Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of Vater

Journal of Clinical Oncology

Volumn 23, Issue 9, 2005, Pages 1811-1818

  Hansel, Donna E ^a   Maitra, Anirban ^a   Lin, John W ^a   Goggins, Michael ^a   Argani, Pedram ^a   Yeo, Charles J ^a   Piantadosi, Steven ^a   Leach, Steven D ^a   Biankin, Andrew V ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR CDX1; TRANSCRIPTION FACTOR CDX2; HOMEODOMAIN PROTEIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; CANCER INVASION; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT; PANCREAS ADENOCARCINOMA; PANCREAS DUCT; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SINGLE BLIND PROCEDURE; UNIVARIATE ANALYSIS; VATER PAPILLA CARCINOMA; ADENOCARCINOMA; BILE DUCT TUMOR; BILIARY TRACT TUMOR; METABOLISM; MIDDLE AGED; MORTALITY; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY; SURVIVAL RATE; VATER PAPILLA;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; AMPULLA OF VATER; BILIARY TRACT NEOPLASMS; COMMON BILE DUCT NEOPLASMS; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; PROGNOSIS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 15744399332     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2005.03.068     Document Type: Article

References (32)

1. Yeo CJ, Sohn TA, Cameron JL, et al: Periampullary adenocarcinoma: Analysis of 5-year survivors. Ann Surg 227:821-831, 1998
2. Naef M, Buhlmann M, Metzger D, et al: Periampullary carcinomas: A special entity of duodenal tumors. Swiss Surg 5:11-13, 1999
3. Sellner FJ, Riegler FM, Machacek E: Implications of histological grade of tumour for the prognosis of radically resected periampullary adenocarcinoma. Eur J Surg 165:865-870, 1999
4. Bouvet M, Gamagami RA, Gilpin EA, et al: Factors influencing survival after resection for periampullary neoplasms. Am J Surg 180:13-17, 2000
5. van Geenen RC, van Gulik TM, Offerhaus GJ, et al: Survival after pancreaticoduodenectomy for periampullary adenocarcinoma: An update. Eur J Surg Oncol 27:549-557, 2001
6. Willett CG, Warshaw AL, Convery K, et al: Patterns of failure after pancreaticoduodenectomy for ampullary carcinoma. Surg Gynecol Obstet 176:33-38, 1993
7. Matory YL, Gaynor J, Brennan M: Carcinoma of the ampulla of Vater. Surg Gynecol Obstet 177:366-370, 1993
8. Talamini MA, Moesinger RC, Pitt HA, et al: Adenocarcinoma of the ampulla of Vater: A 28-year experience. Ann Surg 225:590-599, 1997
9. Subramanian V, Meyer BI, Gruss P: Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell 83:641-653, 1995
10. Tamai Y, Nakajima R, Ishikawa T, et al: Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice. Cancer Res 59:2965-2970, 1999
11. Beck F, Tata F, Chawengsaksophak K: Homeobox genes and gut development. Bioessays 22:431-441, 2000
12. Bonner CA, Loftus SK, Wasmuth JJ: Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene. Genomics 28:206-211, 1995
13. Mallo GV, Rechreche H, Frigerio JM, et al: Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox: Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int J Cancer 74:35-44, 1997
14. Silberg DG, Swain GP, Suh ER, et al: Cdx1 and cdx2 expression during intestinal development. Gastroenterology 119:961-971, 2000
15. James R, Erler T, Kazenwadel J: Structure of the murine homeobox gene cdx-2: Expression in embryonic and adult intestinal epithelium. J Biol Chem 269:15229-15237, 1994
16. Beck F, Chawengsaksophak K, Luckett J, et al: A study of regional gut endoderm potency by analysis of Cdx2 null mutant chimaeric mice. Dev Biol 255:399-406, 2003
17. Ee HC, Erler T, Bhathal PS, et al: Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma. Am J Pathol 147:586-592, 1995
18. Vider BZ, Zimber A, Chastre E, et al: Deregulated expression of homeobox-containing genes, HOXB6, B8, C8, C9, and Cdx-1, in human colon cancer cell lines. Biochem Biophys Res Commun 272:513-518, 2000
19. Silberg DG, Furth EE, Taylor JK, et al: CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium. Gastroenterology 113:478-486, 1997
20. Mallo GV, Soubeyran P, Lissitzky JC, et al: Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. J Biol Chem 273:14030-14036, 1998
21. Mizoshita T, Tsukamoto T, Nakanishi H, et al: Expression of Cdx2 and the phenotype of advanced gastric cancers: Relationship with prognosis. J Cancer Res Clin Oncol 129:727-734, 2003
22. Suh E, Traber PG: An intestine-specific homeobox gene regulates proliferation and differentiation. Mol Cell Biol 16:619-625, 1996
23. Almeida R, Silva E, Santos-Silva F, et al: Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. J Pathol 199:36-40, 2003
24. Werling RW, Yaziji H, Bacchi CE, et al: CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: An immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol 27:303-310, 2003
25. Silberg DG, Sullivan J, Kang E, et al: Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology 122:689-696, 2002
26. Jin T, Drucker DJ: Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3. Mol Cell Biol 16:19-28, 1996
27. Laser B, Meda P, Constant I, et al: The caudal-related homeodomain protein Cdx-2/3 regulates glucagon gene expression in islet cells. J Biol Chem 271:28984-28994, 1996
28. van Heek NT, Meeker AK, Kern SE, et al: Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am J Pathol 161:1541-1547, 2002
29. Mizoshita T, Inada K, Tsukamoto T, et al: Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa-with special emphasis on participation in intestinal metaplasia of the human stomach. Gastric Cancer 4:185-191, 2001
30. Hinoi T, Lucas PC, Kuick R, et al: CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia. Gastroenterology 123:1565-1577, 2002
31. Mizoshita T, Inada KI, Tsukamoto T, et al: Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells. J Cancer Res Clin Oncol 130:29-36, 2004
32. Phillips KW, Goldsworthy SM, Bennett LM, et al: Brca1 is expressed independently of hormonal stimulation in the mouse ovary. Lab Invest 76:419-425, 1997