Blinding effectiveness and association of pretreatment expectations with pain improvement in a double-blind randomized controlled trial

Pain

Volumn 99, Issue 1-2, 2002, Pages 91-99

  Turner, Judith A ^a   Jensen, Mark P ^a   Warms, Catherine A ^a   Cardenas, Diana D ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Blinding; Expectations; Nonspecific effects; Pain; Randomized controlled trial

Indexed keywords

AMITRIPTYLINE; BENZATROPINE MESILATE; PLACEBO;

ACCURACY; ADULT; ARTICLE; CHRONIC PAIN; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG EFFECT; DRUG EFFICACY; FATIGUE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NURSE; PAIN ASSESSMENT; PREDICTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SPASTICITY; SPINAL CORD INJURY; SWEATING; TREATMENT OUTCOME; URINE RETENTION; XEROSTOMIA;

ADULT; AMITRIPTYLINE; ANALGESICS, NON-NARCOTIC; ATTITUDE OF HEALTH PERSONNEL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PAIN; PATIENT SATISFACTION; PHYSICIANS; RANDOMIZED CONTROLLED TRIALS; SPECIALTIES, NURSING; SPINAL CORD INJURIES;

EID: 0036710754     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(02)00060-X     Document Type: Article

References (25)

1. Brownell K.D., Stunkard A.J. The double-blind in danger: untoward consequences of informed consent. Am J Psychiatry. 139:1982;1487-1489.
2. Byington R.P., Curb J.D., Mattson M.E. Assessment of double-blindness at the conclusion of the beta-blocker heart attack trial. J Am Med Assoc. 253:1985;1733-1736.
3. Bystritsky A., Waikar S.V. Inert placebo versus active medication. Patient blindability in clinical pharmacological trials. J Nerv Ment Dis. 182:1994;485-487.
4. Cardenas D.D., Warms C.A., Turner J.A., Marshall H.M., Brooke M.M., Loeser J.D. Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial. Pain. 96:2002;365-373.
5. Carroll K.M., Rounsaville B.J., Nich C. Blind man's bluff: effectiveness and significance of psychotherapy and pharmacotherapy blinding procedures in a clinical trial. J Consult Clin Psychol. 62:1994;276-280.
6. Finnerup N.B., Yezierski R.P., Sang C.N., Burchiel K.J., Jensen T.S. Treatment of spinal cord injury pain. Pain Clin Updates. 9:2001;1-6.
7. Galer B.S., Schwartz L., Turner J.A. Do patient and physician expectations predict response to pain-relieving procedures? Clin J Pain. 13:1997;348-351.
8. Gracely R.H., Dubner R., Deeter W.R., Wolskee P.J. Clinicians' expectations influence placebo analgesia. Lancet. 1:1985;43.
9. Hughes J.R., Krahn D. Blindness and the validity of the double-blind procedure. J Clin Psychopharmacol. 5:1985;138-142.
10. Kalauokalani D., Cherkin D.C., Sherman K.J., Koepsell T.D., Deyo R.A. Lessons from a trial of acupuncture and massage for low back pain. Spine. 26:2001;1418-1424.
11. Luparello T., Leist N., Lourie C.H., Sweet P. The interaction of psychologic stimuli and pharmacologic agents on airway reactivity in asthmatic subjects. Psychosom Med. 32:1970;509-513.
12. Macdonald A., Peden N.R., Hayton R., Mallinson C.N., Roberts D., Wormsley K.G. Symptom relief and the placebo effect in the trial of an anti-peptic drug. Gut. 21:1980;323-326.
13. Margraf J., Ehlers A., Roth W.T., Clark D.B., Sheikh J., Agras W.S., Taylor C.B. How 'blind' are double-blind studies? J Consult Clin Psychol. 59:1991;184-187.
14. Marini J.L., Sheard M.H., Bridges C.I., Wagner E. An evaluation of the double-blind design in a study comparing lithium carbonate with placebo. Acta Psychiatr Scand. 33:1976;343-354.
15. McQuay H., Carroll D., Moore A. Variation in the placebo effect in randomised controlled trials of analgesics: all is as blind as it seems. Pain. 64:1995;331-335.
16. McQuay H.J., Tramer M., Nye B.A., Carroll D., Wiffen P.J., Moore R.A. A systematic review of antidepressants in neuropathic pain. Pain. 68:1996;217-227.
17. Moscucci M., Byrne L., Weintraub M., Cox C. Blinding, unblinding, and the placebo effect: An analysis of patients' guesses of treatment assignment in a double-blind clinical trial. Clin Pharmacol Ther. 41:1987;259-265.
18. Onghena P., Van Houdenhove B. Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies. Pain. 49:1992;205-219.
19. Rabkin J.G., Markowitz J.S., Stewart J., McGrath P., Harrison W., Quitkin F.M., Klein D.F. How blind is blind? Assessment of patient and doctor medication guesses in a placebo-controlled trial of imipramine and phenelzine. Psychiatry Res. 19:1986;75-86.
20. Radloff L. The CES scale: A self-report depression scale for research in the general population. Appl Psychol Meas. 1:1977;385-401.
21. Safren S.A., Heimberg R.G., Juster H.R. Clients' expectancies and their relationship to pretreatment symptomatology and outcome of cognitive-behavioral group treatment for social phobia. J Consult Clin Psychol. 65:1997;694-698.
22. Shapiro A.P., Myers T., Reiser M.F., Ferris E.B. Comparison of blood pressure response to Verloid and to the doctor. Psychosom Med. 16:1954;478-488.
23. Turner J.A. Nonspecific treatment effects. Loeser J.D., Bonica's management of pain. 2001;1649-1656 Lippincott Williams and Wilkins, Baltimore, MD.
24. Turner J.A., Deyo R.A., Loeser J.D., Von Korff M., Fordyce W.E. The importance of placebo effects in pain treatment and research. J Am Med Assoc. 271:1994;1609-1614.
25. White K., Kando J., Park T., Waternaux C., Brown W.A. Side effects and the blindability' of clinical drug trials. Am J Psychiatry. 149:1992;1730-1731.