genital tract in human male subjects exposed to diethylstilbestrol in utero J Urol 117 1977 477 480
43. K. Roine, E.L. Korpinen, and K. Kallela Mycotoxicosis as a probable cause of infertility in dairy cows Nord Vet Med 23 1971 628 633
44. M.S. Kurzer, and X. Xu Dietary phytoestrogens Annu Rev Nutr 17 1997 353 381
45. R. Santti, S. Makela, L. Strauss, J. Korkman, and M.L. Kostian Phytoestrogens: potential endocrine disruptors in males Toxicol Ind Health 14 1998 223 237
46. K.S. Korach Insights from the study of animals lacking functional estrogen receptor Science 266 1994 1524 1527
47. E.P. Smith, J. Boyd, and G.R. Frank Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man N Engl J Med 331 1994 1056 1061
48. A. Bartke, Williams KIH, and S. Dalterio Effects of estrogens on testicular testosterone production in vitro Biol Reprod 17 1977 645 649
49. R.M. Sharpe, and N.E. Skakkebaek Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet I 1993 1392 1395
50. R.A. Hess, D. Bunick, and K-H. Lee A role for oestrogens in the male reproductive system Nature 390 1997 509 512
51. L. Johnson, S.W. Brown, and J.J. Barnard Decline in Leydig cell volume in a group of North American men over the last 16 years J Androl 18 suppl. 1997 P33
52. I.M. Adham, E. Burkhardt, M. Benahmed, and W. Engel Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells J Biol Chem 268 1993 26668 26672
53. S. Nef, T. Shipman, and L.F. Parada A molecular basis for estrogen-induced cryptorchidism Dev Biol 224 2000 354 361
54. R.R. Newbold, Y. Suzuki, and J.A. McLachlan Müllerian duct maintenance in heterotypic organ culture after in vivo exposure to diethylstilbestrol Endocrinology 115 1984 1863 1868
55. S.H. Safe Is there an association between exposure to environmental estrogens and breast cancer? Environ Health Perspect 105 suppl. 3 1997 675 678
56. E.J. Routledge, R. White, M.G. Parker, and J.P. Sumpter Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor ER-α and ER-β J Biol Chem 275 2000 35986 35993
57. G.J.M. Kuiper, J.G. Lemmen, and B. Carlsson Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β Endocrinol 139 1998 4252 4263
58. B. Gutendorf, and J. Westendorf Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens Toxicology 166 2001 79 89
59. A.R. Cunningham, G. Klopman, and H.S. Rosenkranz A dichotomy in the lipophilicity of natural estrogens, xenoestrogens, and phytoestrogens Environ Health Perspect 105 suppl. 3 1997 665 668
60. A.K. Loomis, and P. Thomas Effects of estrogens and xenoestrogens on androgen production by Atlantic croaker testes in vitro: evidence for a nongenomic action mediated by an estrogen membrane receptor Biol Reprod 62 2000 995 1004
61. S. Das, and P. Thomas Pesticides interfere with the nongenomic action of a progestogen on meiotic maturation by binding to its plasma membrane receptor on fish oocytes Endocrinol 140 1999 1953 1956
62. A. Nadal, A.B. Ropero, O. Laribi, M. Maillet, E. Fuentes, and B. Soria Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor α and estrogen receptor β Proc Natl Acad Sci USA 97 2000 11603 11608
63. F. Gozzo, and J.H. Poupaert Xenoestrogens, pollution and health: a critical review J Pharm Belg 53 1998 278 286
64. L.E. Gray Jr., and J. Ostby Effects of pesticides and toxic substances on behavioral and morphological reproductive development: endocrine versus nonendocrine mechanisms Toxicol Ind Health 14 1998 159 184
65. M. Luconi, M. Muratori, G. Forti, and E. Baldi Identification and characterization of a novel functional estrogen receptor on human sperm membrane that interferes with progesterone effects J Clin Endocrinol Metab 84 1999 1670 1678
66. M. Luconi, L. Bonaccorsi, G. Forti, and E. Baldi Effects of estrogenic compounds on human spermatozoa: evidence for interaction with a nongenomic receptor for estrogen on human sperm membrane Mol Cell Endocrinol 178 2001 39 45
