A rare case of adulthood-onset growth hormone deficiency presenting as sporadic, symptomatic hypoglycemia

Journal of Endocrinological Investigation

Volumn 27, Issue 11, 2004, Pages 1060-1064

  Pia, A ^a   Piovesan, A ^a   Tassone, F ^a   Razzore, P ^a   Visconti, G ^b   Magro, G ^a   Cesario, F ^a   Terzolo, M ^c   Borretta, G ^a  

^a Division of Endocrinology and Metabolism   (Italy)

^b Department of Laboratory Medicine ^*  (Italy)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

Adult onset GHD; Head trauma; Hypoglycemia; rhGH therapy

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN C;

ARTICLE; CASE REPORT; GLUCOSE BLOOD LEVEL; HEAD INJURY; HOMEOSTASIS; HUMAN; HYPOGLYCEMIA; HYPOPITUITARISM; MALE; MENTAL STRESS; METABOLISM; MIDDLE AGED; ONSET AGE; RECURRENT DISEASE;

AGE OF ONSET; BLOOD GLUCOSE; CRANIOCEREBRAL TRAUMA; GROWTH HORMONE; HOMEOSTASIS; HUMANS; HYPOGLYCEMIA; HYPOPITUITARISM; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; RECURRENCE; STRESS, PSYCHOLOGICAL;

EID: 15744372065     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/BF03345310     Document Type: Article

References (27)

1. De Boer H, Blok GJ, Van der Veen EA. Clinical aspects of growth hormone deficiency in adults. Endocr Rev 1995, 16: 63-86.
2. McCallum RW, Petrie JR, Dominiczak AF, Connell JM. Growth hormone deficiency and vascular risk. Clin Endocrinol (Oxf) 2002, 57: 11-24.
3. Virally ML, Guillausseau PJ. Hypoglycemia in adults. Diabetes Metab 1999, 25: 477-90.
4. Merimee TJ, Felig P, Marliss E, Fineberg SE, Cahill GC. Glucose and lipid homeostasis in the absence of human growth hormone. J Clin Invest 1971, 50: 574-82.
5. Cuneo RC, Saloman F, McGauley GA, SonKsen PH. The growth hormone deficiency syndrome in adults. Clin Endocrinol (Oxf) 1992, 37: 387-97.
6. Hew FL, Koschmann M, Christopher M, et al. Insulin resistance in growth hormone-deficient adults: defects in glucose utilization and glycogen synthase activity. J Clin Endocrinol Metab 1996, 81: 555-64.
7. Procopio M, Magro G, Cesario F, et al. The oral glucose tolerance test reveals a high frequency of both impaired glucose tolerance and undiagnosed type 2 diabetes mellitus in primary hyperparathyroidism. Diabet Med 2002, 19: 958-61.
8. Christ ER, Carrol PV, Sonksen PH. Adult growth hormone deficiency. In: Wass JAH, Shalet SM eds. Oxford Textbook of Endocrinology and Diabetes. New York: Oxford University Press. 2002, 151-60.
9. Zung A, Andrews-Murray G, Winqvist O, Chalew SA. Growth hormone deficiency in autoimmune polyglandular syndrome. J Pediatr Endocrinol Metab 1997, 10: 69-72.
10. Eichler I, Frisch H, Eichler HG, Soukop W. Isolated growth hormone deficiency after severe head trauma. J Endocrinol Invest 1988, 11: 409-11.
11. Benvenga S, Campenni A, Ruggeri RM, Trimarchi F. Hypopituitarism secondary to head trauma. J Clin Endocrinol Metab 2000, 85: 1353-61.
12. Aimaretti G, Corneli G, Razzore P, et al. Comparison between insulin-induced hypoglycemia and growth hormone (GH)-releasing hormone + arginine as provocative tests for the diagnosis of GH deficiency in adults. J Clin Endocrinol Metab 1998, 83:1615-8.
13. Ron D, Powers AC, Pandian MR, Godine JE, Axelrod L. Increased insulin-like growth factor II production and consequent suppression of growth hormone secretion: a dual mechanism for tumor-induced hypoglycemia. J Clin Endocrinol Metab 1989, 68: 701-6.
14. FuKui M, Nakamura S, Sato H, Matsumoto T, Nakamura N, Kondo M. Severe and recurrent fasting hypoglycemia due to growth hormone deficiency? Arch Intern Med 1999, 159: 1954-6.
15. Cryer PE, Polonsky KS. Glucose homeostasis and hypoglycemia. In: Wilson JD, Foster DW eds. Williams Textbook of Endocrinology. Philadelphia: W.B. Sauders. 1998, 939-71.
16. Moller N, Jorgensen JO, Abildgard N, Orskov L, Schmitz O, Christiansen JS. Effects of growth hormone on glucose metabolism. Horm Res 1991, 36: 32-5.
17. Bolli GB, Fanelli CG. Physiology of glucose counterregulation to hypoglycemia. Endocrinol Metab Clin North Am 1999, 28: 467-93.
18. Johansson JO, Fowelin J, Landin K, Lager I, Bengtsson BA. Growth hormone-deficient adults are insulin-resistant. Metabolism 1995, 44: 1126-9.
19. Jorgensen JOL, Norrelund H, Coceicao F, Moller N, Christiansen S. Somatropin and glucose homeostasis. Considerations for Patient Management. Treat Endocrinol 2002, 1: 229-34.
20. Barreto-Filho JA, Alcantara MR, Salvatori R, et al. Familial isolated growth hormone deficiency is associated with increased systolic blood pressure, central obesity, and dyslipidemia. J Clin Endocrinol Metab 2002, 87: 2018-23.
21. Christ ER, Simpson HL, Breen L, Sonksen PH, Russell-Jones DL, Kohner EM. The effect of growth hormone (GH) replacement therapy in adult patients with type 1 diabetes mellitus and GH deficiency. Clin Endocrinol (Oxf) 2003, 58: 309-15.
22. Salomon F, Cuneo RC, Umpleby AM, Sonksen PH. Glucose and fat metabolism in adults with growth hormone deficiency. Clin Endocrinol(Oxf) 1994, 41: 315-22.
23. Rossetti L, Lee YT, Riniz J, Aldridge SC, Shamoon H, Boden G. Quantitation of glycolysis and skeletal muscle glycogen synthesis in humans. Am J Physiol 1993, 265: E761-E769.
24. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999, 22: 1462-70.
25. Jorgensen JO, Norrelund H, Vahl N, Juul A, Skakkebaek NE, Christiansen JS. Continuation of growth hormone therapy versus placebo in transition-phase patients with growth hormone deficiency: impact on body composition, insulin sensitivity, and thyroid function. J Pediatr Endocrinol Metab 2002, 15: 1355-60.
26. Eden Engstrom B, Burman P, Holdstock C, Karlsson FA. Effects of growth hormone (GH) on ghrelin, leptin, and adiponectin in GH-deficient patients. J Clin Endocrinol Metab 2003, 88: 5193-98.
27. Hartman ML, Crowe BJ, Biller BM, Ho KK, Clemmons DR, Chipman JJ. Which patients do not require a GH stimulation test for the diagnosis of adult GH deficiency? J Clin Endocrinol Metab 2002, 87: 477-85.