Comparison between insulin-induced hypoglycemia and growth hormone (GH)- releasing hormone + arginine as provocative tests for the diagnosis of GH deficiency in adults

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 5, 1998, Pages 1615-1618

  Aimaretti, G ^a   Corneli, G ^a   Razzore, P ^a   Bellone, S ^a   Baffoni, C ^a   Arvat, E ^a   Camanni, F ^a   Ghigo, E ^a,b  

^a UNIVERSITY OF TURIN   (Italy)

^b MOLINETTE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CORTISONE ACETATE; DESMOPRESSIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; INSULIN; NEUTRAL INSULIN; SERMORELIN; SEX HORMONE; SOMATOMEDIN C; THYROID HORMONE;

ADULT; ARTICLE; CLINICAL ARTICLE; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DRUG MIXTURE; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HUMAN; HYPOGLYCEMIA; HYPOPITUITARISM; INTERMETHOD COMPARISON; INTRAVENOUS DRUG ADMINISTRATION; MALE; ONSET AGE; PRIORITY JOURNAL; PROVOCATION TEST; REPRODUCIBILITY;

ADULT; ARGININE; FEMALE; GROWTH HORMONE-RELEASING HORMONE; HUMAN GROWTH HORMONE; HUMANS; HYPOGLYCEMIA; HYPOPITUITARISM; INSULIN; INSULIN-LIKE GROWTH FACTOR I; MALE;

EID: 0031753015     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.5.1615     Document Type: Article

References (28)

1. De Boer H, Blok G, van Der Veen EA. 1995 Clinical aspects of growth hormone deficiency in adults. Endocr Rev. 16:63-86.
2. Jorgensen JOL, Theusen L, Ingemann-Hansen T, et al. 1989 Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet. i:1221-1225.
3. Salomon F, Cuneo RC, Hesp RC, Sonksen PH. 1989 The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency N Engl J Med. 321:1979-1983.
4. Cuneo RC, Salomon F, Mark Wiles C, Hesp RC, Sonksen PH. 1991 Growth hormone treatment in growth hormone deficient adults. II. Effects on exercise performance. Am J Physiol. 70:695-700.
5. Amato G, Carella C, Fazio S, et al. 1993 1993 Body composition, bone metabolism and heart structure and function in growth hormone (GH) deficient adults before and after GH replacement therapy at low doses. J Clin Endocrinol Metab. 77:1671-1676.
6. Merola B, Cittadini A, Colao A, et al. 1993 Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency. J Clin Endocrinol Metab. 77:1658-1663.
7. Cittadini A, Cuocolo A, Merola B, et al. 1994 Impaired cardiac performance in GH-deficient adults and its improvement after GH replacement. Am J Physiol. 267:E219-E225.
8. Rosen T, Bengtsson BA. 1990 Premature mortality due to cardiovascular disease in hypopituitarism. Lancet. 336:285-288.
9. Hoffman DM, O Sullivan AJ, Baxter RC, Ho KY. 1994 Diagnosis of growth hormone deficiency in adults. Lancet. i:1064-1068.
10. Ghigo E, Aimaretti G, Gianotti L, Bellone J, Arvat E, Camanni F. 1996 New approach to the diagnosis of growth hormone deficiency in adults. Eur J Endocrinol. 134:352-356.
11. Growth Hormone Research Society (GRS). 1998 Consensus guidelines for diagnosis and treatment of adults with GH deficiency. Porth Stephens workshops April 1997. J Clin Endocrinol Metab. 83:379-381.
12. Thomer MO, Bengtsson BA, Ho KKY, et al. 1995 Diagnosis of growth hormone deficiency in adults. J Clin Endocrinol Metab. 80:3097-3098.
13. Svensson J, Johannsson G, Bengtsson BA. 1997 Insulin-like growth factor-I in growth hormone-deficient adults: relationship to population-based normal value, body composition and insulin tolerance test. Clin Endocrinol (Oxf). 46:579-586.
14. Reutens AT, Hoffmann DM, Leung K, Ho KKY. 1995 Evaluation and application of a highly sensitive assay for serum growth hormone (GH) in the study of adult GH deficiency. J Clin Endocrinol Metab. 80:480-485.
15. Jones SL, Trainer PJ, Perry L, Wass JAH, Besser GM, Grossman A. 1994 An audit of the insulin tolerance test in adult subjects in an acute investigation unit over one year. Clin Endocrinol (Oxf). 41:123-128.
16. Hoeck HC, Vestergaard P, Jakobsen PE, Laurberg P. 1995 Test of growth hormone secretion in adults: poor reproducibility of the insulin tolerance test. Eur J Endocrinol. 133:305-312.
17. Vestergaard P, Hoeck HC, Jakobsen E, Laurbarg P. 1997 Reproducibility of growth hormone and Cortisol responses to the insulin tolerance test and the short ACTH test in normal adults. Horm Metab Res. 29:106-110.
18. Rahim A, Toogood, Shalet SM. 1996 The assessment of growth hormone in normal young adult using a variety of provocative agents. Clin Endocrinol (Oxf). 45:557-562.
19. Longobardi S, Merola B, Pivonello R, et al. 1996 Re-evaluation of growth hormone (GH) secretion in 69 adults diagnosed as GH-deficient patients during childhood. J Clin Endocrinol Metab. 81:1244-1247.
20. Andersen M, Hansen TB, Stoving RK. 1996 The pyridostigmine-growth-hormone-releasing-hormone test in adults. The reference interval and a comparison with the insulin tolerance test. Endocrinol Metab. 3:197-206.
21. Baum HBA, Biller BMK, Katznelson L, et al. 1996 Assessment of growth hormone (GH) secretion in men with adult-onset GH deficiency with that in normal men - a clinical research study. J Clin Endocrinol Metab. 81:84-92.
22. Ghigo E, Bellone J, Aimaretti G, et al. 1996 Reliability of provocative tests to assess growth hormone secretory status. Study in 472 normally growing children. J Clin Endocrinol Metab. 81:3323-3327.
23. Valetto MR, Bellone J, Baffoni C, et al. 1996 Reproducibility of the growth hormone response to stimulation with growth hormone-releasing hormone plus arginine during lifespan. Eur J Endocrinol. 135:568-572.
24. Ghigo E. 1992 Neurotransmitter control of growth hormone secretion. In: De la Cruz LF, ed. Regulation of growth hormone and somatic growth. Amsterdam: Elsevier Science Publishers; 103-136.
25. Ghigo E, Goffi S, Nicolosi M, et al. 1990 Pyridostigmine partially restores the GH responsiveness to GHRH in normal aging. Acta Endocrinol (Copenh). 123:169-174.
26. Ghigo E, Goffi S, Nicolosi M, et al. 1990 Growth hormone (GH) responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in man. J Clin Endocrinol Metab. 71:874-876.
27. Ghigo E, Nicolosi M, Arvat E, et al. 1994 Growth hormone secretion in Alzheimer's disease: studies with growth hormone releasing hormone alone and combined with pyridostigmine or arginine. Dementia. 4:315-320.
28. Underwood LE, Van Wyk JJ. Normal and aberrant growth. In: Wilson JD, Foster UW, eds. Williams textbook of endocrinology. 8th ed. Philadelphia: Saunders Co.; 1992.