67. J. Toppari, J.C. Larsen, and P. Christiansen Male reproductive health and environmental xenoestrogens Environ Health Perspect 104 suppl. 4 1996 741 803
68. R. Bigsby, R. Chapin, and G. Daston Evaluating the effects of endocrine disruptors on endocrine function during development Environ Health Perspect 107 suppl. 4 1999 613 618
69. P.T. Saunders, G. Majdic, and P. Parte Fetal and perinatal influence of xenoestrogens on testis gene expression Adv Exp Med Biol 424 1997 99 110
70. F. vom Saal, B. Timms, and M. Montano Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses Proc Natl Acad Sci U S A 94 1997 2056 2061
71. R.J. Golden, K.L. Noller, and L. Titus-Ernstoff Environmental endocrine modulators and human health: an assessment of the biological evidence Crit Rev Toxicol 28 1998 109 227
72. J. Sun, M.J. Meyers, B.E. Fink, R. Rajendran, J.A. Katzenellenbogen, and B.S. Katzenellenbogen Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-α or estrogen receptor-β Endocrinology 140 1999 800 804
73. C.M. Markey, C.L. Michaelson, E.C. Veson, C. Sonnenschein, and A.M. Soto The mouse uterotropic assay: a re-evaluation of its validity in assessing the estrogenicity of bisphenol A Environ Health Perspect 109 2001 55 60
74. D.M. Sheehan Activity of environmentally relevant low doses of endocrine disruptors and the bisphenol A controversy: initial results confirmed Proc Soc Exp Biol Med 224 2000 57 60
75. C. Gupta Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals Proc Soc Exp Biol Med 224 2000 61 68
76. J. Kaiser Panel cautiously confirms low-dose effects Science 290 2000 695 697
77. L.E. Gray, J. Ostby, E. Monosson, and W.R. Klece Environmental antiandrogens: low doses of the fungicide vinclozolin alter sexual differentiation of the male rat Toxicol Ind Health 15 1999 48 64
78. NIEHS, National Toxicology Program (NTP) (2001) Endocrine Disruptors Low Dose Peer Review Report, August 2001, pp. 1-467.
79. H.L. Bradlow, D.L. Davis, G. Lin, D. Sepovic, and R. Tiwari Effects of pesticides on the ratio of 16α/2-hydroxyoestrone: a biological marker of breast cancer risk Environ Health Perspect 103 suppl. 7 1995 147 150
80. D.M. Sheehan, and M. Young Diethylstilbestrol and estradiol binding to serum albumin and pregnancy plasma of rat and human Endocrinology 104 1979 1442 1446
81. S.C. Nagel, F.S. vom Saal, and W.V. Welshons The effective free fraction of estradiol and xenoestrogens in human serum measured by whole cell uptake assays: physiology of delivery modifies estrogenic activity Proc Soc Exp Biol Med 217 1998 300 309
82. J. Payne, N. Rajapakse, M. Wilkins, and A. Kortenkamp Prediction and assessment of the effects of mixtures of four xenoestrogens Environ Health Perspect 108 2000 983 987
83. A. Soto, M.F. Fernandez, M.F. Luizzi, A.S. Oles Karasko, and C. Sonnenschein Developing a marker of exposure to xenoestrogen mixtures in human serum Environ Health Perspect 105 1997 647 654
84. LE. Gray Jr. Xenoendocrine disrupters: laboratory studies on male reproductive effects Toxicol Lett 102-103 1998 331 335
85. D.Q. Tran, D.M. Klotz, B.L. Ladlie, C.F. Ide, J.A. McLachlan, and S.F. Arnold Inhibition of progesterone receptor activity in yeast by synthetic chemicals Biochem Biophys Res Commun 229 1996 518 523
86. P. Sohoni, and J.P. Sumpter Several environmental oestrogens are also anti-androgens J Endocrinol 158 1998 327 339
87. V.F. Garry, D. Schreinemachers, M.E. Harkins, and J. Griffith Pesticide appliers, biocides, and birth defects in rural Minnesota Environ Health Perspect 104 1996 394 399
88. R. Rozati, P.P. Reddy, P. Reddanna, and R. Mujtaba Xenoestrogens and male infertility: myth or reality? Asian J Androl 2 2000 263 269
89. A. Oliva, A. Spira, and L. Multigner Contribution of environmental factors to the risk of male infertility Hum Reprod 16 2001 1768 1776
90. J.W. Dallinga, E.J.C. Moonen, J.C.M. Dumoulin, J.L.H. Evers, J.P.M. Geraedts, and J.C.S. Kleinjans Decreased human semen quality and organochlorine compounds in blood Hum Reprod 17 2002 1973 1979
91. M. Restrepo, N. Munoz, and N. Day Birth defects among children born to a population occupationally exposed to pesticides in Colombia Scand J Work Environ Health 16 1990 239 246
92. J. Garcia-Rodriguez, M. Garcia-Martin, and M. Nogueras-Ocana Exposure to pesticides and cryptorchidism: geographical evidence of a possible association Environ Health Perspect 104 1996 1090 1095
93. P. Kristensen, L.M. Irgens, A. Andersen, A.S. Bye, and L. Sundheim Birth defects among offspring of Norwegian farmers Epidemiology 8 1997 537 544
94. I.S. Weidner, H. Moller, T.K. Jensen, and N.E. Skakkebaek Cryptorchidism and hypospadias in sons of gardeners and farmers Environ Health Perspect 106 1998 793 796
95. M.P. Longnecker, M.A. Klebanoff, and J.W. Brock Maternal serum level of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene and risk of cryptorchidism, hypospadias, and polythelia among male offspring Am J Epidemiol 155 2002 313 322
96. J.H. Mitchell, E. Cawood, D. Kinniburgh, A. Provan, A.R. Collins, and D.S. Irvine Effect of a phytoestrogen food supplement on reproductive health in normal males Clin Sci 100 2001 613 618
97. A. Schecter, J.J. Ryan, and Y. Masuda Chlorinated and brominated dioxins and dibenzofurans in human tissue following exposure Environ Health Perspect 102 suppl. 1 1994 135 147
98. E. Dewailly, J.J. Ryan, and C. Laliberte Exposure of remote maritime populations to coplanar PCBs Environ Health Perspect 102 suppl. 1 1994 205 209
99. S.C. Ensslen, H.H. Riedel, H. Bluthgen, and W. Heeschen Chlorinated hydrocarbons in seminal plasma and male fertility Zentralbl Gynakol 112 1990 817 821
100. F.W. Kutz, P.H. Wood, and D.P. Bottimore Organochlorine pesticides and polychlorinated biphenyls in human adipose tissue Rev Environ Contam Toxicol 120 1991 1 82
101. K.D. Setchell, S.J. Gosselin, and M.B. Welsh Dietary estrogens-a probable cause of infertility and liver disease in captive cheetahs Gastroenterology 93 1987 225 233
102. C.H.T. Adlercreutz, B.G. Goldin, and S.L. Gorbach Soybean phytoestrogen intake and cancer risk J Nutr 125 1995 757S 770S
103. D.F. Stroup, J.A. Berlin, and S.C. Morton Meta-analysis of observational studies in epidemiology JAMA 283 2000 2008 2012
104. R.M. Sharpe Environment, lifestyle and male infertility Baillieres Best Pract Res Clin Endocrinol Metab 14 2000 489 503
105. S.H. Swan, E.P. Elkin, and L. Fenster Have sperm densities declined? A reanalysis of global trend data Environ Health Perspect 105 1997 1228 1232
106. N. Itoh, F. Kayama, J. Tatsuki, and T. Tsukamoto Have sperm counts deteriorated over the past 20 years in healthy, young Japanese men? Results from the Sapporo area J Androl 22 2001 40 44
107. J. Auger, J.M. Kunstmann, F. Czyglik, and P. Jouannet Decline in semen quality among fertile men in Paris during the past 20 years N Engl J Med 332 1995 281 285
108. L. Bujan, A. Mansat, F. Pontonnier, and R. Mieusset Time series analysis of sperm concentration in fertile men in Toulouse, France between 1977 and 1992 Br J Med 312 1996 471 472
109. F.X. Gassner, E.C. Reifenstein Jr., J.W. Algeo, and W.E. Mattox Effects of hormones on growth, fattening, and meat production potential of livestock Recent Prog Horm Res 14 1958 183 217
110. M. Joffe Are problems with male reproductive health caused by endocrine disruption? Occup Environ Med 58 2001 281 296
111. S. Krimsky Hormonal Chaos: The Scientific and Social Origins of the Environmental Endocrine Hypothesis 2000 Johns Hopkins University Press Baltimore, MD
112. A.M. Soto, and C. Sonnenschein Endocrine disruptors: a very personal story with multiple personalities Gac Sanit 16 2002 209 211
113. US EPA. Special report on environmental endocrine disruption: an effects assessment and analysis. US Environmental Protection Agency, EPA/630/R-012,Washington, DC, February 1997.